ENSMUSG00000021250


Mus musculus

Features
Gene ID: ENSMUSG00000021250
  
Biological name :Fos
  
Synonyms : Fos / P01101 / Proto-onco c-Fos
  
Possible biological names infered from orthology : Fos proto-oncogene, AP-1 transcription factor subunit / P01100
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: D2
Gene start: 85473890
Gene end: 85477273
  
Corresponding Affymetrix probe sets: 10397346 (MoGene1.0st)   1423100_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021674
NCBI entrez gene - 14281     See in Manteia.
MGI - MGI:95574
RefSeq - NM_010234
RefSeq Peptide - NP_034364
swissprot - P01101
Ensembl - ENSMUSG00000021250
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fosabENSDARG00000031683Danio rerio
 FOSENSGALG00000028037Gallus gallus
 FOSENSG00000170345Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fosl2 / P47930 / Fos-related antigen 2 / P15408* / FOS like 2, AP-1 transcription factor subunit*ENSMUSG0000002913540
Fosb / P13346 / Protein fosB / P53539* / FosB proto-oncogene, AP-1 transcription factor subunit*ENSMUSG0000000354538
Fosl1 / P48755 / Fos-related antigen 1 / P15407* / FOS like 1, AP-1 transcription factor subunit*ENSMUSG0000002491231


Protein motifs (from Interpro)
Interpro ID Name
 IPR000837  AP-1 transcription factor
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR029816  c-Fos/v-Fos


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001661 conditioned taste aversion IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IMP
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0009409 response to cold IEA
 biological_processGO:0009416 response to light stimulus IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009629 response to gravity IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0030431 sleep IEA
 biological_processGO:0031668 cellular response to extracellular stimulus IMP
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0032870 cellular response to hormone stimulus IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0034614 cellular response to reactive oxygen species IEA
 biological_processGO:0035902 response to immobilization stress IEA
 biological_processGO:0035914 skeletal muscle cell differentiation IMP
 biological_processGO:0035994 response to muscle stretch IDA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045672 positive regulation of osteoclast differentiation IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051412 response to corticosterone IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0060395 SMAD protein signal transduction IEA
 biological_processGO:0071276 cellular response to cadmium ion IEA
 biological_processGO:0071277 cellular response to calcium ion IDA
 biological_processGO:1901216 positive regulation of neuron death IEA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0032993 protein-DNA complex IEA
 cellular_componentGO:0035976 transcription factor AP-1 complex IEA
 cellular_componentGO:0043005 neuron projection IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IEA
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0070412 R-SMAD binding IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
Activation of the AP-1 family of transcription factors
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000065 abnormal bone marrow cavities "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Fostm1Wag/Fostm2(Fosl1)Wag
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000067 osteopetrosis "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Fostm1Wag/Fostm1Wag,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Fostm1Wag/Fostm2(Fosl1)Wag
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000121 failure of tooth eruption "inability of the teeth to grow into the oral cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Fostm1Pa/Fostm1Pa
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Fostm1Wag/Fostm2(Fosl1)Wag
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000124 absent teeth "missing bony structures of the upper and lower jaws used in mastication" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Fostm1Pa/Fostm1Pa
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Fostm1Wag/Fostm2(Fosl1)Wag
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000131 abnormal long bone epiphysis morphology "the head of a developing long bone that is separated from the shaft by the epiphyseal plate" [J:61509]
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Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000133 abnormal long bone metaphysis morphology "malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000134 abnormal cortical bone thickness "reduced or increased width of the superficial layer of compact bone" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppp1r13lwoe2/Ppp1r13lwoe2
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000440 domed skull 
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Allelic Composition: Fostm1Pa/Fostm1Pa
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
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Allelic Composition: Fostm1Pa/Fostm1Pa
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Fostm1Pa/Fostm1Pa
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Fostm1Pa/Fostm1Pa
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Fostm1Pa/Fostm1Pa
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Inhbetm2Zuk/Inhbetm2Zuk
Genetic Background: either: (involves: 129S5/SvEvBrd * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Fostm1Wag/Fostm2(Fosl1)Wag
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0001273 decreased metastatic potential 
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Allelic Composition: Fostm1Pa/Fostm1Pa
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Inhbetm2Zuk/Inhbetm2Zuk
Genetic Background: either: (involves: 129S5/SvEvBrd * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Fostm1Pa/Fostm1Pa
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

