Manteia

ENSG00000109339

Homo sapiens

Features

Gene ID:	ENSG00000109339

Biological name :	MAPK10

Synonyms :	MAPK10 / mitogen-activated protein kinase 10 / P53779

Possible biological names infered from orthology :

Species:	Homo sapiens

Chr. number:	4
Strand:	-1
Band:	q21.3
Gene start:	85990007
Gene end:	86594625

Corresponding Affymetrix probe sets:	204813_at (Human Genome U133 Plus 2.0 Array) 214376_at (Human Genome U133 Plus 2.0 Array) 237413_at (Human Genome U133 Plus 2.0 Array)

Cross references:	Ensembl peptide - ENSP00000493094 Ensembl peptide - ENSP00000493455 Ensembl peptide - ENSP00000493451 Ensembl peptide - ENSP00000493450 Ensembl peptide - ENSP00000493447 Ensembl peptide - ENSP00000493444 Ensembl peptide - ENSP00000493435 Ensembl peptide - ENSP00000493428 Ensembl peptide - ENSP00000493426 Ensembl peptide - ENSP00000493414 Ensembl peptide - ENSP00000493413 Ensembl peptide - ENSP00000493409 Ensembl peptide - ENSP00000493408 Ensembl peptide - ENSP00000493407 Ensembl peptide - ENSP00000493403 Ensembl peptide - ENSP00000493400 Ensembl peptide - ENSP00000493396 Ensembl peptide - ENSP00000493395 Ensembl peptide - ENSP00000493394 Ensembl peptide - ENSP00000493381 Ensembl peptide - ENSP00000493378 Ensembl peptide - ENSP00000493377 Ensembl peptide - ENSP00000493375 Ensembl peptide - ENSP00000493374 Ensembl peptide - ENSP00000493373 Ensembl peptide - ENSP00000493368 Ensembl peptide - ENSP00000493363 Ensembl peptide - ENSP00000493361 Ensembl peptide - ENSP00000493360 Ensembl peptide - ENSP00000493358 Ensembl peptide - ENSP00000493356 Ensembl peptide - ENSP00000493350 Ensembl peptide - ENSP00000493344 Ensembl peptide - ENSP00000493339 Ensembl peptide - ENSP00000493336 Ensembl peptide - ENSP00000493329 Ensembl peptide - ENSP00000493313 Ensembl peptide - ENSP00000493310 Ensembl peptide - ENSP00000493309 Ensembl peptide - ENSP00000493306 Ensembl peptide - ENSP00000493294 Ensembl peptide - ENSP00000493290 Ensembl peptide - ENSP00000493282 Ensembl peptide - ENSP00000493275 Ensembl peptide - ENSP00000493274 Ensembl peptide - ENSP00000493270 Ensembl peptide - ENSP00000493259 Ensembl peptide - ENSP00000493258 Ensembl peptide - ENSP00000493249 Ensembl peptide - ENSP00000493239 Ensembl peptide - ENSP00000493237 Ensembl peptide - ENSP00000493225 Ensembl peptide - ENSP00000493215 Ensembl peptide - ENSP00000493214 Ensembl peptide - ENSP00000493210 Ensembl peptide - ENSP00000493208 Ensembl peptide - ENSP00000493206 Ensembl peptide - ENSP00000493204 Ensembl peptide - ENSP00000493199 Ensembl peptide - ENSP00000493178 Ensembl peptide - ENSP00000493177 Ensembl peptide - ENSP00000493176 Ensembl peptide - ENSP00000493169 Ensembl peptide - ENSP00000493168 Ensembl peptide - ENSP00000493165 Ensembl peptide - ENSP00000493163 Ensembl peptide - ENSP00000493125 Ensembl peptide - ENSP00000493117 Ensembl peptide - ENSP00000493105 Ensembl peptide - ENSP00000493100 Ensembl peptide - ENSP00000309857 Ensembl peptide - ENSP00000352157 Ensembl peptide - ENSP00000355297 Ensembl peptide - ENSP00000378586 Ensembl peptide - ENSP00000378589 Ensembl peptide - ENSP00000378595 Ensembl peptide - ENSP00000378598 Ensembl peptide - ENSP00000414469 Ensembl peptide - ENSP00000420987 Ensembl peptide - ENSP00000421409 Ensembl peptide - ENSP00000421762 Ensembl peptide - ENSP00000422277 Ensembl peptide - ENSP00000422985 Ensembl peptide - ENSP00000423918 Ensembl peptide - ENSP00000424128 Ensembl peptide - ENSP00000424154 Ensembl peptide - ENSP00000424755 Ensembl peptide - ENSP00000425654 Ensembl peptide - ENSP00000490974 Ensembl peptide - ENSP00000491089 Ensembl peptide - ENSP00000491122 Ensembl peptide - ENSP00000491160 Ensembl peptide - ENSP00000491304 Ensembl peptide - ENSP00000491306 Ensembl peptide - ENSP00000491389 Ensembl peptide - ENSP00000491414 Ensembl peptide - ENSP00000491462 Ensembl peptide - ENSP00000491626 Ensembl peptide - ENSP00000491686 Ensembl peptide - ENSP00000491866 Ensembl peptide - ENSP00000491938 Ensembl peptide - ENSP00000492204 Ensembl peptide - ENSP00000492213 Ensembl peptide - ENSP00000492231 Ensembl peptide - ENSP00000492266 Ensembl peptide - ENSP00000492292 Ensembl peptide - ENSP00000492484 Ensembl peptide - ENSP00000492508 Ensembl peptide - ENSP00000492593 Ensembl peptide - ENSP00000492809 Ensembl peptide - ENSP00000492886 Ensembl peptide - ENSP00000492888 