ENSMUSG00000089682


Mus musculus

Features
Gene ID: ENSMUSG00000089682
  
Biological name :Bcl2l2
  
Synonyms : Bcl2l2 / Bcl-2-like protein 2 / P70345
  
Possible biological names infered from orthology : BCL2 like 2 / Q92843
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: C2
Gene start: 54883377
Gene end: 54888234
  
Corresponding Affymetrix probe sets: 10415111 (MoGene1.0st)   1423572_at (Mouse Genome 430 2.0 Array)   1430453_a_at (Mouse Genome 430 2.0 Array)   1430454_x_at (Mouse Genome 430 2.0 Array)   1451029_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022806
Ensembl peptide - ENSMUSP00000116385
Ensembl peptide - ENSMUSP00000133286
Ensembl peptide - ENSMUSP00000154395
NCBI entrez gene - 12050     See in Manteia.
MGI - MGI:108052
RefSeq - NM_007537
RefSeq - XM_006518457
RefSeq - XM_006518458
RefSeq Peptide - NP_031563
swissprot - G3XA70
swissprot - P70345
Ensembl - ENSMUSG00000089682
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BCL2L2ENSG00000129473Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bcl2l1 / Q64373 / Mus musculus BCL2-like 1 (Bcl2l1), transcript variant 5, mRNA. / Q07817* / BCL2 like 1*ENSMUSG0000000765947
Bcl2 / P10417 / Apoptosis regulator Bcl-2 / P10415* / BCL2, apoptosis regulator*ENSMUSG0000005732941
Bak1 / O08734 / Bcl-2 homologous antagonist/killer / Q16611* / BCL2 antagonist/killer 1*ENSMUSG0000005778920


Protein motifs (from Interpro)
Interpro ID Name
 IPR002475  Bcl2-like
 IPR003093  Apoptosis regulator, Bcl-2 protein, BH4
 IPR013280  Apoptosis regulator, Bcl-W
 IPR020717  Apoptosis regulator, Bcl-2, BH1 motif, conserved site
 IPR020726  Apoptosis regulator, Bcl-2, BH2 motif, conserved site
 IPR020731  Apoptosis regulator, Bcl-2, BH4 motif, conserved site
 IPR026298  Blc2 family
 IPR036834  Blc2-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IBA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0060011 Sertoli cell proliferation IGI
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IDA
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IBA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IDA
 cellular_componentGO:0097136 Bcl-2 family protein complex ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IBA
 molecular_functionGO:0046982 protein heterodimerization activity IBA
 molecular_functionGO:0051400 BH domain binding IEA
 molecular_functionGO:0097718 disordered domain specific binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor,Grid2ho-4J/Grid2ho-4J
Genetic Background: involves: 129S5/SvEvBrd * DBA/2J

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor,Grid2ho-4J/Grid2ho-4J
Genetic Background: involves: 129S5/SvEvBrd * DBA/2J

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor,Grid2ho-4J/Grid2ho-4J
Genetic Background: involves: 129S5/SvEvBrd * DBA/2J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
Show

Allelic Composition: ArTfm/Y
Genetic Background: STOCK EdaTa Atp7aMo-blo/+ +

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Bcl2l2tm1Sco/Bcl2l2tm1Sco
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Egfrtm1.1Dwt/Egfrtm1.1Dwt
Genetic Background: involves: 129S6/SvEvTac

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Egfrtm1.1Dwt/Egfrtm1.1Dwt
Genetic Background: involves: 129S6/SvEvTac

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor,Grid2ho-4J/Grid2ho-4J
Genetic Background: involves: 129S5/SvEvBrd * DBA/2J

 MP:0001750 increased circulating follicle stimulating hormone level "higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [J:35782, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcl2l2tm1Sco/Bcl2l2tm1Sco
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002209 germ cell depletion "reduced numbers of any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: ArTfm/Y
Genetic Background: STOCK EdaTa Atp7aMo-blo/+ +

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002785 absent Leydig cells "lack of the interstitial cells of the seminiferous tubules that secrete testosterone " [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004910 decreased seminal gland weight "reduction in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0004996 abnormal CNS synapse formation "any anomaly in the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor,Grid2ho-4J/Grid2ho-4J
Genetic Background: involves: 129S5/SvEvBrd * DBA/2J

 MP:0004998 decreased CNS synapse formation "a reduction in the frequency of the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor,Grid2ho-4J/Grid2ho-4J
Genetic Background: involves: 129S5/SvEvBrd * DBA/2J

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
Show

Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor,Grid2ho-4J/Grid2ho-4J
Genetic Background: involves: 129S5/SvEvBrd * DBA/2J

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Bcl2l2tm1Sco/Bcl2l2tm1Sco
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0005250 Sertoli cell hypoplasia "decreased number of cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:70212]
Show

Allelic Composition: Bcl2l2tm1Sco/Bcl2l2tm1Sco
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor,Grid2ho-4J/Grid2ho-4J
Genetic Background: involves: 129S5/SvEvBrd * DBA/2J

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2l2tm1Sco/Bcl2l2tm1Sco
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl2tm1Mpin/Bcl2tm1Mpin
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor,Grid2ho-4J/Grid2ho-4J
Genetic Background: involves: 129S5/SvEvBrd * DBA/2J

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
Show

Allelic Composition: Bcl2l2tm1Sco/Bcl2l2tm1Sco
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0020355 abnormal Sertoli cell barrier morphology "any structural anomaly of the physical barrier found between adjacent Sertoli cells within the seminiferous tubules; the sertoli cell barrier consists of several types of cellular junctions including tight junctions, gap junctions and adhesion junctions, and divides the seminiferous tubules into the basal and apical (adluminal) compartments" [PMID:24713828 http://www.ajandrology.com/article.asp?issn=1008-682X;year=2014;volume=16;issue=4;spage=572;epage=580;aulast=Jiang]
Show

Allelic Composition: Bcl2l2Gt(ROSA)41Sor/Bcl2l2Gt(ROSA)41Sor
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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