ENSMUSG00000052684


Mus musculus

Features
Gene ID: ENSMUSG00000052684
  
Biological name :Jun
  
Synonyms : Jun / jun proto-oncogene / P05627
  
Possible biological names infered from orthology : Jun proto-oncogene, AP-1 transcription factor subunit / P05412
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C5
Gene start: 95049034
Gene end: 95052222
  
Corresponding Affymetrix probe sets: 10514466 (MoGene1.0st)   1417409_at (Mouse Genome 430 2.0 Array)   1448694_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102711
NCBI entrez gene - 16476     See in Manteia.
MGI - MGI:96646
RefSeq - NM_010591
RefSeq Peptide - NP_034721
swissprot - P05627
swissprot - Q52L79
Ensembl - ENSMUSG00000052684
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 junENSDARG00000043531Danio rerio
 JUNENSGALG00000010870Gallus gallus
 JUNENSG00000177606Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Jund / P15066 / Transcription factor jun-D / P17535* / JunD proto-oncogene, AP-1 transcription factor subunit*ENSMUSG0000007107651
Junb / P09450 / Transcription factor jun-B / P17275* / JunB proto-oncogene, AP-1 transcription factor subunit*ENSMUSG0000005283748


Protein motifs (from Interpro)
Interpro ID Name
 IPR002112  Transcription factor Jun
 IPR004827  Basic-leucine zipper domain
 IPR005643  Jun-like transcription factor
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR015558  Transcription Factor c-Jun/v-Jun


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001774 microglial cell activation IMP
 biological_processGO:0001836 release of cytochrome c from mitochondria IEA
 biological_processGO:0001889 liver development IMP
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IMP
 biological_processGO:0003151 outflow tract morphogenesis IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IMP
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007265 Ras protein signal transduction IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007612 learning IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IGI
 biological_processGO:0009314 response to radiation IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009987 cellular process IMP
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010634 positive regulation of epithelial cell migration IMP
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0030224 monocyte differentiation IMP
 biological_processGO:0031103 axon regeneration IMP
 biological_processGO:0031953 negative regulation of protein autophosphorylation IMP
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0034614 cellular response to reactive oxygen species IEA
 biological_processGO:0035026 leading edge cell differentiation IMP
 biological_processGO:0035994 response to muscle stretch IDA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043392 negative regulation of DNA binding IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0043922 negative regulation by host of viral transcription IEA
 biological_processGO:0043923 positive regulation by host of viral transcription IEA
 biological_processGO:0045597 positive regulation of cell differentiation IBA
 biological_processGO:0045657 positive regulation of monocyte differentiation IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IGI
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0051365 cellular response to potassium ion starvation IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0051726 regulation of cell cycle IMP
 biological_processGO:0051899 membrane depolarization IEA
 biological_processGO:0060395 SMAD protein signal transduction IEA
 biological_processGO:0061029 eyelid development in camera-type eye IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0071276 cellular response to cadmium ion IEA
 biological_processGO:0071277 cellular response to calcium ion IDA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:1990441 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IEA
 biological_processGO:2000144 positive regulation of DNA-templated transcription, initiation IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IPI
 cellular_componentGO:0005719 nuclear euchromatin IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0017053 transcriptional repressor complex IPI
 cellular_componentGO:0035976 transcription factor AP-1 complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0033613 activating transcription factor binding IEA
 molecular_functionGO:0035497 cAMP response element binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0070412 R-SMAD binding IEA
 molecular_functionGO:0071837 HMG box domain binding IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
Activation of the AP-1 family of transcription factors
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000161 scoliosis "lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]
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Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(COL2A1-cre)1Wag/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000255 vasculature congestion "obstruction of the normal flux of blood within the blood vessel network" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Cdkn2atm2.1Rdp/Cdkn2atm2.1Rdp,X/Tg(Tyr-HRAS)60Lc
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J * FVB

 MP:0000350 abnormal cell proliferation "anomalous growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pou3f2tm1Rsd/Pou3f2tm1Rsd,Pou3f3tm1Rmc/Pou3f3tm1Rmc
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il2rgtm1Cgn/Y
Genetic Background: involves: 129 * CB20

