ENSMUSG00000029135


Mus musculus

Features
Gene ID: ENSMUSG00000029135
  
Biological name :Fosl2
  
Synonyms : Fosl2 / Fos-related antigen 2 / P47930
  
Possible biological names infered from orthology : FOS like 2, AP-1 transcription factor subunit / P15408
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B1
Gene start: 32135801
Gene end: 32157842
  
Corresponding Affymetrix probe sets: 10520862 (MoGene1.0st)   1422931_at (Mouse Genome 430 2.0 Array)   1437247_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031017
NCBI entrez gene - 14284     See in Manteia.
MGI - MGI:102858
RefSeq - NM_008037
RefSeq Peptide - NP_032063
swissprot - P47930
Ensembl - ENSMUSG00000029135
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fosl2ENSDARG00000040623Danio rerio
 FOSL2ENSGALG00000010036Gallus gallus
 FOSL2ENSG00000075426Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fos / P01101 / Proto-onco c-Fos / P01100* / Fos proto-oncogene, AP-1 transcription factor subunit*ENSMUSG0000002125047
Fosl1 / P48755 / Fos-related antigen 1 / P15407* / FOS like 1, AP-1 transcription factor subunit*ENSMUSG0000002491241
Fosb / P13346 / Protein fosB / P53539* / FosB proto-oncogene, AP-1 transcription factor subunit*ENSMUSG0000000354539


Protein motifs (from Interpro)
Interpro ID Name
 IPR000837  AP-1 transcription factor
 IPR004827  Basic-leucine zipper domain
 IPR029814  Fos-related antigen 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003334 keratinocyte development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Igf1tm1Arge/Igf1+,Liftm1Stw/Lif+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1

 MP:0000131 abnormal long bone epiphysis morphology "the head of a developing long bone that is separated from the shaft by the epiphyseal plate" [J:61509]
Show

Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: involves: 129S1/Sv

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: involves: 129S1/Sv

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: involves: 129S1/Sv

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: involves: 129S1/Sv

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: involves: 129S1/Sv

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Col1a1tm2(tetO-Fosl2,-DsRed)Wag/Col1a1+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: involves: 129S1/Sv

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: involves: 129S1/Sv

Allelic Composition: Fosl2tm2.1Wag/Fosl2tm2.1Wag
Genetic Background: involves: 129P2/OlaHsd

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Igf1tm1Arge/Igf1+,Liftm1Stw/Lif+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: involves: 129S1/Sv

Allelic Composition: Fosl2tm2Wag/Fosl2tm2Wag,Tg(COL2A1-cre)1Wag/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Fosl2tm2.1Wag/Fosl2tm2.1Wag
Genetic Background: involves: 129P2/OlaHsd

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: involves: 129S1/Sv

 MP:0003409 decreased width of hypertrophic chondrocyte zone "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: involves: 129S1/Sv

Allelic Composition: Fosl2tm2Wag/Fosl2tm2Wag,Tg(COL2A1-cre)1Wag/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003419 delayed endochondral bone ossification "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
Show

Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: involves: 129S1/Sv

 MP:0004599 abnormal vertebral arch morphology "any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: involves: 129S1/Sv

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igf1tm1Arge/Igf1+,Liftm1Stw/Lif+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1

Allelic Composition: Fosl2tm2Wag/Fosl2tm2Wag,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igf1tm1Arge/Igf1+,Liftm1Stw/Lif+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1

 MP:0004986 abnormal osteoblast morphology "any structural anomaly of a bone-forming cell, which normally forms an osseous matrix (osteoid) in which it becomes enclosed as an osteocyte" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fosl2tm2Wag/Fosl2tm2Wag,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0004992 increased bone resorption "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igf1tm1Arge/Igf1+,Liftm1Stw/Lif+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Col1a1tm2(tetO-Fosl2,-DsRed)Wag/Col1a1+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0005039 hypoxia "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Igf1tm1Arge/Igf1+,Liftm1Stw/Lif+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1

 MP:0005225 abnormal vertebrae development "anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: involves: 129S1/Sv

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Col1a1tm2(tetO-Fosl2,-DsRed)Wag/Col1a1+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1tm2(tetO-Fosl2,-DsRed)Wag/Col1a1+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col1a1tm2(tetO-Fosl2,-DsRed)Wag/Col1a1+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CD-1

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igf1tm1Arge/Igf1+,Liftm1Stw/Lif+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1

Allelic Composition: Fosl2tm2Wag/Fosl2tm2Wag,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009285 increased gonadal fat pad weight "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fosl2tm2Wag/Fosl2tm2Wag,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fosl2tm2Wag/Fosl2tm2Wag,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fosl2tm2Wag/Fosl2tm2Wag,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0010876 decreased bone volume "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fosl2tm2Wag/Fosl2tm2Wag,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: involves: 129S1/Sv

Allelic Composition: Fosl2tm2Wag/Fosl2tm2Wag,Tg(COL2A1-cre)1Wag/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Fosl2tm2.1Wag/Fosl2tm2.1Wag
Genetic Background: involves: 129P2/OlaHsd

 MP:0011922 abnormal circulating osteocalcin level "aberrant concentration in the blood of this hormone secreted by osteoblasts which are found in bone and dentin" [MPD:Molly]
Show

Allelic Composition: Fosl2tm2Wag/Fosl2tm2Wag,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0014105 abnormal chondrocyte differentiation "any anomaly in the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte" [GO:0002062]
Show

Allelic Composition: Tpp1tm1Plob/Tpp1tm1Plob
Genetic Background: involves: 129S1/Sv

 MP:0020040 decreased bone ossification "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Fosl2tm2Wag/Fosl2tm2Wag,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0020137 decreased bone mineralization "decrease in the rate at which minerals are deposited into bone" []
Show

Allelic Composition: Fosl2tm2Wag/Fosl2tm2Wag,Tg(COL2A1-cre)1Wag/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr