ENSG00000130522


Homo sapiens

Features
Gene ID: ENSG00000130522
  
Biological name :JUND
  
Synonyms : JUND / JunD proto-oncogene, AP-1 transcription factor subunit / P17535
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.11
Gene start: 18279760
Gene end: 18281622
  
Corresponding Affymetrix probe sets: 203751_x_at (Human Genome U133 Plus 2.0 Array)   203752_s_at (Human Genome U133 Plus 2.0 Array)   214326_x_at (Human Genome U133 Plus 2.0 Array)   229117_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000252818
Ensembl peptide - ENSP00000475153
NCBI entrez gene - 3727     See in Manteia.
OMIM - 165162
RefSeq - NM_005354
RefSeq - NM_001286968
RefSeq Peptide - NP_001273897
RefSeq Peptide - NP_005345
swissprot - P17535
swissprot - U3KPR5
Ensembl - ENSG00000130522
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 jundENSDARG00000067850Danio rerio
 JUNDENSGALG00000043641Gallus gallus
 JundENSMUSG00000071076Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
JUN / P05412 / Jun proto-oncogene, AP-1 transcription factor subunitENSG0000017760650
JUNB / P17275 / JunB proto-oncogene, AP-1 transcription factor subunitENSG0000017122342


Protein motifs (from Interpro)
Interpro ID Name
 IPR002112  Transcription factor Jun
 IPR004827  Basic-leucine zipper domain
 IPR005643  Jun-like transcription factor
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR029823  Transcription factor JunD


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0002076 osteoblast development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0009314 response to radiation IBA
 biological_processGO:0009416 response to light stimulus IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0010941 regulation of cell death IBA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:0034097 response to cytokine IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042493 response to drug IBA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0045597 positive regulation of cell differentiation IBA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051591 response to cAMP IBA
 biological_processGO:0051726 regulation of cell cycle IBA
 biological_processGO:0071277 cellular response to calcium ion IEA
 cellular_componentGO:0000785 chromatin TAS
 cellular_componentGO:0000790 nuclear chromatin IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0032993 protein-DNA complex IEA
 cellular_componentGO:0035976 transcription factor AP-1 complex IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016922 nuclear receptor binding IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000125740 FOSB / P53539 / FosB proto-oncogene, AP-1 transcription factor subunit  / complex
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / complex / reaction






 

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