ENSMUSG00000047804


Mus musculus

Features
Gene ID: ENSMUSG00000047804
  
Biological name :Akap10
  
Synonyms : Akap10 / A-kinase anchor protein 10, mitochondrial / O88845
  
Possible biological names infered from orthology : A-kinase anchoring protein 10 / O43572
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B2
Gene start: 61871307
Gene end: 61930252
  
Corresponding Affymetrix probe sets: 10386824 (MoGene1.0st)   1421121_at (Mouse Genome 430 2.0 Array)   1428482_at (Mouse Genome 430 2.0 Array)   1441829_s_at (Mouse Genome 430 2.0 Array)   1441830_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000054418
Ensembl peptide - ENSMUSP00000099710
Ensembl peptide - ENSMUSP00000104350
NCBI entrez gene - 56697     See in Manteia.
MGI - MGI:1890218
RefSeq - NM_019921
RefSeq - XM_006533814
RefSeq Peptide - NP_064305
swissprot - O88845
Ensembl - ENSMUSG00000047804
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 akap10ENSDARG00000059549Danio rerio
 AKAP10ENSGALG00000004679Gallus gallus
 AKAP10ENSG00000108599Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR016137  RGS domain
 IPR024066  RGS, subdomain 1/3
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008104 protein localization ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0051018 protein kinase A binding ISS


Pathways (from Reactome)
Pathway description
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Smg9tm1b(EUCOMM)Wtsi/Smg9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smg9tm1b(EUCOMM)Wtsi/Wtsi

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
Show

Allelic Composition: EdaTa-6J/Y,Tg(MMTVtTA)1Mam/0,Tg(tetO-Eda*A1)1Dsch/0
Genetic Background: involves: C57BL/6J

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Smg9tm1b(EUCOMM)Wtsi/Smg9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smg9tm1b(EUCOMM)Wtsi/Wtsi

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: EdaTa-6J/Y,Tg(MMTVtTA)1Mam/0,Tg(tetO-Eda*A1)1Dsch/0
Genetic Background: involves: C57BL/6J

Allelic Composition: Akap10Gt(RRC139)Byg/Akap10+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003928 increased heart rate variability "increased variation of beat-to-beat intervals of the heart, usually indicitive of a healthy heart" [RGD:Rat Genome Database submission]
Show

Allelic Composition: EdaTa-6J/Y,Tg(MMTVtTA)1Mam/0,Tg(tetO-Eda*A1)1Dsch/0
Genetic Background: involves: C57BL/6J

 MP:0004070 abnormal P wave "any anomaly in the P wave which is normally caused by atrial depolarization and corresponds to electrical impulses rather than mechanical atria contractions; irregular or absent P waves may indicate arrhythmia and the shape of the P waves may indicate atrial problems" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: EdaTa-6J/Y,Tg(MMTVtTA)1Mam/0,Tg(tetO-Eda*A1)1Dsch/0
Genetic Background: involves: C57BL/6J

 MP:0004122 sinus arrhythmia "irregular heartbeat related to abnormal function of the sinoatrial node" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: EdaTa-6J/Y,Tg(MMTVtTA)1Mam/0,Tg(tetO-Eda*A1)1Dsch/0
Genetic Background: involves: C57BL/6J

 MP:0004184 abnormal baroreceptor physiology "anomaly in the function of the sensory nerve endings found in the wall of the atria of the heart, vena cava, aortic arch and carotid sinus that are sensitive to changes in blood pressure" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: EdaTa-6J/Y,Tg(MMTVtTA)1Mam/0,Tg(tetO-Eda*A1)1Dsch/0
Genetic Background: involves: C57BL/6J

 MP:0004848 abnormal liver size "anomaly in the average size of the liver " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smg9tm1b(EUCOMM)Wtsi/Smg9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smg9tm1b(EUCOMM)Wtsi/Wtsi

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: EdaTa-6J/Y,Tg(MMTVtTA)1Mam/0,Tg(tetO-Eda*A1)1Dsch/0
Genetic Background: involves: C57BL/6J

Allelic Composition: Akap10Gt(RRC139)Byg/Akap10+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005382 craniofacial phenotype 
Show

Allelic Composition: Smg9tm1b(EUCOMM)Wtsi/Smg9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smg9tm1b(EUCOMM)Wtsi/Wtsi

 MP:0006142 abnormal sinoatrial node conduction "anomaly in the generation or transfer of electrical impulses that trigger contraction of the atria and ventricles" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: EdaTa-6J/Y,Tg(MMTVtTA)1Mam/0,Tg(tetO-Eda*A1)1Dsch/0
Genetic Background: involves: C57BL/6J

 MP:0010519 atrioventricular block "a partial or complete obstruction of the impulse that originates in the atria or sinoatrial node from reaching or transmitting through the atrioventricular node to the ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: EdaTa-6J/Y,Tg(MMTVtTA)1Mam/0,Tg(tetO-Eda*A1)1Dsch/0
Genetic Background: involves: C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Aff3tm1a(EUCOMM)Wtsi/Aff3+
Genetic Background: C57BL/6N-Aff3tm1a(EUCOMM)Wtsi/Wtsi

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Aff3tm1a(EUCOMM)Wtsi/Aff3+
Genetic Background: C57BL/6N-Aff3tm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005034 P68181 / Prkacb / protein kinase, cAMP dependent, catalytic, beta / P22694* / protein kinase cAMP-activated catalytic subunit beta*  / complex / reaction
 ENSMUSG00000020612 Q9DBC7 / Prkar1a / protein kinase, cAMP dependent regulatory, type I, alpha / P10644* / protein kinase cAMP-dependent type I regulatory subunit alpha*  / complex / reaction
 ENSMUSG00000025855 P12849 / Prkar1b / protein kinase, cAMP dependent regulatory, type I beta / P31321* / protein kinase cAMP-dependent type I regulatory subunit beta*  / complex / reaction
 ENSMUSG00000002997 P31324 / Prkar2b / protein kinase, cAMP dependent regulatory, type II beta / P31323* / protein kinase cAMP-dependent type II regulatory subunit beta*  / complex / reaction
 ENSMUSG00000005469 P05132 / Prkaca / protein kinase, cAMP dependent, catalytic, alpha / P17612* / protein kinase cAMP-activated catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000032601 Prkar2a / protein kinase, cAMP dependent regulatory, type II alpha / P13861* / protein kinase cAMP-dependent type II regulatory subunit alpha*  / reaction / complex






 

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