ENSG00000141682


Homo sapiens

Features
Gene ID: ENSG00000141682
  
Biological name :PMAIP1
  
Synonyms : phorbol-12-myristate-13-acetate-induced protein 1 / PMAIP1 / Q13794
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: 1
Band: q21.32
Gene start: 59899948
Gene end: 59904306
  
Corresponding Affymetrix probe sets: 204285_s_at (Human Genome U133 Plus 2.0 Array)   204286_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000269518
Ensembl peptide - ENSP00000326119
NCBI entrez gene - 5366     See in Manteia.
OMIM - 604959
RefSeq - NM_021127
RefSeq Peptide - NP_066950
swissprot - A0A0S2Z4V2
swissprot - A0A0S2Z490
swissprot - Q13794
Ensembl - ENSG00000141682
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Pmaip1ENSMUSG00000024521Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR024140  Phorbol-12-myristate-13-acetate-induced protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001836 release of cytochrome c from mitochondria IEA
 biological_processGO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
 biological_processGO:0006915 apoptotic process IMP
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0010498 proteasomal protein catabolic process IDA
 biological_processGO:0010907 positive regulation of glucose metabolic process IDA
 biological_processGO:0010917 negative regulation of mitochondrial membrane potential ISS
 biological_processGO:0032461 positive regulation of protein oligomerization IDA
 biological_processGO:0042149 cellular response to glucose starvation IMP
 biological_processGO:0042981 regulation of apoptotic process TAS
 biological_processGO:0043029 T cell homeostasis ISS
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0043331 response to dsRNA IDA
 biological_processGO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator IMP
 biological_processGO:0046902 regulation of mitochondrial membrane permeability IDA
 biological_processGO:0051607 defense response to virus IDA
 biological_processGO:0071456 cellular response to hypoxia IEP
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IMP
 biological_processGO:0072593 reactive oxygen species metabolic process IDA
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria IDA
 biological_processGO:0097193 intrinsic apoptotic signaling pathway IDA
 biological_processGO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
 biological_processGO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
 biological_processGO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway TAS
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane TAS
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Activation of NOXA and translocation to mitochondria
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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