ENSG00000171552


Homo sapiens

Features
Gene ID: ENSG00000171552
  
Biological name :BCL2L1
  
Synonyms : BCL2L1 / BCL2 like 1 / Q07817
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: q11.21
Gene start: 31664452
Gene end: 31723989
  
Corresponding Affymetrix probe sets: 206665_s_at (Human Genome U133 Plus 2.0 Array)   212312_at (Human Genome U133 Plus 2.0 Array)   215037_s_at (Human Genome U133 Plus 2.0 Array)   231228_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000406203
Ensembl peptide - ENSP00000401173
Ensembl peptide - ENSP00000411252
Ensembl peptide - ENSP00000302564
Ensembl peptide - ENSP00000365223
Ensembl peptide - ENSP00000365230
Ensembl peptide - ENSP00000389688
Ensembl peptide - ENSP00000390760
Ensembl peptide - ENSP00000395545
NCBI entrez gene - 598     See in Manteia.
OMIM - 600039
RefSeq - XM_017027993
RefSeq - NM_001191
RefSeq - NM_001317919
RefSeq - NM_001317920
RefSeq - NM_001317921
RefSeq - NM_001322239
RefSeq - NM_001322240
RefSeq - NM_001322242
RefSeq - NM_138578
RefSeq - XM_011528964
RefSeq Peptide - NP_001304848
RefSeq Peptide - NP_001304849
RefSeq Peptide - NP_001304850
RefSeq Peptide - NP_001309168
RefSeq Peptide - NP_001309169
RefSeq Peptide - NP_001309171
RefSeq Peptide - NP_612815
RefSeq Peptide - NP_001182
swissprot - Q5QP56
swissprot - Q5QP59
swissprot - Q5TE63
swissprot - Q5TE64
swissprot - Q9H1R6
swissprot - A0A0S2Z3C5
swissprot - Q07817
Ensembl - ENSG00000171552
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bcl2l1ENSDARG00000008434Danio rerio
 BCL2L1ENSGALG00000006211Gallus gallus
 Bcl2l1ENSMUSG00000007659Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BCL2 / P10415 / BCL2, apoptosis regulatorENSG0000017179140
BCL2L2 / Q92843 / BCL2 like 2ENSG0000012947339
BAK1 / Q16611 / BCL2 antagonist/killer 1ENSG0000003011015


Protein motifs (from Interpro)
Interpro ID Name
 IPR002475  Bcl2-like
 IPR003093  Apoptosis regulator, Bcl-2 protein, BH4
 IPR004725  Apoptosis regulator, Bcl-2/ BclX
 IPR013279  Apoptosis regulator, Bcl-X
 IPR020717  Apoptosis regulator, Bcl-2, BH1 motif, conserved site
 IPR020726  Apoptosis regulator, Bcl-2, BH2 motif, conserved site
 IPR020728  Apoptosis regulator, Bcl-2, BH3 motif, conserved site
 IPR020731  Apoptosis regulator, Bcl-2, BH4 motif, conserved site
 IPR026298  Blc2 family
 IPR036834  Blc2-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001541 ovarian follicle development IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001836 release of cytochrome c from mitochondria IDA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007093 mitotic cell cycle checkpoint IMP
 biological_processGO:0007281 germ cell development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IEA
 biological_processGO:0008637 apoptotic mitochondrial changes TAS
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0009566 fertilization IEA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0019050 suppression by virus of host apoptotic process IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0032465 regulation of cytokinesis IMP
 biological_processGO:0034097 response to cytokine IDA
 biological_processGO:0040007 growth IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0046898 response to cycloheximide IEA
 biological_processGO:0046902 regulation of mitochondrial membrane permeability IDA
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:0051881 regulation of mitochondrial membrane potential IDA
 biological_processGO:0060154 cellular process regulating host cell cycle in response to virus IEA
 biological_processGO:0070584 mitochondrion morphogenesis IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IEA
 biological_processGO:0071312 cellular response to alkaloid IEA
 biological_processGO:0071480 cellular response to gamma radiation IEA
 biological_processGO:0071839 apoptotic process in bone marrow IEA
 biological_processGO:0090201 negative regulation of release of cytochrome c from mitochondria IC
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IEA
 biological_processGO:0097284 hepatocyte apoptotic process IEA
 biological_processGO:1900118 negative regulation of execution phase of apoptosis IDA
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
 biological_processGO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IDA
 biological_processGO:1903077 negative regulation of protein localization to plasma membrane IDA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand TAS
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway IDA
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion TAS
 cellular_componentGO:0005741 mitochondrial outer membrane IBA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0097136 Bcl-2 family protein complex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0046982 protein heterodimerization activity IBA
 molecular_functionGO:0051434 BH3 domain binding IPI


Pathways (from Reactome)
Pathway description
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Interleukin-4 and Interleukin-13 signaling
The NLRP1 inflammasome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000091592 NLRP1 / Q9C000 / NLR family pyrin domain containing 1  / complex / reaction






 

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