Ensembl peptide - ENSP00000492898 Ensembl peptide - ENSP00000492903 Ensembl peptide - ENSP00000492904 Ensembl peptide - ENSP00000492912 Ensembl peptide - ENSP00000492913 Ensembl peptide - ENSP00000492920 Ensembl peptide - ENSP00000492922 Ensembl peptide - ENSP00000492926 Ensembl peptide - ENSP00000492929 Ensembl peptide - ENSP00000492938 Ensembl peptide - ENSP00000492941 Ensembl peptide - ENSP00000492942 Ensembl peptide - ENSP00000492956 Ensembl peptide - ENSP00000492967 Ensembl peptide - ENSP00000492972 Ensembl peptide - ENSP00000492976 Ensembl peptide - ENSP00000492980 Ensembl peptide - ENSP00000492988 Ensembl peptide - ENSP00000492996 Ensembl peptide - ENSP00000492998 Ensembl peptide - ENSP00000493001 Ensembl peptide - ENSP00000493008 Ensembl peptide - ENSP00000493009 Ensembl peptide - ENSP00000493013 Ensembl peptide - ENSP00000493022 Ensembl peptide - ENSP00000493030 Ensembl peptide - ENSP00000493032 Ensembl peptide - ENSP00000493038 Ensembl peptide - ENSP00000493040 Ensembl peptide - ENSP00000493045 Ensembl peptide - ENSP00000493048 Ensembl peptide - ENSP00000493049 Ensembl peptide - ENSP00000493051 Ensembl peptide - ENSP00000493064 Ensembl peptide - ENSP00000493067 Ensembl peptide - ENSP00000493072 Ensembl peptide - ENSP00000493078 Ensembl peptide - ENSP00000493080 Ensembl peptide - ENSP00000493092 NCBI entrez gene - 5602 See in Manteia. OMIM - 602897 RefSeq - NM_001318069 RefSeq - NM_002753 RefSeq - NM_138980 RefSeq - NM_138982 RefSeq - XM_017008454 RefSeq - XM_017008447 RefSeq - XM_017008448 RefSeq - XM_017008449 RefSeq - XM_017008450 RefSeq - XM_017008451 RefSeq - XM_017008452 RefSeq - XM_017008453 RefSeq - NM_001318068 RefSeq - NM_001318067 RefSeq - XM_005263129 RefSeq - XM_005263130 RefSeq - XM_005263131 RefSeq - XM_005263135 RefSeq - XM_006714268 RefSeq - XM_006714269 RefSeq - XM_011532117 RefSeq - XM_011532118 RefSeq - XM_011532120 RefSeq - XM_011532121 RefSeq - XM_017008419 RefSeq - XM_017008420 RefSeq - XM_017008421 RefSeq - XM_017008422 RefSeq - XM_017008423 RefSeq - XM_017008424 RefSeq - XM_017008425 RefSeq - XM_017008426 RefSeq - XM_017008427 RefSeq - XM_017008428 RefSeq - XM_017008429 RefSeq - XM_017008430 RefSeq - XM_017008431 RefSeq - XM_017008432 RefSeq - XM_017008433 RefSeq - XM_017008434 RefSeq - XM_017008435 RefSeq - XM_017008436 RefSeq - XM_017008437 RefSeq - XM_017008438 RefSeq - XM_017008439 RefSeq - XM_017008440 RefSeq - XM_017008441 RefSeq - XM_017008442 RefSeq - XM_017008443 RefSeq - XM_017008444 RefSeq - XM_017008445 RefSeq - XM_017008446 RefSeq Peptide - NP_001304997 RefSeq Peptide - NP_001304998 RefSeq Peptide - NP_001338553 RefSeq Peptide - NP_001338554 RefSeq Peptide - NP_002744 RefSeq Peptide - NP_620446 RefSeq Peptide - NP_620448 RefSeq Peptide - NP_001304996 swissprot - A0A1W2PQX4 swissprot - A0A1W2PQ03 swissprot - A0A1W2PPZ3 swissprot - A0A1W2PPW1 swissprot - D6RJF9 swissprot - A0A1W2PNF5 swissprot - A0A1P0B7D2 swissprot - P53779 swissprot - Q499Y8 swissprot - A0A1W2PPM4 swissprot - D6RFZ7 swissprot - D6RFX8 swissprot - D6RDG1 swissprot - D6RCB1 swissprot - D6RC26 swissprot - D6RBH2 swissprot - D6RAU3 swissprot - D6RAJ0 swissprot - D6R9C1 swissprot - A8MWW6 swissprot - A8MPV1 swissprot - A0A286YFN2 swissprot - A0A286YFM6 swissprot - A0A286YFK3 swissprot - A0A286YFJ6 swissprot - A0A286YFJ4 swissprot - A0A286YFJ0 swissprot - A0A286YFI3 swissprot - A0A286YFH4 swissprot - A0A286YFE9 swissprot - A0A286YFE2 swissprot - A0A286YFD9 swissprot - A0A286YFD7 swissprot - A0A286YFC3 swissprot - A0A286YFC0 swissprot - A0A286YFB7 swissprot - A0A286YFB6 swissprot - A0A286YFA7 swissprot - A0A286YFA6 swissprot - A0A286YFA3 swissprot - A0A286YF97 swissprot - A0A286YF95 swissprot - A0A286YF85 swissprot - A0A286YF83 swissprot - A0A286YF80 swissprot - A0A286YF62 swissprot - A0A286YF53 swissprot - A0A286YF43 swissprot - A0A286YF35 swissprot - A0A286YF19 swissprot - A0A286YF04 swissprot - A0A286YF02 swissprot - A0A286YEZ1 swissprot - A0A286YEY2 swissprot - A0A286YEY0 swissprot - A0A286YEX7 swissprot - A0A286YEW9 swissprot - A0A286YEW4 swissprot - A0A286YEV8 swissprot - A0A286YEV5 swissprot - A0A286YEV3 swissprot - A0A286YES9 swissprot - A0A286YES8 swissprot - A0A286YES0 swissprot - A0A286YEQ7 swissprot - A0A286YEQ0 swissprot - A0A286YEN5 swissprot - A0A1W2PRZ2 swissprot - A0A1W2PRG9 swissprot - A0A1W2PRF2 Ensembl - ENSG00000109339

See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
mapk10	ENSDARG00000102730	Danio rerio
MAPK10	ENSGALG00000011109	Gallus gallus
Mapk10	ENSMUSG00000046709	Mus musculus

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
MAPK8 / P45983 / mitogen-activated protein kinase 8	ENSG00000107643	83
MAPK9 / P45984 / mitogen-activated protein kinase 9	ENSG00000050748	77
MAPK11 / Q15759 / mitogen-activated protein kinase 11	ENSG00000185386	38
MAPK13 / O15264 / mitogen-activated protein kinase 13	ENSG00000156711	37
MAPK12 / P53778 / mitogen-activated protein kinase 12	ENSG00000188130	37
MAPK14 / Q16539 / mitogen-activated protein kinase 14	ENSG00000112062	37

Protein motifs (from Interpro)

Interpro ID	Name
IPR000719	Protein kinase domain
IPR003527	Mitogen-activated protein (MAP) kinase, conserved site
IPR008271	Serine/threonine-protein kinase, active site
IPR008351	Mitogen-activated protein (MAP) kinase, JNK
IPR011009	Protein kinase-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000165	MAPK cascade	IEA
biological_process	GO:0000187	activation of MAPK activity	IEA
biological_process	GO:0006468	protein phosphorylation	ISS
biological_process	GO:0007165	signal transduction	TAS
biological_process	GO:0007254	JNK cascade	IBA
biological_process	GO:0007258	JUN phosphorylation	IEA
biological_process	GO:0009416	response to light stimulus	ISS
biological_process	GO:0010468	regulation of gene expression	IBA
biological_process	GO:0016310	phosphorylation	IEA
biological_process	GO:0038095	Fc-epsilon receptor signaling pathway	TAS
biological_process	GO:0042752	regulation of circadian rhythm	ISS
biological_process	GO:0048511	rhythmic process	IEA
biological_process	GO:0048666	neuron development	IBA
biological_process	GO:0051090	regulation of DNA-binding transcription factor activity	TAS
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005634	nucleus	IBA
cellular_component	GO:0005654	nucleoplasm	TAS
cellular_component	GO:0005737	cytoplasm	IBA
cellular_component	GO:0005739	mitochondrion	ISS
cellular_component	GO:0005829	cytosol	TAS
cellular_component	GO:0005886	plasma membrane	ISS
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0043005	neuron projection	IBA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0004672	protein kinase activity	IEA
molecular_function	GO:0004674	protein serine/threonine kinase activity	IEA
molecular_function	GO:0004705	JUN kinase activity	TAS
molecular_function	GO:0004707	MAP kinase activity	IEA
molecular_function	GO:0004708	MAP kinase kinase activity	TAS
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016301	kinase activity	IEA
molecular_function	GO:0016740	transferase activity	IEA

