ENSMUSG00000046709


Mus musculus

Features
Gene ID: ENSMUSG00000046709
  
Biological name :Mapk10
  
Synonyms : Mapk10 / mitogen-activated protein kinase 10 isoform 1x
  
Possible biological names infered from orthology : mitogen-activated protein kinase 10 / P53779
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: E5
Gene start: 102907948
Gene end: 103211334
  
Corresponding Affymetrix probe sets: 10531866 (MoGene1.0st)   10531869 (MoGene1.0st)   1437195_x_at (Mouse Genome 430 2.0 Array)   1448342_at (Mouse Genome 430 2.0 Array)   1458513_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127193
Ensembl peptide - ENSMUSP00000108469
Ensembl peptide - ENSMUSP00000142798
Ensembl peptide - ENSMUSP00000143609
Ensembl peptide - ENSMUSP00000143448
Ensembl peptide - ENSMUSP00000084065
Ensembl peptide - ENSMUSP00000108467
Ensembl peptide - ENSMUSP00000108468
NCBI entrez gene - 26414     See in Manteia.
MGI - MGI:1346863
RefSeq - XM_017320891
RefSeq - NM_001081567
RefSeq - NM_001310683
RefSeq - NM_001310685
RefSeq - NM_001310686
RefSeq - NM_001318102
RefSeq - NM_001318131
RefSeq - NM_009158
RefSeq - XM_006534950
RefSeq - XM_011249450
RefSeq - XM_017320886
RefSeq - XM_017320888
RefSeq - XM_017320889
RefSeq - XM_017320890
RefSeq Peptide - NP_001297615
RefSeq Peptide - NP_001305031
RefSeq Peptide - NP_001305060
RefSeq Peptide - NP_033184
RefSeq Peptide - NP_001075036
RefSeq Peptide - NP_001297612
RefSeq Peptide - NP_001297614
swissprot - Q3TQZ7
swissprot - Q80W80
swissprot - Q80W82
swissprot - E9QN59
swissprot - A0A0G2JGL2
swissprot - A0A0G2JG69
swissprot - Q8C9D4
swissprot - A0A0G2JEJ8
Ensembl - ENSMUSG00000046709
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapk10ENSDARG00000102730Danio rerio
 MAPK10ENSGALG00000011109Gallus gallus
 MAPK10ENSG00000109339Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mapk8 / Q91Y86 / Mitogen-activated protein kinase 8 / P45983*ENSMUSG0000002193682
Mapk9 / Q9WTU6 / Mitogen-activated protein kinase 9 / P45984*ENSMUSG0000002036678
Mapk11 / Q9WUI1 / Mitogen-activated protein kinase 11 / Q15759*ENSMUSG0000005313738
Mapk12 / O08911 / Mitogen-activated protein kinase 12 / P53778*ENSMUSG0000002261038
Mapk14 / P47811 / Mitogen-activated protein kinase 14 / Q16539*ENSMUSG0000005343637
Mapk13 / Q9Z1B7 / Mitogen-activated protein kinase 13 / O15264*ENSMUSG0000000486436


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003527  Mitogen-activated protein (MAP) kinase, conserved site
 IPR008271  Serine/threonine-protein kinase, active site
 IPR008351  Mitogen-activated protein (MAP) kinase, JNK
 IPR011009  Protein kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004707 MAP kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Activation of the AP-1 family of transcription factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001051 abnormal somatic motor system morphology 
Show

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Mapk10tm1Flv/Mapk10tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: B6.129S-Mapk9tm1Flv Mapk10tm1Flv

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0001905 abnormal dopamine level "greater or less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Mapk10tm1Flv/Mapk10tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: B6.129S-Mapk9tm1Flv Mapk10tm1Flv

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0002887 resistance to pharmacologically induced seizures "ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:77284]
Show

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008236 decreased susceptibility to neuronal excitotoxicity "less than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0011452 decreased susceptibility to dopaminergic neuron neurotoxicity "less than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [MGI:csmith]
Show

Allelic Composition: Fdft1tm1Kan/Fdft1tm1Kan,Cnptm1(cre)Kan/Cnp+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Mapk10tm1Flv/Mapk10tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: B6.129S-Mapk9tm1Flv Mapk10tm1Flv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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