ENSG00000177606


Homo sapiens

Features
Gene ID: ENSG00000177606
  
Biological name :JUN
  
Synonyms : JUN / Jun proto-oncogene, AP-1 transcription factor subunit / P05412
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p32.1
Gene start: 58780788
Gene end: 58784327
  
Corresponding Affymetrix probe sets: 201464_x_at (Human Genome U133 Plus 2.0 Array)   201465_s_at (Human Genome U133 Plus 2.0 Array)   201466_s_at (Human Genome U133 Plus 2.0 Array)   213281_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000360266
NCBI entrez gene - 3725     See in Manteia.
OMIM - 165160
RefSeq - NM_002228
RefSeq Peptide - NP_002219
swissprot - P05412
Ensembl - ENSG00000177606
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 junENSDARG00000043531Danio rerio
 JUNENSGALG00000010870Gallus gallus
 JunENSMUSG00000052684Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
JUND / P17535 / JunD proto-oncogene, AP-1 transcription factor subunitENSG0000013052252
JUNB / P17275 / JunB proto-oncogene, AP-1 transcription factor subunitENSG0000017122347


Protein motifs (from Interpro)
Interpro ID Name
 IPR002112  Transcription factor Jun
 IPR004827  Basic-leucine zipper domain
 IPR005643  Jun-like transcription factor
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR015558  Transcription Factor c-Jun/v-Jun


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001774 microglial cell activation IEA
 biological_processGO:0001836 release of cytochrome c from mitochondria IEA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0003151 outflow tract morphogenesis IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0007265 Ras protein signal transduction IDA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007612 learning IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009987 cellular process IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010634 positive regulation of epithelial cell migration IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0030224 monocyte differentiation IEA
 biological_processGO:0031103 axon regeneration IEA
 biological_processGO:0031953 negative regulation of protein autophosphorylation IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0034614 cellular response to reactive oxygen species IMP
 biological_processGO:0035026 leading edge cell differentiation IEA
 biological_processGO:0035994 response to muscle stretch IEA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043392 negative regulation of DNA binding IDA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0043922 negative regulation by host of viral transcription IDA
 biological_processGO:0043923 positive regulation by host of viral transcription IDA
 biological_processGO:0045597 positive regulation of cell differentiation IBA
 biological_processGO:0045657 positive regulation of monocyte differentiation IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0051090 regulation of DNA-binding transcription factor activity TAS
 biological_processGO:0051365 cellular response to potassium ion starvation IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0051899 membrane depolarization IEA
 biological_processGO:0060395 SMAD protein signal transduction IDA
 biological_processGO:0061029 eyelid development in camera-type eye IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0071276 cellular response to cadmium ion IMP
 biological_processGO:0071277 cellular response to calcium ion IEA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IMP
 biological_processGO:1990441 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IMP
 biological_processGO:2000144 positive regulation of DNA-templated transcription, initiation IDA
 cellular_componentGO:0000228 nuclear chromosome TAS
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IEA
 cellular_componentGO:0005719 nuclear euchromatin IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0017053 transcriptional repressor complex IEA
 cellular_componentGO:0035976 transcription factor AP-1 complex IMP
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IC
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IPI
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IC
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005096 GTPase activator activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0033613 activating transcription factor binding IEA
 molecular_functionGO:0035497 cAMP response element binding IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0070412 R-SMAD binding IPI
 molecular_functionGO:0071837 HMG box domain binding IEA


Pathways (from Reactome)
Pathway description
Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated MAPK activation
Activation of the AP-1 family of transcription factors
Activation of anterior HOX genes in hindbrain development during early embryogenesis
MAPK6/MAPK4 signaling
TP53 Regulates Transcription of DNA Repair Genes
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimers disease models
Regulation of PTEN gene transcription
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000109339 MAPK10 / P53779 / mitogen-activated protein kinase 10  / reaction
 ENSG00000170345 FOS / P01100 / Fos proto-oncogene, AP-1 transcription factor subunit  / complex / reaction
 ENSG00000164885 CDK5 / Q00535 / cyclin dependent kinase 5  / reaction
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction / complex
 ENSG00000050748 MAPK9 / P45984 / mitogen-activated protein kinase 9  / reaction
 ENSG00000107643 MAPK8 / P45983 / mitogen-activated protein kinase 8  / reaction
 ENSG00000204103 MAFB / Q9Y5Q3 / MAF bZIP transcription factor B  / complex
 ENSG00000115966 ATF2 / P15336 / activating transcription factor 2  / reaction / complex
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / complex






 

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