Manteia - Molecule gene

ENSMUSG00000024521

Mus musculus

Features

Gene ID:	ENSMUSG00000024521

Biological name :	Pmaip1

Synonyms :	phorbol-12-myristate-13-acetate-induced protein 1 / Pmaip1 / Q9JM54

Possible biological names infered from orthology :	Q13794

Species:	Mus musculus

Chr. number:	18
Strand:	1
Band:	E1
Gene start:	66458604
Gene end:	66465550

Corresponding Affymetrix probe sets:	10456357 (MoGene1.0st) 1418203_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000025399 NCBI entrez gene - 58801 See in Manteia. MGI - MGI:1930146 RefSeq - NM_021451 RefSeq Peptide - NP_067426 swissprot - Q9JM54 Ensembl - ENSMUSG00000024521

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
PMAIP1	ENSG00000141682	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR024140	Phorbol-12-myristate-13-acetate-induced protein 1
IPR036834	Blc2-like superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001836	release of cytochrome c from mitochondria	IDA
biological_process	GO:0006915	apoptotic process	ISO
biological_process	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IDA
biological_process	GO:0006974	cellular response to DNA damage stimulus	IMP
biological_process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IMP
biological_process	GO:0009411	response to UV	IMP
biological_process	GO:0010165	response to X-ray	IMP
biological_process	GO:0010917	negative regulation of mitochondrial membrane potential	IDA
biological_process	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IDA
biological_process	GO:0042981	regulation of apoptotic process	RCA
biological_process	GO:0043029	T cell homeostasis	IMP
biological_process	GO:0043065	positive regulation of apoptotic process	IEA
biological_process	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	IMP
biological_process	GO:0043525	positive regulation of neuron apoptotic process	IMP
biological_process	GO:0048147	negative regulation of fibroblast proliferation	IMP
biological_process	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP
biological_process	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	IMP
biological_process	GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	IMP
cellular_component	GO:0005739	mitochondrion	IDA
molecular_function	GO:0005515	protein binding	IPI

Pathways (from Reactome)

Pathway description

Activation of NOXA and translocation to mitochondria

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0003010	decreased mortality induced by ionizing radiation	"reduced sensitivity to lethal doses of ionizing radiation such as ultraviolet light, X-rays, or gamma rays" [smb:Susan M. Bello , Mouse Genome Informatics Curator, J:88888]	Show Allelic Composition: Kcne1^2J/Kcne1^2J Genetic Background: C57BL/6J-Kcne1^2J/J
MP:0004587	decreased cellular sensitivity to X-ray irradiation	"decreased incidence of cell death following exposure to high levels of X-ray irradiation" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kcne1^2J/Kcne1^2J Genetic Background: C57BL/6J-Kcne1^2J/J
MP:0005068	abnormal NK cell morphology/development	"anomalous structure, differentiation, or number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Icmt^tm1Sgy/Icmt^tm1Sgy Genetic Background: Not Specified Allelic Composition: Bcl2l11^tm1.1Ast/Bcl2l11^tm1.1Ast,Pmaip1^tm1Ast/Pmaip1^tm1Ast Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0008411	decreased cellular sensitivity to ultraviolet irradiation	"reduced incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kcne1^2J/Kcne1^2J Genetic Background: C57BL/6J-Kcne1^2J/J
MP:0008944	decreased sensitivity to induced cell death	"increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kcne1^2J/Kcne1^2J Genetic Background: C57BL/6J-Kcne1^2J/J Allelic Composition: Pmaip1^tm1Ast/Pmaip1^tm1Ast Genetic Background: C57BL/6-Pmaip1^tm1Ast

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000007659	Bcl2l1 / Q64373 / Mus musculus BCL2-like 1 (Bcl2l1), transcript variant 5, mRNA. / Q07817* / BCL2 like 1*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr