ENSMUSG00000023411


Mus musculus

Features
Gene ID: ENSMUSG00000023411
  
Biological name :Nfatc4
  
Synonyms : Nfatc4 / Nuclear factor of activated T-cells, cytoplasmic 4 / Q8K120
  
Possible biological names infered from orthology : nuclear factor of activated T cells 4 / Q14934
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: C3
Gene start: 55823144
Gene end: 55833943
  
Corresponding Affymetrix probe sets: 10415396 (MoGene1.0st)   1423379_at (Mouse Genome 430 2.0 Array)   1423380_s_at (Mouse Genome 430 2.0 Array)   1432821_at (Mouse Genome 430 2.0 Array)   1454369_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024179
Ensembl peptide - ENSMUSP00000132763
Ensembl peptide - ENSMUSP00000154682
Ensembl peptide - ENSMUSP00000154776
Ensembl peptide - ENSMUSP00000154813
NCBI entrez gene - 73181     See in Manteia.
MGI - MGI:1920431
RefSeq - NM_001168346
RefSeq - NM_023699
RefSeq Peptide - NP_001161818
RefSeq Peptide - NP_076188
swissprot - Q8K120
Ensembl - ENSMUSG00000023411
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfatc4ENSDARG00000054162Danio rerio
 NFATC4ENSG00000100968Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nfatc3 / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 / Q12968* / nuclear factor of activated T cells 3*ENSMUSG0000003190242
Nfatc1 / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 / O95644* / nuclear factor of activated T cells 1*ENSMUSG0000003301635
Nfatc2 / Q60591 / nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 / Q13469* / nuclear factor of activated T cells 2*ENSMUSG0000002754433
Nfat5 / Q9WV30 / nuclear factor of activated T cells 5 / O94916*ENSMUSG0000000384719


Protein motifs (from Interpro)
Interpro ID Name
 IPR002909  IPT domain
 IPR008366  Nuclear factor of activated T cells (NFAT)
 IPR008967  p53-like transcription factor, DNA-binding
 IPR011539  Rel homology domain (RHD), DNA-binding domain
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR032397  Rel homology dimerisation domain
 IPR037059  Rel homology domain (RHD), DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007507 heart development IGI
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IDA
 biological_processGO:0032091 negative regulation of protein binding IDA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IMP
 biological_processGO:0033173 calcineurin-NFAT signaling cascade IGI
 biological_processGO:0034644 cellular response to UV IGI
 biological_processGO:0035562 negative regulation of chromatin binding IDA
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0045333 cellular respiration IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048167 regulation of synaptic plasticity IEA
 biological_processGO:0050774 negative regulation of dendrite morphogenesis IMP
 biological_processGO:0051145 smooth muscle cell differentiation IGI
 biological_processGO:0055001 muscle cell development IGI
 biological_processGO:0071285 cellular response to lithium ion IDA
 biological_processGO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II ISO
 biological_processGO:1904637 cellular response to ionomycin IEA
 biological_processGO:2000297 negative regulation of synapse maturation IMP
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016607 nuclear speck ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IDA
 molecular_functionGO:0042975 peroxisome proliferator activated receptor binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mitfmi-bws/Mitfmi-bws
Genetic Background: BKS.Cg-m+/+Leprdb

Allelic Composition: Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Jmk/Nfatc4tm1Jmk
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Jmk/Nfatc4tm1Jmk
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Mitfmi-bws/Mitfmi-bws
Genetic Background: BKS.Cg-m+/+Leprdb

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
Show

Allelic Composition: Mitfmi-bws/Mitfmi-bws
Genetic Background: BKS.Cg-m+/+Leprdb

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
Show

Allelic Composition: Mitfmi-bws/Mitfmi-bws
Genetic Background: BKS.Cg-m+/+Leprdb

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0000458 abnormal mandible morphology "malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
Show

Allelic Composition: Mitfmi-bws/Mitfmi-bws
Genetic Background: BKS.Cg-m+/+Leprdb

Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0001065 abnormal trigeminal nerve morphology "malformed chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:33038]
Show

Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
Show

Allelic Composition: Mitfmi-bws/Mitfmi-bws
Genetic Background: BKS.Cg-m+/+Leprdb

Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfatc4tm1Jmk/Nfatc4tm1Jmk,Tg(Myh6-Ppp3ca)37Eno/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Jmk/Nfatc4tm1Jmk
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mitfmi-bws/Mitfmi-bws
Genetic Background: BKS.Cg-m+/+Leprdb

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Btkxid/?,Tg(IGH-Btk)1Witt/Tg(IGH-Btk)1Witt
Genetic Background: involves: BALB/c * C3H * C57BL/6 * CBA/N

Allelic Composition: Nfatc4tm1Jmk/Nfatc4tm1Jmk,Tg(Myh6-Ppp3ca)37Eno/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Mitfmi-bws/Mitfmi-bws
Genetic Background: BKS.Cg-m+/+Leprdb

 MP:0002557 abnormal social/conspecific interaction "deviation of the normal behavior of mice towards each other" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mitfmi-bws/Mitfmi-bws
Genetic Background: BKS.Cg-m+/+Leprdb

Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0002926 aganglionic megacolon "extreme dilation of the colon due to defects in innervation from the ganglia, or absence of the ganglia of the myenteric plexus" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mitfmi-bws/Mitfmi-bws
Genetic Background: BKS.Cg-m+/+Leprdb

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Mitfmi-bws/Mitfmi-bws
Genetic Background: BKS.Cg-m+/+Leprdb

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Jmk/Nfatc4tm1Jmk
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0004056 abnormal myocardial compact layer morphology "malformation of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Jmk/Nfatc4tm1Jmk
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0004067 abnormal ventricular trabeculae morphology "aberrant structure of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Jmk/Nfatc4tm1Jmk
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0004144 hypotonia "decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0004469 abnormal zygomatic arch morphology "any structural anomaly of the bony arch in vertebrates that extends along the side or front of the skull beneath the eye socket and is formed by the temporal process of the zygomatic bone and the zygomatic process of the temporal bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
Show

Allelic Composition: Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Jmk/Nfatc4tm1Jmk
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfatc4tm1Jmk/Nfatc4tm1Jmk,Tg(Myh6-Ppp3ca)37Eno/?
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB

Allelic Composition: Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Jmk/Nfatc4tm1Jmk
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Jmk/Nfatc4tm1Jmk
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Jmk/Nfatc4tm1Jmk
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Jmk/Nfatc4tm1Jmk
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0006261 annular pancreas "an abnormal ring or collar of pancreatic tissue that encircles the duodenum" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:69854]
Show

Allelic Composition: Mitfmi-bws/Mitfmi-bws
Genetic Background: BKS.Cg-m+/+Leprdb

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mitfmi-bws/Mitfmi-bws
Genetic Background: BKS.Cg-m+/+Leprdb

 MP:0009677 abnormal spinal cord dorsal column morphology "any structural anomaly of the wedge-shaped fiber bundle of white matter in the dorsomedial side of the spinal cord that is made up of the fasciculus gracilis and fasciculus cuneatus; it is part of the ascending posterior column-medial lemniscus pathway that is important for well-localized fine touch and conscious proprioception" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN-10:0940780577 "Goldberg, S, Clinical Neuroanatomy Made Ridiculously Simple, 3rd edition"]
Show

Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Nfatc2tm1Glm/Nfatc2tm1Glm,Nfatc4tm1Grc/Nfatc4tm1Grc
Genetic Background: involves: 129S2/SvPas

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
Show

Allelic Composition: Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Jmk/Nfatc4tm1Jmk
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Jmk/Nfatc4tm1Jmk
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Nfatc3tm1Glm/Nfatc3tm1Glm,Nfatc4tm1Jmk/Nfatc4tm1Jmk,Tg(Myh6-NFATC4)#Eno/?
Genetic Background: involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Mitfmi-bws/Mitfmi-bws
Genetic Background: BKS.Cg-m+/+Leprdb

 MP:0012253 abnormal intersomitic vessel morphology "any structural anomaly of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites" [MGI:anna]
Show

Allelic Composition: Mitfmi-bws/Mitfmi-bws
Genetic Background: BKS.Cg-m+/+Leprdb

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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