MP:0000160 | kyphosis | "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Nes-cre)1Wme/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
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MP:0000161 | scoliosis | "lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943] |
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Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Nes-cre)1Wme/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(COL2A1-cre)1Wag/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
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MP:0000255 | vasculature congestion | "obstruction of the normal flux of blood within the blood vessel network" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+ Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH
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MP:0000280 | thin ventricular wall | "decreased depth of the cardiac wall of the heart ventricles" [J:45302] |
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Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp,X/Tg(Tyr-HRAS)60Lc Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J * FVB
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MP:0000350 | abnormal cell proliferation | "anomalous growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Pou3f2tm1Rsd/Pou3f2tm1Rsd,Pou3f3tm1Rmc/Pou3f3tm1Rmc Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0 Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0000352 | decreased cell proliferation | "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Il2rgtm1Cgn/Y Genetic Background: involves: 129 * CB20
Allelic Composition: Juntm2.1Wag/Juntm2.1Wag Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0000596 | abnormal liver development | "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+ Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH
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MP:0000608 | dissociated hepatocytes | "disorganization of cohesive hepatocyte structure" [J:23170] |
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Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+ Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH
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MP:0000783 | abnormal forebrain morphology | "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+ Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH
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MP:0000852 | small cerebellum | "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524] |
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Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Juntm4Wag/Juntm4Wag,Tg(En2-cre)22Alj/0 Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Juntm2.1Wag/Juntm4Wag,Tg(En2-cre)22Alj/0 Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
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MP:0000877 | abnormal Purkinje cell | "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Juntm4Wag/Juntm4Wag,Tg(En2-cre)22Alj/0 Genetic Background: involves: 129P2/OlaHsd
Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Juntm2.1Wag/Juntm4Wag,Tg(En2-cre)22Alj/0 Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
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MP:0000914 | exencephaly | "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
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Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0001175 | abnormal lung morphology | "malformed organ of respiration" [J:35802] |
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Allelic Composition: Ephb2tm1Paw/Ephb2+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0001193 | psoriasis | "chronic skin lesions characterized by inflammation and silvery-scaly patches" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
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MP:0001219 | thickened epidermis | "increase in the width of the epidermal cell layer in the skin" [J:65146] |
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Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
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MP:0001242 | hyperkeratosis | "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133] |
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Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
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MP:0001258 | decreased body length | "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator] |
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Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Nes-cre)1Wme/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Juntm2.1Wag/Juntm2.1Wag Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
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MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Aldh1a2tm1Gdu/Aldh1a2tm1Gdu Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Nes-cre)1Wme/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Alb1-cre)7Gsc/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N
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MP:0001297 | microphthalmia | "reduced average size of the eyes" [J:18048] |
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Allelic Composition: Juntm1Rsjo/Juntm1Rsjo,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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MP:0001302 | eyelids open at birth | "widely open eyes instead of closed at perinatal stage" [J:51966] |
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Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Nes-cre)1Wme/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Allelic Composition: Juntm5.1(Junb)Wag/Juntm5.1(Junb)Wag Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0 Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Juntm1Rsjo/Juntm1Rsjo,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0001313 | increased incidence of corneal inflammation | "greater than average and persistent occurrence of corneal irritation" [J:4606] |
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Allelic Composition: Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag Genetic Background: 129/Sv
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MP:0001575 | cyanosis | "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159] |
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Allelic Composition: Juntm5.1(Junb)Wag/Juntm5.1(Junb)Wag Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0001614 | abnormal vasculature | "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
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MP:0001654 | hepatic necrosis | "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+ Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH
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MP:0001785 | edema | "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065] |
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Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+ Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH
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MP:0001792 | impaired wound healing | "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag Genetic Background: 129/Sv
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MP:0001846 | increased inflammatory response | "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
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MP:0001861 | lung inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Ephb2tm1Paw/Ephb2+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0001958 | emphysema | "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629] |
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Allelic Composition: Ephb2tm1Paw/Ephb2+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0002060 | abnormal skin morphology | "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777] |
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Allelic Composition: Tet1Gt(RRG140)Byg/Tet1Gt(RRG140)Byg Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0 Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0002151 | abnormal neural tube morphology/development | "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pdlim5tm1.1Chen/Pdlim5tm1.1Chen Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss
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MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Juntm2.1Wag/Juntm2.1Wag Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
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MP:0002633 | persistent truncus arteriosis | "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Juntm5.1(Junb)Wag/Juntm5.1(Junb)Wag Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Juntm1Wag/Juntm1Wag Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0002655 | abnormal keratinocyte morphology | "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Juntm1Rsjo/Juntm1Rsjo,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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MP:0002658 | abnormal liver regeneration | "deviation from the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [il:Ira Lu , Mouse Genome Informatics Curator] |
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Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Alb1-cre)7Gsc/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Mx1-cre)1Cgn/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
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MP:0002887 | resistance to pharmacologically induced seizures | "ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:77284] |
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Allelic Composition: Juntm2.1Wag/Juntm2.1Wag Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
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MP:0002908 | delayed wound healing | "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037] |
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Allelic Composition: Juntm1Rsjo/Juntm1Rsjo,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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MP:0002929 | abnormal bile duct development | "incomplete or aberrant differentiation of the channels that secrete bile from the liver to the gall bladder and intestines" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission] |
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Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+ Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH
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MP:0002993 | arthritis | "joint inflammation, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
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MP:0003202 | abnormal neuron apoptosis | "change in the timing or the number of neurons undergoing programmed cell death" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Tg(Nes-cre)1Kln/0 Genetic Background: involves: C57BL/6 * SJL
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MP:0003204 | decreased neuron apoptosis | "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission] |
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Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129P2/OlaHsd * ICR
Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
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MP:0003402 | decreased liver weight | "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Alb1-cre)7Gsc/0 Genetic Background: involves: 129P2/OlaHsd * FVB/N
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MP:0003427 | parakeratosis | "abnormal retention of the nuclei of the keratinocytes in the stratum corneum of the epidermis" [smb:Susan M Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
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MP:0003453 | abnormal keratinocyte physiology | "atypical function of the cells of the epidermis that produce keratin" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94860] |
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Allelic Composition: Juntm1Rsjo/Juntm1Rsjo,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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MP:0003674 | oxidative stress | "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Il2rgtm1Cgn/Y Genetic Background: involves: 129 * CB20
Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0003795 | abnormal bone structure | |
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Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
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MP:0003887 | increased hepatocyte apoptosis | "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Juntm1Wag/Juntm1Wag Genetic Background: involves: 129S2/SvPas * C57BL/6
Allelic Composition: Juntm1Wag/Juntm1Wag Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)
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MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
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MP:0004001 | decreased hepatocyte proliferation | "reduced growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Juntm1Wag/Juntm1Wag Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0004158 | right aortic arch | "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Juntm1Wag/Juntm1Wag Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0004613 | fusion of vertebral arches | "improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Nes-cre)1Wme/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
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MP:0004624 | abnormal thoracic cage | "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(COL2A1-cre)1Wag/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
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MP:0004947 | skin inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
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MP:0006104 | abnormal tectum morphology | "any structural alterations or malfunction of the rostral part of the midbrain roof" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, J:65762] |
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Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Tg(Nes-cre)1Kln/0 Genetic Background: involves: C57BL/6 * SJL
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MP:0008008 | early cellular replicative senescence | "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
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MP:0008236 | decreased susceptibility to neuronal excitotoxicity | "less than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Juntm2.1Wag/Juntm2.1Wag Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