Allelic Composition: Juntm2.1Wag/Juntm2.1Wag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000596 abnormal liver development "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0000608 dissociated hepatocytes "disorganization of cohesive hepatocyte structure" [J:23170]
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Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Juntm4Wag/Juntm4Wag,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Juntm2.1Wag/Juntm4Wag,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Juntm4Wag/Juntm4Wag,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Juntm2.1Wag/Juntm4Wag,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Ephb2tm1Paw/Ephb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001193 psoriasis "chronic skin lesions characterized by inflammation and silvery-scaly patches" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Juntm2.1Wag/Juntm2.1Wag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Aldh1a2tm1Gdu/Aldh1a2tm1Gdu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Juntm1Rsjo/Juntm1Rsjo,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Juntm5.1(Junb)Wag/Juntm5.1(Junb)Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Juntm1Rsjo/Juntm1Rsjo,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001313 increased incidence of corneal inflammation "greater than average and persistent occurrence of corneal irritation" [J:4606]
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Allelic Composition: Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag
Genetic Background: 129/Sv

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Juntm5.1(Junb)Wag/Juntm5.1(Junb)Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0001792 impaired wound healing "reduced ability or inability to self-repair and close wounds" [J:65302, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egfrtm2(EGFR)Wag/Egfrtm2(EGFR)Wag
Genetic Background: 129/Sv

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ephb2tm1Paw/Ephb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
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Allelic Composition: Ephb2tm1Paw/Ephb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Tet1Gt(RRG140)Byg/Tet1Gt(RRG140)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdlim5tm1.1Chen/Pdlim5tm1.1Chen
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Juntm2.1Wag/Juntm2.1Wag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002633 persistent truncus arteriosis "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Juntm5.1(Junb)Wag/Juntm5.1(Junb)Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Juntm1Wag/Juntm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Juntm1Rsjo/Juntm1Rsjo,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002658 abnormal liver regeneration "deviation from the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002887 resistance to pharmacologically induced seizures "ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:77284]
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Allelic Composition: Juntm2.1Wag/Juntm2.1Wag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Juntm1Rsjo/Juntm1Rsjo,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0002929 abnormal bile duct development "incomplete or aberrant differentiation of the channels that secrete bile from the liver to the gall bladder and intestines" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: GnasOedsml/Gnas+,Nespastm1Jop/Nespas+
Genetic Background: involves: 101/H * 129S/SvEv * C3H/HeH

 MP:0002993 arthritis "joint inflammation, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003202 abnormal neuron apoptosis "change in the timing or the number of neurons undergoing programmed cell death" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Fgfr1tm1Upir/Fgfr1tm1Upir,Foxg1tm1(cre)Skm/Foxg1+
Genetic Background: involves: 129P2/OlaHsd * ICR

Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003427 parakeratosis "abnormal retention of the nuclei of the keratinocytes in the stratum corneum of the epidermis" [smb:Susan M Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003453 abnormal keratinocyte physiology "atypical function of the cells of the epidermis that produce keratin" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94860]
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Allelic Composition: Juntm1Rsjo/Juntm1Rsjo,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Il2rgtm1Cgn/Y
Genetic Background: involves: 129 * CB20

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003795 abnormal bone structure 
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Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Juntm1Wag/Juntm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Juntm1Wag/Juntm1Wag
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0004001 decreased hepatocyte proliferation "reduced growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Juntm1Wag/Juntm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004158 right aortic arch "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Juntm1Wag/Juntm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004613 fusion of vertebral arches "improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0004624 abnormal thoracic cage "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(COL2A1-cre)1Wag/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0006104 abnormal tectum morphology "any structural alterations or malfunction of the rostral part of the midbrain roof" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator, J:65762]
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Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0008236 decreased susceptibility to neuronal excitotoxicity "less than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Juntm2.1Wag/Juntm2.1Wag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008411 decreased cellular sensitivity to ultraviolet irradiation "reduced incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Juntm2.1Wag/Juntm2.1Wag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ephb2tm1Paw/Ephb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
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Allelic Composition: Ephb2tm1Paw/Ephb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009264 failure of eyelid fusion "the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye do not fuse together during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Juntm5.1(Junb)Wag/Juntm5.1(Junb)Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Juntm1Rsjo/Juntm1Rsjo,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0009267 abnormal cerebellum fissure morphology "any structural anomaly of the deep furrows which divide the lobules of the cerebellum, including the postcentral, primary and secondary furrows" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Fbxw7tm1.1Axbe/Fbxw7tm1.1Axbe,Juntm4Wag/Juntm4Wag,Tg(En2-cre)22Alj/0
Genetic Background: involves: 129P2/OlaHsd

