ENSGALG00000004237


Gallus gallus

Features
Gene ID: ENSGALG00000004237
  
Biological name :PRKAR1A
  
Synonyms : cAMP-dependent protein kinase type I-alpha regulatory subunit / PRKAR1A / Q5ZM91
  
Possible biological names infered from orthology : P10644 / protein kinase, cAMP dependent regulatory, type I, alpha / protein kinase cAMP-dependent type I regulatory subunit alpha / Q9DBC7
  
Species: Gallus gallus
  
Chr. number: 18
Strand: 1
Band:
Gene start: 7927304
Gene end: 7943491
  
Corresponding Affymetrix probe sets: GgaAffx.11596.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000033915
NCBI entrez gene - 417438     See in Manteia.
RefSeq - XM_015279894
RefSeq - NM_001007845
RefSeq - XM_015279892
RefSeq - XM_015279893
RefSeq Peptide - NP_001007846
swissprot - Q5ZM91
Ensembl - ENSGALG00000004237
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkar1abENSDARG00000101755Danio rerio
 P10644ENSG00000108946Homo sapiens
 Q9DBC7ENSMUSG00000020612Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRKAR1B / protein kinase cAMP-dependent type I regulatory subunit beta / P12849* / P31321* / protein kinase, cAMP dependent regulatory, type I beta*ENSGALG0000000367586
PRKAR2B / protein kinase cAMP-dependent type II regulatory subunit beta / P31323* / P31324* / protein kinase, cAMP dependent regulatory, type II beta*ENSGALG0000000806037
PRKAR2A / protein kinase cAMP-dependent type II regulatory subunit alpha / P13861* / protein kinase, cAMP dependent regulatory, type II alpha*ENSGALG0000000702335


Protein motifs (from Interpro)
Interpro ID Name
 IPR000595  Cyclic nucleotide-binding domain
 IPR003117  cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
 IPR012198  cAMP-dependent protein kinase regulatory subunit
 IPR014710  RmlC-like jelly roll fold
 IPR018488  Cyclic nucleotide-binding, conserved site
 IPR018490  Cyclic nucleotide-binding-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001707 mesoderm formation IEA
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0045214 sarcomere organization IEA
 biological_processGO:0046007 negative regulation of activated T cell proliferation IEA
 biological_processGO:0060038 cardiac muscle cell proliferation IEA
 biological_processGO:2000480 negative regulation of cAMP-dependent protein kinase activity IEA
 cellular_componentGO:0001772 immunological synapse IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005930 axoneme IEA
 cellular_componentGO:0005952 cAMP-dependent protein kinase complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031588 nucleotide-activated protein kinase complex IEA
 cellular_componentGO:0031594 neuromuscular junction IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0044853 plasma membrane raft IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004862 cAMP-dependent protein kinase inhibitor activity IEA
 molecular_functionGO:0008603 cAMP-dependent protein kinase regulator activity IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030552 cAMP binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0034236 protein kinase A catalytic subunit binding IEA


Pathways (from Reactome)
Pathway description
PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Vasopressin regulates renal water homeostasis via Aquaporins
Hedgehog off state
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003675 PRKAR1B / protein kinase cAMP-dependent type I regulatory subunit beta / P12849* / P31321* / protein kinase, cAMP dependent regulatory, type I beta*  / complex
 ENSGALG00000007023 PRKAR2A / protein kinase cAMP-dependent type II regulatory subunit alpha / P13861* / protein kinase, cAMP dependent regulatory, type II alpha*  / complex
 ENSGALG00000004237 Q5ZM91 / PRKAR1A / cAMP-dependent protein kinase type I-alpha regulatory subunit / Q9DBC7* / P10644* / protein kinase, cAMP dependent regulatory, type I, alpha* / protein kinase cAMP-depen...  / complex
 ENSGALG00000005575 AKAP1 / A-kinase anchoring protein 1 / O08715* / Q92667* / A-kinase anchor protein 1, mitochondrial *  / reaction / complex






 

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