ENSG00000171223


Homo sapiens

Features
Gene ID: ENSG00000171223
  
Biological name :JUNB
  
Synonyms : JUNB / JunB proto-oncogene, AP-1 transcription factor subunit / P17275
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.13
Gene start: 12791496
Gene end: 12793315
  
Corresponding Affymetrix probe sets: 201473_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000303315
NCBI entrez gene - 3726     See in Manteia.
OMIM - 165161
RefSeq - NM_002229
RefSeq Peptide - NP_002220
swissprot - P17275
swissprot - Q5U079
Ensembl - ENSG00000171223
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 junbaENSDARG00000074378Danio rerio
 junbbENSDARG00000104773Danio rerio
 ENSGALG00000041930Gallus gallus
 JunbENSMUSG00000052837Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
JUN / P05412 / Jun proto-oncogene, AP-1 transcription factor subunitENSG0000017760644
JUND / P17535 / JunD proto-oncogene, AP-1 transcription factor subunitENSG0000013052242


Protein motifs (from Interpro)
Interpro ID Name
 IPR002112  Transcription factor Jun
 IPR004827  Basic-leucine zipper domain
 IPR005643  Jun-like transcription factor
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR029822  Transcription factor JunB


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0001570 vasculogenesis IEA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001829 trophectodermal cell differentiation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0009314 response to radiation IBA
 biological_processGO:0009612 response to mechanical stimulus IBA
 biological_processGO:0009987 cellular process IEA
 biological_processGO:0010941 regulation of cell death IBA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030316 osteoclast differentiation IEA
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:0033687 osteoblast proliferation IEA
 biological_processGO:0034097 response to cytokine IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042493 response to drug IBA
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046697 decidualization IEA
 biological_processGO:0051591 response to cAMP IBA
 biological_processGO:0051726 regulation of cell cycle IBA
 biological_processGO:0060136 embryonic process involved in female pregnancy IEA
 biological_processGO:0060716 labyrinthine layer blood vessel development IEA
 biological_processGO:0071277 cellular response to calcium ion IEA
 cellular_componentGO:0000785 chromatin TAS
 cellular_componentGO:0000790 nuclear chromatin IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0035976 transcription factor AP-1 complex IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity TAS
 molecular_functionGO:0003714 transcription corepressor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IBA


Pathways (from Reactome)
Pathway description
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Interleukin-4 and Interleukin-13 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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