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Juntm1Wag/Juntm1Wag
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

 MP:0009584 decreased keratinocyte proliferation "reduction in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Juntm1Rsjo/Juntm1Rsjo,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0009651 abnormal eyelid development "aberrant formation of the skin folds covering the front of the eyeball" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Juntm1Rsjo/Juntm1Rsjo,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0009859 eye opacity "changes in the eye grossly observed as a milky or cloudy appearance that may be progressive and persistent throughout life" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Juntm1Rsjo/Juntm1Rsjo,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Juntm5.1(Junb)Wag/Juntm5.1(Junb)Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Juntm1Wag/Juntm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0010454 abnormal truncus arteriosis septation "anomaly in the process of dividing the common arterial trunk arising out of both heart ventricles to divide into the aorta and pulmonary artery during development" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Juntm5.1(Junb)Wag/Juntm5.1(Junb)Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010899 abnormal pulmonary alveolar system morphology 
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Allelic Composition: Ephb2tm1Paw/Ephb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010901 abnormal pulmonary alveolar parenchyma morphology "any structural anomaly of the distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ephb2tm1Paw/Ephb2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010971 abnormal periosteum morphology "any structural anomaly of the thick fibrous membrane that closely invests the entire surface of a bone except the articular cartilage at synovial joints" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Juntm5.1(Junb)Wag/Juntm5.1(Junb)Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Juntm5.1(Junb)Wag/Juntm5.1(Junb)Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Juntm5.1(Junb)Wag/Juntm5.1(Junb)Wag
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Juntm1Wag/Juntm1Wag
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

Allelic Composition: Juntm1Wag/Juntm5.1(Junb)Wag
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Juntm4Wag/Juntm4Wag,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Juntm1Wag/Juntm1Wag
Genetic Background: either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Cremtm1Saco/Cremtm1Saco
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0012752 abnormal cardiac neural crest cell migration "any anomaly in the migratory path of cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs which originate from the lower hindbrain between the otic placode and third somite and migrate to the circumpharyngeal ridge (an arc-shape ridge located dorsal to the forming caudal pharyngeal arches) and then into the 3rd, 4th and 6th pharyngeal arches and the cardiac outflow tract (OFT); cardiac NCCs undergo migration away from the neural tube by following a dorsolateral path under the ectoderm, leading them to the pharyngeal arches; after pausing, they resume migration under the pharyngeal endoderm and, along the aortic arch arteries, populate the cardiac OFT where they contribute the aorticopulmonary septum, and ultimately colonize the heart to form the ventricular septum and cardiac ganglia" [MGI:anna]
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Allelic Composition: Juntm1Wag/Juntm1Wag
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020366 Mapk9 / Q9WTU6 / Mitogen-activated protein kinase 9 / P45984*  / reaction
 ENSMUSG00000021936 Mapk8 / Q91Y86 / Mitogen-activated protein kinase 8 / P45983*  / reaction
 ENSMUSG00000021250 Fos / P01101 / Proto-onco c-Fos / P01100* / Fos proto-oncogene, AP-1 transcription factor subunit*  / complex / reaction
 ENSMUSG00000028969 Cdk5 / P49615 / Cyclin-dependent-like kinase 5 / Q00535* / cyclin dependent kinase 5*  / reaction
 ENSMUSG00000019768 Esr1 / P19785 / Estrogen receptor / P03372* / estrogen receptor 1*  / complex
 ENSMUSG00000048895 Cdk5r1 / P61809 / Cyclin-dependent kinase 5 activator 1 Cyclin-dependent kinase 5 activator 1, p35 Cyclin-dependent kinase 5 activator 1, p25 / Q15078* / cyclin dependent kinase 5 regulator...  / reaction
 ENSMUSG00000027104 Atf2 / P16951 / Cyclic AMP-dependent transcription factor ATF-2 / P15336* / activating transcription factor 2*  / reaction / complex
 ENSMUSG00000074622 Mafb / P54841 / Transcription factor MafB / Q9Y5Q3* / MAF bZIP transcription factor B*  / complex






 

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