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MP:0008411 | decreased cellular sensitivity to ultraviolet irradiation | "reduced incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Juntm2.1Wag/Juntm2.1Wag Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
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MP:0008713 | abnormal cytokine level | "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ephb2tm1Paw/Ephb2+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0008752 | abnormal tumor necrosis factor level | "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800] |
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Allelic Composition: Ephb2tm1Paw/Ephb2+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0009264 | failure of eyelid fusion | "the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye do not fuse together during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Juntm5.1(Junb)Wag/Juntm5.1(Junb)Wag Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Juntm1Rsjo/Juntm1Rsjo,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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MP:0009267 | abnormal cerebellum fissure morphology | "any structural anomaly of the deep furrows which divide the lobules of the cerebellum, including the postcentral, primary and secondary furrows" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Juntm4Wag/Juntm4Wag,Tg(En2-cre)22Alj/0 Genetic Background: involves: 129P2/OlaHsd
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MP:0009395 | persistence of primitive erythrocytes | "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Juntm1Wag/Juntm1Wag Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)
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MP:0009584 | decreased keratinocyte proliferation | "reduction in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Juntm1Rsjo/Juntm1Rsjo,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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MP:0009651 | abnormal eyelid development | "aberrant formation of the skin folds covering the front of the eyeball" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Juntm1Rsjo/Juntm1Rsjo,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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MP:0009859 | eye opacity | "changes in the eye grossly observed as a milky or cloudy appearance that may be progressive and persistent throughout life" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Juntm1Rsjo/Juntm1Rsjo,Tg(KRT14-cre)8Brn/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N
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MP:0010402 | ventricular septal defect | "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540] |
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Allelic Composition: Juntm5.1(Junb)Wag/Juntm5.1(Junb)Wag Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Juntm1Wag/Juntm1Wag Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0010454 | abnormal truncus arteriosis septation | "anomaly in the process of dividing the common arterial trunk arising out of both heart ventricles to divide into the aorta and pulmonary artery during development" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Juntm5.1(Junb)Wag/Juntm5.1(Junb)Wag Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0010899 | abnormal pulmonary alveolar system morphology | |
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Allelic Composition: Ephb2tm1Paw/Ephb2+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0010901 | abnormal pulmonary alveolar parenchyma morphology | "any structural anomaly of the distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ephb2tm1Paw/Ephb2+ Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0010971 | abnormal periosteum morphology | "any structural anomaly of the thick fibrous membrane that closely invests the entire surface of a bone except the articular cartilage at synovial joints" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL
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MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Juntm5.1(Junb)Wag/Juntm5.1(Junb)Wag Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Nes-cre)1Wme/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0 Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0011087 | complete neonatal lethality | "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0011088 | partial neonatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Juntm5.1(Junb)Wag/Juntm5.1(Junb)Wag Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0011090 | partial perinatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Juntm5.1(Junb)Wag/Juntm5.1(Junb)Wag Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0 Genetic Background: involves: 129S2/SvPas * C57BL/6
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MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Cremtm1Saco/Cremtm1Saco Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
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MP:0011099 | complete lethality throughout fetal growth and development | "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Juntm1Wag/Juntm1Wag Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)
Allelic Composition: Juntm1Wag/Juntm5.1(Junb)Wag Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
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MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Nes-cre)1Wme/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA
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MP:0011108 | partial embryonic lethality during organogenesis | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Juntm1Wag/Juntm1Wag Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)
Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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MP:0011704 | decreased fibroblast proliferation | "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith] |
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Allelic Composition: Cremtm1Saco/Cremtm1Saco Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
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MP:0012752 | abnormal cardiac neural crest cell migration | "any anomaly in the migratory path of cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs which originate from the lower hindbrain between the otic placode and third somite and migrate to the circumpharyngeal ridge (an arc-shape ridge located dorsal to the forming caudal pharyngeal arches) and then into the 3rd, 4th and 6th pharyngeal arches and the cardiac outflow tract (OFT); cardiac NCCs undergo migration away from the neural tube by following a dorsolateral path under the ectoderm, leading them to the pharyngeal arches; after pausing, they resume migration under the pharyngeal endoderm and, along the aortic arch arteries, populate the cardiac OFT where they contribute the aorticopulmonary septum, and ultimately colonize the heart to form the ventricular septum and cardiac ganglia" [MGI:anna] |
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Allelic Composition: Juntm1Wag/Juntm1Wag Genetic Background: involves: 129S2/SvPas * C57BL/6
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