ENSG00000125740


Homo sapiens

Features
Gene ID: ENSG00000125740
  
Biological name :FOSB
  
Synonyms : FOSB / FosB proto-oncogene, AP-1 transcription factor subunit / P53539
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.32
Gene start: 45467995
Gene end: 45475179
  
Corresponding Affymetrix probe sets: 202768_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000468207
Ensembl peptide - ENSP00000468482
Ensembl peptide - ENSP00000485018
Ensembl peptide - ENSP00000245919
Ensembl peptide - ENSP00000407207
Ensembl peptide - ENSP00000414177
Ensembl peptide - ENSP00000465068
Ensembl peptide - ENSP00000465528
Ensembl peptide - ENSP00000465552
Ensembl peptide - ENSP00000466530
Ensembl peptide - ENSP00000467497
NCBI entrez gene - 2354     See in Manteia.
OMIM - 164772
RefSeq - XM_005258691
RefSeq - NM_001114171
RefSeq - NM_006732
RefSeq Peptide - NP_001107643
RefSeq Peptide - NP_006723
swissprot - P53539
swissprot - A0A024R0P6
swissprot - K7EJ89
swissprot - K7EKC1
swissprot - K7EKA0
swissprot - K7ERZ8
Ensembl - ENSG00000125740
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fosbENSDARG00000055751Danio rerio
 FosbENSMUSG00000003545Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FOS / P01100 / Fos proto-oncogene, AP-1 transcription factor subunitENSG0000017034543
FOSL2 / P15408 / FOS like 2, AP-1 transcription factor subunitENSG0000007542639
FOSL1 / P15407 / FOS like 1, AP-1 transcription factor subunitENSG0000017559232


Protein motifs (from Interpro)
Interpro ID Name
 IPR000837  AP-1 transcription factor
 IPR004827  Basic-leucine zipper domain
 IPR029813  Protein FosB


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0032870 cellular response to hormone stimulus IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051412 response to corticosterone IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0071277 cellular response to calcium ion IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008134 transcription factor binding TAS
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000130522 JUND / P17535 / JunD proto-oncogene, AP-1 transcription factor subunit  / complex
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / reaction / complex






 

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