ENSMUSG00000003545


Mus musculus

Features
Gene ID: ENSMUSG00000003545
  
Biological name :Fosb
  
Synonyms : Fosb / P13346 / Protein fosB
  
Possible biological names infered from orthology : FosB proto-oncogene, AP-1 transcription factor subunit / P53539
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A3
Gene start: 19302696
Gene end: 19310051
  
Corresponding Affymetrix probe sets: 10560481 (MoGene1.0st)   1422134_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003640
Ensembl peptide - ENSMUSP00000147210
Ensembl peptide - ENSMUSP00000146949
Ensembl peptide - ENSMUSP00000146789
Ensembl peptide - ENSMUSP00000146569
Ensembl peptide - ENSMUSP00000146525
NCBI entrez gene - 14282     See in Manteia.
MGI - MGI:95575
RefSeq - XM_006539544
RefSeq - NM_008036
RefSeq - XM_006539543
RefSeq Peptide - NP_032062
RefSeq Peptide - NP_001334515
swissprot - A0A140LJH0
swissprot - A2RSD4
swissprot - P13346
swissprot - A0A140LIT4
swissprot - A0A140LHW0
swissprot - A0A140LIE4
swissprot - A0A140LHS3
Ensembl - ENSMUSG00000003545
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fosbENSDARG00000055751Danio rerio
 FOSBENSG00000125740Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fos / P01101 / Proto-onco c-Fos / P01100* / Fos proto-oncogene, AP-1 transcription factor subunit*ENSMUSG0000002125043
Fosl2 / P47930 / Fos-related antigen 2 / P15408* / FOS like 2, AP-1 transcription factor subunit*ENSMUSG0000002913537
Fosl1 / P48755 / Fos-related antigen 1 / P15407* / FOS like 1, AP-1 transcription factor subunit*ENSMUSG0000002491229


Protein motifs (from Interpro)
Interpro ID Name
 IPR000837  AP-1 transcription factor
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR029813  Protein FosB


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0032870 cellular response to hormone stimulus IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043278 response to morphine IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0051412 response to corticosterone IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0071277 cellular response to calcium ion IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Inhbetm2Zuk/Inhbetm2Zuk
Genetic Background: either: (involves: 129S5/SvEvBrd * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
Show

Allelic Composition: Fosbtm1.1Yun/Fosb+
Genetic Background: B6.129S-Fosbtm1.1Yun

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
Show

Allelic Composition: Faap20tm1(KOMP)Mbp/Faap20tm1(KOMP)Mbp,Fancatm1.1Wong/Fancatm1.1Wong
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N

Allelic Composition: Fosbtm1.1Yun/Fosb+
Genetic Background: B6.129S-Fosbtm1.1Yun

 MP:0001382 abnormal nursing "females do not nurse pups or nurse pups infrequently" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Inhbetm2Zuk/Inhbetm2Zuk
Genetic Background: either: (involves: 129S5/SvEvBrd * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0001384 abnormal pup retrieval "a mother does not retrieve stray pups to the nest or delays retrieving stray pups" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Inhbetm2Zuk/Inhbetm2Zuk
Genetic Background: either: (involves: 129S5/SvEvBrd * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
Show

Allelic Composition: Inhbetm2Zuk/Inhbetm2Zuk
Genetic Background: either: (involves: 129S5/SvEvBrd * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Faap20tm1(KOMP)Mbp/Faap20tm1(KOMP)Mbp,Fancatm1.1Wong/Fancatm1.1Wong
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N

Allelic Composition: Fosbtm1.1Yun/Fosb+
Genetic Background: B6.129S-Fosbtm1.1Yun

Allelic Composition: Fosbtm2.1Yun/Fosbtm2.1Yun
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Faap20tm1(KOMP)Mbp/Faap20tm1(KOMP)Mbp,Fancatm1.1Wong/Fancatm1.1Wong
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N

Allelic Composition: Fosbtm1.1Yun/Fosb+
Genetic Background: B6.129S-Fosbtm1.1Yun

Allelic Composition: Fosbtm2.1Yun/Fosbtm2.1Yun
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001650 electrically induced seizures "high or low frequency electrical stimulation applied to induce seizure activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, wf:Wayne Frankel , TJL staff]
Show

Allelic Composition: Inhbetm2Zuk/Inhbetm2Zuk
Genetic Background: either: (involves: 129S5/SvEvBrd * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0001902 reduced NMDA -mediated synaptic currents "reduction in the measured amplitude or duration of response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Inhbetm2Zuk/Inhbetm2Zuk
Genetic Background: either: (involves: 129S5/SvEvBrd * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fosbtm1.1Yun/Fosb+
Genetic Background: B6.129S-Fosbtm1.1Yun

 MP:0002068 abnormal parental behavior "altered behavior of animals towards offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Inhbetm2Zuk/Inhbetm2Zuk
Genetic Background: either: (involves: 129S5/SvEvBrd * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0002572 abnormal emotion/affect behavior "altered response in tests for emotional related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fosbtm1.1Yun/Fosb+
Genetic Background: B6.129S-Fosbtm1.1Yun

 MP:0003194 abnormal frequency of paradoxical sleep "abnormal incidence or duration of the sleep stage in which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Fostm1Pa/Fostm1Pa
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Fosbtm1Meg/Fosb+
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * BALB/c

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Faap20tm1(KOMP)Mbp/Faap20tm1(KOMP)Mbp,Fancatm1.1Wong/Fancatm1.1Wong
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N

Allelic Composition: Fosbtm1.1Yun/Fosb+
Genetic Background: B6.129S-Fosbtm1.1Yun

Allelic Composition: Fosbtm2.1Yun/Fosbtm2.1Yun
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Fosbtm2.1Yun/Fosb+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003360 depression-related behavior 
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Allelic Composition: Fosbtm2.1Yun/Fosbtm2.1Yun
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0012307 impaired spatial learning "impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
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Allelic Composition: Fosbtm2.1Yun/Fosbtm2.1Yun
Genetic Background: involves: 129S/SvEv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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