ENSMUSG00000024912


Mus musculus

Features
Gene ID: ENSMUSG00000024912
  
Biological name :Fosl1
  
Synonyms : Fosl1 / Fos-related antigen 1 / P48755
  
Possible biological names infered from orthology : FOS like 1, AP-1 transcription factor subunit / P15407
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 5447703
Gene end: 5455945
  
Corresponding Affymetrix probe sets: 10460585 (MoGene1.0st)   1417487_at (Mouse Genome 430 2.0 Array)   1417488_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025850
NCBI entrez gene - 14283     See in Manteia.
MGI - MGI:107179
RefSeq - NM_010235
RefSeq Peptide - NP_034365
swissprot - P48755
swissprot - Q3UMK5
Ensembl - ENSMUSG00000024912
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fosl1aENSDARG00000015355Danio rerio
 FOSL1ENSG00000175592Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fosl2 / P47930 / Fos-related antigen 2 / P15408* / FOS like 2, AP-1 transcription factor subunit*ENSMUSG0000002913549
Fos / P01101 / Proto-onco c-Fos / P01100* / Fos proto-oncogene, AP-1 transcription factor subunit*ENSMUSG0000002125042
Fosb / P13346 / Protein fosB / P53539* / FosB proto-oncogene, AP-1 transcription factor subunit*ENSMUSG0000000354536


Protein motifs (from Interpro)
Interpro ID Name
 IPR000837  AP-1 transcription factor
 IPR004827  Basic-leucine zipper domain
 IPR029815  Fos-related antigen 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007296 vitellogenesis IMP
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007612 learning IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009629 response to gravity IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0031668 cellular response to extracellular stimulus IDA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045787 positive regulation of cell cycle IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051412 response to corticosterone IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0060674 placenta blood vessel development IMP
 biological_processGO:0061614 pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:2000144 positive regulation of DNA-templated transcription, initiation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Ctnnb1tm1Yy/Ctnnb1tm1Yy,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: FVB.Cg-Lepob/Chua

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: FVB.Cg-Lepob/Chua

 MP:0001711 abnormal placenta 
Show

Allelic Composition: Lepob/Lepob
Genetic Background: FVB.Cg-Lepob/Chua

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: FVB.Cg-Lepob/Chua

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: FVB.Cg-Lepob/Chua

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm1Yy/Ctnnb1tm1Yy,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: FVB.Cg-Lepob/Chua

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: FVB.Cg-Lepob/Chua

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm1Yy/Ctnnb1tm1Yy,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0004230 abnormal embryonic erythrocyte morphology "structural anomaly of the embryonic blood cells that carry oxygen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: FVB.Cg-Lepob/Chua

 MP:0004560 abnormal chorionic plate morphology "any structural anomaly of the portion of the chorion from which chorionic villi develop that establish a connection with the endometrium, giving rise to the fetal portion of the mature placenta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: FVB.Cg-Lepob/Chua

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctnnb1tm1Yy/Ctnnb1tm1Yy,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: FVB.Cg-Lepob/Chua

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ctnnb1tm1Yy/Ctnnb1tm1Yy,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: FVB.Cg-Lepob/Chua

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: FVB.Cg-Lepob/Chua

 MP:0011203 abnormal parietal yolk sac morphology "any structural anomaly of the tissue that consists of two cellular layers (parietal endoderm and trophoblast) separated by a relatively thick nonvascular basement membrane (Reichert s membrane), and acts as a protective layer to supports and facilitates transport of nutrients between the uterine tissue and the yolk sac cavity" [PMID:1150659, PMID:21123814]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: FVB.Cg-Lepob/Chua

 MP:0020515 abnormal visceral yolk sac endoderm morphology "any structural anomaly of the portion of the visceral yolk sac consisting of endoderm-derived cells that is responsible for absorption of nutrients" [https://discovery.lifemapsc.com/in-vivo-development/yolk-sac/yolk-sac-endoderm, PMID:20672346]
Show

Allelic Composition: Lepob/Lepob
Genetic Background: FVB.Cg-Lepob/Chua

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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