Allelic Composition: Fostm1Pa/Fostm1Pa
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Fostm2(Fosl1)Wag/Fostm2(Fosl1)Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Inhbetm2Zuk/Inhbetm2Zuk
Genetic Background: either: (involves: 129S5/SvEvBrd * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0002036 rhabdomyosarcoma "malignant tumor derived from skeletal (striated) muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Fostm1Wag/Fostm1Wag,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Fostm1Wag/Fostm1Wag,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002051 skin papilloma "a circumscribed, benign epithelial tumor projecting from the surrounding surface" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Egfrwa2/Egfr+,Fostm5.1Wag/Fostm5.1Wag,Tg(KRT5-SOS1)892A6Wag/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

Allelic Composition: Egfrwa2/Egfr+,Fostm6.1Wag/Fostm6.1Wag,Tg(KRT5-SOS1)892A6Wag/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

Allelic Composition: Egfrwa2/Egfr+,Fostm3.1Wag/Fostm3.1Wag,Tg(KRT5-SOS1)892A6Wag/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

Allelic Composition: Egfrwa2/Egfr+,Fostm2(Fosl1)Wag/Fostm2(Fosl1)Wag,Tg(KRT5-SOS1)892A6Wag/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Egfrwa2/Egfr+,Fostm4.1Wag/Fostm4.1Wag,Tg(KRT5-SOS1)892A6Wag/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002062 abnormal conditioning behavior "inability to change the frequency or form of a behavior as a result of the influence of the environment " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Ldo/Trp53+
Genetic Background: B6.129S7-Trp53tm1Ldo

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Inhbetm2Zuk/Inhbetm2Zuk
Genetic Background: either: (involves: 129S5/SvEvBrd * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: GckHlb62/?
Genetic Background: C57BL/6J-GckHlb62/J

Allelic Composition: Fostm1.1(cre/ERT2)Luo/Fos+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Fostm1.1Fawa/Fostm1.1Fawa
Genetic Background: involves: 129 * 129S4/SvJae * C57BL/6

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fostm1Pa/Fostm1Pa
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53tm1Ldo/Trp53+
Genetic Background: B6.129S7-Trp53tm1Ldo

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002364 abnormal thymus size "deviation from the normal size of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002401 abnormal lymphopoiesis "atypcial formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; these lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fostm1Pa/Fostm1Pa
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Inhbetm2Zuk/Inhbetm2Zuk
Genetic Background: either: (involves: 129S5/SvEvBrd * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)

 MP:0002673 abnormal sperm count "increased or decreased numbers of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fostm1Pa/Fostm1Pa
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003194 abnormal frequency of paradoxical sleep "abnormal incidence or duration of the sleep stage in which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Fostm1Pa/Fostm1Pa
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Ldo/Trp53+
Genetic Background: B6.129S7-Trp53tm1Ldo

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Egfrwa2/Egfr+,Fostm5.1Wag/Fostm5.1Wag,Tg(KRT5-SOS1)892A6Wag/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

Allelic Composition: Egfrwa2/Egfr+,Fostm3.1Wag/Fostm3.1Wag,Tg(KRT5-SOS1)892A6Wag/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

Allelic Composition: Egfrwa2/Egfr+,Fostm2(Fosl1)Wag/Fostm2(Fosl1)Wag,Tg(KRT5-SOS1)892A6Wag/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Fostm7Wag/Fostm7Wag,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Fostm1Pa/Fostm1Pa
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
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Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Egfrwa2/Egfr+,Fostm6.1Wag/Fostm6.1Wag,Tg(KRT5-SOS1)892A6Wag/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fostm1Pa/Fostm1Pa
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003797 abnormal compact bone morphology "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004179 transmission ratio distortion "the occurence of an allele or haplotype in the offspring of an organism at skewed Mendelian ratios" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas

 MP:0004214 abnormal long bone diaphysis morphology "any structural anomaly of the main or mid section (shaft) of a long bone" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fostm1Pa/Fostm1Pa
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fostm1Pa/Fostm1Pa
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004921 decreased placenta weight "reduction in the weight of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fostm1Pa/Fostm1Pa
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm1Ldo/Trp53+
Genetic Background: B6.129S7-Trp53tm1Ldo

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Fostm1Wag/Fostm2(Fosl1)Wag
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

Allelic Composition: Fostm5.1Wag/Fostm5.1Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0004989 decreased osteoblast cell number "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fostm5.1Wag/Fostm5.1Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Fostm1Pa/Fostm1Pa
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ppp1r13lwoe2/Ppp1r13lwoe2
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0006325 impaired hearing "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fostm1Pa/Fostm1Pa
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0006359 absent startle reflex "failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fostm1Pa/Fostm1Pa
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0006397 disorganized long bone epiphyseal plate "a lack of the regular arrangement of the cells or zones of the epiphyseal plate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fostm1Pa/Fostm1Pa
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fostm7Wag/Fostm7Wag,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm1Ldo/Trp53+
Genetic Background: B6.129S7-Trp53tm1Ldo

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fostm5.1Wag/Fostm5.1Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Fostm6.1Wag/Fostm6.1Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0008453 decreased retinal rod cell number "reduced number of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
Show

Allelic Composition: Fostm1Pa/Fostm1Pa
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fostm1Pa/Fostm1Pa
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fostm1Pa/Fostm1Pa
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Fostm5.1Wag/Fostm5.1Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Fostm6.1Wag/Fostm6.1Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Fostm7Wag/Fostm7Wag,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Apoetm2(APOE*3)Mae/Apoetm2(APOE*3)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fostm4.1Wag/Fostm4.1Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Fostm5.1Wag/Fostm5.1Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Fostm7Wag/Fostm7Wag,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008593 increased circulating interleukin-10 level "increase in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Fostm6.1Wag/Fostm6.1Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Fostm7Wag/Fostm7Wag,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Fostm6.1Wag/Fostm6.1Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Fostm7Wag/Fostm7Wag,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Apoetm2(APOE*3)Mae/Apoetm2(APOE*3)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fostm4.1Wag/Fostm4.1Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Fostm5.1Wag/Fostm5.1Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Fostm7Wag/Fostm7Wag,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Fostm4.1Wag/Fostm4.1Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Fostm5.1Wag/Fostm5.1Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Fostm7Wag/Fostm7Wag,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoetm2(APOE*3)Mae/Apoetm2(APOE*3)Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fostm4.1Wag/Fostm4.1Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Fostm5.1Wag/Fostm5.1Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Fostm6.1Wag/Fostm6.1Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Fostm7Wag/Fostm7Wag,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008946 abnormal neuron number "anomaly in the number of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Trp53tm1Ldo/Trp53+
Genetic Background: B6.129S7-Trp53tm1Ldo

 MP:0009339 decreased splenocyte number "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fostm1Pa/Fostm1Pa
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009712 impaired conditioned place preference behavior "decrease in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm1Ldo/Trp53+
Genetic Background: B6.129S7-Trp53tm1Ldo

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fostm7Wag/Fostm7Wag,Tg(Cd4-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Egfrwa2/Egfr+,Fostm5.1Wag/Fostm5.1Wag,Tg(KRT5-SOS1)892A6Wag/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA * SJL

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Fostm5.1Wag/Fostm5.1Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0010875 increased bone volume "increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fostm5.1Wag/Fostm5.1Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0011078 increased macrophage cytokine production "greater production of macrophage-derived cytokine(s) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011080 increased macrophage apoptosis "greater incidence of cell death in macrophages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Fostm1Pa/Fostm1Pa
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Fostm2(Fosl1)Wag/Fostm2(Fosl1)Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fostm1Wag/Fostm2(Fosl1)Wag
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0030006 decreased retinal apoptosis "decrease in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Fostm1Wag/Fostm1Wag
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000052684 Jun / P05627 / jun proto-oncogene / P05412* / Jun proto-oncogene, AP-1 transcription factor subunit*  / complex / reaction
 ENSMUSG00000063358 Mapk1 / P63085 / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA. / P28482* / mitogen-activated protein kinase 1*  / reaction
 ENSMUSG00000063065 Mapk3 / Q63844 / Mitogen-activated protein kinase 3 / P27361*  / reaction
 ENSMUSG00000019768 Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*  / complex






 

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