Pathways (from Reactome)

Pathway description

Oxidative Stress Induced Senescence

FCERI mediated MAPK activation

JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1

Activation of the AP-1 family of transcription factors

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
HP:0000718	Aggressive behavior	"Aggressive behavior can denote verbal aggression, physical aggression against objects, physical aggression against people, and may also include aggression towards oneself." [HPO:curators]	Show
HP:0000729	Pervasive developmental disorder		Show
HP:0000752	Hyperactivity		Show
HP:0001249	Mental retardation		Show
HP:0001268	Mental deterioration		Show
HP:0001298	Encephalopathy		Show
HP:0001336	Myoclonus	"Very brief, involuntary random muscular contractions occurring at rest, in response to sensory stimuli, or accompanying voluntary movements." [HPO:curators]	Show
HP:0002069	Generalized tonic-clonic seizures	"Generalized tonic-clonic seizures are `generalized seizures` (HP:0002197) in which the patient suddenly loses conciousness, the eyes roll back, and the entire body musculature undergoes tonic contractions. In the clonic phase of the seizure, there are rhythmic contractions of the musculature alternating with relaxation of all muscle groups. Loss of sphincter control during the seizure is common. This form of seizure was formerly commonly called grand mal seizure." [HPO:curators]	Show
HP:0002123	Myoclonic seizures	"Myoclonic seizures are sudden, brief losses of consciousness and postural tone not associated with tonic muscular contractions. Myoclonic seizures may involve one body part or the entire body. In the latter case, the myoclonic seizure is accompanied by a violent fall but not by loss of consciousness." [HPO:curators]	Show
HP:0002363	Abnormality of the brainstem		Show
HP:0002527	Falls		Show
HP:0007270	Atypical absence seizures		Show
HP:0007359	Partial seizures	"Recurrent partial `seizures` (HP:0001250). In a partial seizure, the electrical disturbance is limited to one part or side of the brain. That is, partial epilepsies are epileptic disorders in which clinical or laboratory findings disclose a localized origin of seizures." [HPO:curators]	Show
HP:0010818	Tonic seizures	"A type of `seizure` (HP:0001250) characterized by a sudden increase in muscle tone whereby the body, arms, or legs make sudden stiffening movements and consciousness is usually preserved. Tonic seizures can occur during sleep. Tonic seizures usually affect both sides of the body, and cause a fall if the affected person was standing when the seizure started." [HPO:probinson]	Show
HP:0010819	Atonic seizures	"A type of `seizure` (HP:0001250) characterized by a suddenloss of musle tone. Usually, consciousness is retained. In an atonic seizure, the eyelids may droop, the head may nod, and the person may drop things and fall to the ground." [HPO:probinson]	Show
HP:0011195	EEG with focal sharp slow waves	"EEG with focal sharp transient waves of a duration between 80 and 200 msec followed by a slow wave." [HPO:jalbers]	Show
HP:0012075	Personality disorder	"An abnormality of mental functioning affecting the personality and behavioural tendencies of an individual and characterized by a rigid and unhealthy pattern of thinking and behavior. The definition of a personal disorder implies that the abnormality is not the result of damage or insult to the brain or from another psychiatric disorder." [HPO:probinson]	Show

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSG00000177606	JUN / P05412 / Jun proto-oncogene, AP-1 transcription factor subunit	/ reaction
ENSG00000115966	ATF2 / P15336 / activating transcription factor 2	/ reaction
ENSG00000065559	MAP2K4 / P45985 / mitogen-activated protein kinase kinase 4	/ reaction
ENSG00000076984	MAP2K7 / O14733 / mitogen-activated protein kinase kinase 7	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr