ENSGALG00000012885


Gallus gallus

Features
Gene ID: ENSGALG00000012885
  
Biological name :BCL2
  
Synonyms : Apoptosis regulator Bcl-2 / BCL2 / Q00709
  
Possible biological names infered from orthology : BCL2, apoptosis regulator / P10415 / P10417
  
Species: Gallus gallus
  
Chr. number: 2
Strand: 1
Band:
Gene start: 68102902
Gene end: 68190463
  
Corresponding Affymetrix probe sets: Gga.4394.1.S1_at (Chicken Array)   Gga.4394.1.S2_at (Chicken Array)   Gga.4394.1.S2_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000061728
Ensembl peptide - ENSGALP00000020984
NCBI entrez gene - 396282     See in Manteia.
RefSeq - NM_205339
RefSeq Peptide - NP_990670
swissprot - Q00709
swissprot - A0A1L1RSE7
Ensembl - ENSGALG00000012885
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bcl2aENSDARG00000094704Danio rerio
 bcl2bENSDARG00000089109Danio rerio
 BCL2ENSG00000171791Homo sapiens
 Bcl2ENSMUSG00000057329Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q07816 / BCL2L1 / Bcl-2-like protein 1 / Q64373* / Q07817* / BCL2 like 1* / Mus musculus BCL2-like 1 (Bcl2l1), transcript variant 5, mRNA.*ENSGALG0000000621142
BAK1 / BCL2 antagonist/killer 1 / O08734* / Q16611* / Bcl-2 homologous antagonist/killer *ENSGALG0000003149316


Protein motifs (from Interpro)
Interpro ID Name
 IPR002475  Bcl2-like
 IPR003093  Apoptosis regulator, Bcl-2 protein, BH4
 IPR004725  Apoptosis regulator, Bcl-2/ BclX
 IPR013278  Apoptosis regulator, Bcl-2
 IPR020717  Apoptosis regulator, Bcl-2, BH1 motif, conserved site
 IPR020726  Apoptosis regulator, Bcl-2, BH2 motif, conserved site
 IPR020728  Apoptosis regulator, Bcl-2, BH3 motif, conserved site
 IPR020731  Apoptosis regulator, Bcl-2, BH4 motif, conserved site
 IPR026298  Blc2 family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0000902 cell morphogenesis IEA
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001541 ovarian follicle development IEA
 biological_processGO:0001656 metanephros development IEA
 biological_processGO:0001657 ureteric bud development IEA
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0001662 behavioral fear response IEA
 biological_processGO:0001776 leukocyte homeostasis IEA
 biological_processGO:0001782 B cell homeostasis IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0001836 release of cytochrome c from mitochondria IEA
 biological_processGO:0001952 regulation of cell-matrix adhesion IEA
 biological_processGO:0002260 lymphocyte homeostasis IEA
 biological_processGO:0002320 lymphoid progenitor cell differentiation IEA
 biological_processGO:0002326 B cell lineage commitment IEA
 biological_processGO:0002360 T cell lineage commitment IEA
 biological_processGO:0002520 immune system development IEA
 biological_processGO:0002931 response to ischemia IEA
 biological_processGO:0003014 renal system process IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006582 melanin metabolic process IEA
 biological_processGO:0006808 regulation of nitrogen utilization IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007015 actin filament organization IEA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0007569 cell aging IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IBA
 biological_processGO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IEA
 biological_processGO:0008637 apoptotic mitochondrial changes IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0009791 post-embryonic development IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0010039 response to iron ion IEA
 biological_processGO:0010224 response to UV-B IEA
 biological_processGO:0010332 response to gamma radiation IEA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010506 regulation of autophagy IEA
 biological_processGO:0010507 negative regulation of autophagy IEA
 biological_processGO:0010523 negative regulation of calcium ion transport into cytosol IEA
 biological_processGO:0010559 regulation of glycoprotein biosynthetic process IEA
 biological_processGO:0014031 mesenchymal cell development IEA
 biological_processGO:0014042 positive regulation of neuron maturation IEA
 biological_processGO:0014911 positive regulation of smooth muscle cell migration IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0021747 cochlear nucleus development IEA
 biological_processGO:0022612 gland morphogenesis IEA
 biological_processGO:0022898 regulation of transmembrane transporter activity IEA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030183 B cell differentiation IEA
 biological_processGO:0030217 T cell differentiation IEA
 biological_processGO:0030279 negative regulation of ossification IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030318 melanocyte differentiation IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0030890 positive regulation of B cell proliferation IEA
 biological_processGO:0031069 hair follicle morphogenesis IEA
 biological_processGO:0031103 axon regeneration IEA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0032469 endoplasmic reticulum calcium ion homeostasis IEA
 biological_processGO:0032835 glomerulus development IEA
 biological_processGO:0032848 negative regulation of cellular pH reduction IEA
 biological_processGO:0032880 regulation of protein localization IEA
 biological_processGO:0033033 negative regulation of myeloid cell apoptotic process IEA
 biological_processGO:0033077 T cell differentiation in thymus IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0033689 negative regulation of osteoblast proliferation IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0035265 organ growth IEA
 biological_processGO:0040007 growth IEA
 biological_processGO:0040018 positive regulation of multicellular organism growth IEA
 biological_processGO:0042100 B cell proliferation IEA
 biological_processGO:0042149 cellular response to glucose starvation IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043029 T cell homeostasis IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043067 regulation of programmed cell death IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0043375 CD8-positive, alpha-beta T cell lineage commitment IEA
 biological_processGO:0043473 pigmentation IEA
 biological_processGO:0043496 regulation of protein homodimerization activity IEA
 biological_processGO:0043497 regulation of protein heterodimerization activity IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0043583 ear development IEA
 biological_processGO:0045069 regulation of viral genome replication IEA
 biological_processGO:0045636 positive regulation of melanocyte differentiation IEA
 biological_processGO:0045930 negative regulation of mitotic cell cycle IEA
 biological_processGO:0046671 negative regulation of retinal cell programmed cell death IEA
 biological_processGO:0046902 regulation of mitochondrial membrane permeability IEA
 biological_processGO:0048041 focal adhesion assembly IEA
 biological_processGO:0048066 developmental pigmentation IEA
 biological_processGO:0048070 regulation of developmental pigmentation IEA
 biological_processGO:0048087 positive regulation of developmental pigmentation IEA
 biological_processGO:0048536 spleen development IEA
 biological_processGO:0048538 thymus development IEA
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0048546 digestive tract morphogenesis IEA
 biological_processGO:0048589 developmental growth IEA
 biological_processGO:0048599 oocyte development IEA
 biological_processGO:0048743 positive regulation of skeletal muscle fiber development IEA
 biological_processGO:0048753 pigment granule organization IEA
 biological_processGO:0048873 homeostasis of number of cells within a tissue IEA
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0050853 B cell receptor signaling pathway IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051402 neuron apoptotic process IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0051881 regulation of mitochondrial membrane potential IEA
 biological_processGO:0051924 regulation of calcium ion transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
 biological_processGO:0070306 lens fiber cell differentiation TAS
 biological_processGO:0071310 cellular response to organic substance IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0072593 reactive oxygen species metabolic process IEA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle IEA
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2000811 negative regulation of anoikis IEA
 biological_processGO:2001234 negative regulation of apoptotic signaling pathway IEA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISS
 cellular_componentGO:0005741 mitochondrial outer membrane IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0046930 pore complex IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0015267 channel activity IEA
 molecular_functionGO:0016248 channel inhibitor activity IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0051434 BH3 domain binding IEA
 molecular_functionGO:0051721 protein phosphatase 2A binding IEA


Pathways (from Reactome)
Pathway description
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000014537 BMF / bcl-2-modifying factor / Q96LC9* / Mus musculus BCL2 modifying factor (Bmf), transcript variant 3, mRNA.*  / reaction / complex
 ENSGALG00000013039 BID / BH3 interacting domain death agonist / P55957* / P70444* / BH3-interacting domain death agonist BH3-interacting domain death agonist p15 BH3-interacting domain death agonist p13 BH3-i...  / complex / reaction






 

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