ENSG00000088992


Homo sapiens

Features
Gene ID: ENSG00000088992
  
Biological name :TESC
  
Synonyms : Q96BS2 / TESC / tescalcin
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q24.22
Gene start: 117038923
Gene end: 117099479
  
Corresponding Affymetrix probe sets: 218872_at (Human Genome U133 Plus 2.0 Array)   240553_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000334785
Ensembl peptide - ENSP00000432716
Ensembl peptide - ENSP00000445689
Ensembl peptide - ENSP00000450386
Ensembl peptide - ENSP00000432608
NCBI entrez gene - 54997     See in Manteia.
OMIM - 611585
RefSeq - XM_017019533
RefSeq - NM_001168325
RefSeq - NM_017899
RefSeq - XM_011538503
RefSeq - XM_017019532
RefSeq Peptide - NP_060369
RefSeq Peptide - NP_001161797
swissprot - H0YIX4
swissprot - Q96BS2
swissprot - E9PQ58
Ensembl - ENSG00000088992
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tescaENSDARG00000028346Danio rerio
 tescbENSDARG00000030839Danio rerio
 TESCENSGALG00000008206Gallus gallus
 TescENSMUSG00000029359Mus musculus
 TesclENSMUSG00000055826Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CHP1 / Q99653 / calcineurin like EF-hand protein 1ENSG0000018744630
P63098 / PPP3R1 / protein phosphatase 3 regulatory subunit B, alphaENSG0000022182325
PPP3R2 / Q96LZ3 / protein phosphatase 3 regulatory subunit B, betaENSG0000018838623
CHP2 / O43745 / calcineurin like EF-hand protein 2ENSG0000016686923
AC017083.3ENSG0000027339820


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030854 positive regulation of granulocyte differentiation IDA
 biological_processGO:0032417 positive regulation of sodium:proton antiporter activity IDA
 biological_processGO:0033628 regulation of cell adhesion mediated by integrin IMP
 biological_processGO:0043086 negative regulation of catalytic activity IEA
 biological_processGO:0045654 positive regulation of megakaryocyte differentiation IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0050821 protein stabilization IDA
 biological_processGO:0051604 protein maturation IDA
 biological_processGO:0071300 cellular response to retinoic acid IDA
 biological_processGO:0072659 protein localization to plasma membrane IDA
 cellular_componentGO:0001726 ruffle ISS
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000287 magnesium ion binding ISS
 molecular_functionGO:0004860 protein kinase inhibitor activity IEA
 molecular_functionGO:0005509 calcium ion binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019212 phosphatase inhibitor activity ISS
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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