ENSMUSG00000071076


Mus musculus

Features
Gene ID: ENSMUSG00000071076
  
Biological name :Jund
  
Synonyms : Jund / P15066 / Transcription factor jun-D
  
Possible biological names infered from orthology : JunD proto-oncogene, AP-1 transcription factor subunit / P17535
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B3.3
Gene start: 70698949
Gene end: 70700616
  
Corresponding Affymetrix probe sets: 10572456 (MoGene1.0st)   1440265_at (Mouse Genome 430 2.0 Array)   1449117_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000092901
NCBI entrez gene - 16478     See in Manteia.
MGI - MGI:96648
RefSeq - NM_010592
RefSeq - NM_001286944
RefSeq Peptide - NP_001273873
RefSeq Peptide - NP_034722
swissprot - P15066
Ensembl - ENSMUSG00000071076
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 jundENSDARG00000067850Danio rerio
 JUNDENSGALG00000043641Gallus gallus
 JUNDENSG00000130522Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Jun / P05627 / jun proto-oncogene / P05412* / Jun proto-oncogene, AP-1 transcription factor subunit*ENSMUSG0000005268450
Junb / P09450 / Transcription factor jun-B / P17275* / JunB proto-oncogene, AP-1 transcription factor subunit*ENSMUSG0000005283741


Protein motifs (from Interpro)
Interpro ID Name
 IPR002112  Transcription factor Jun
 IPR004827  Basic-leucine zipper domain
 IPR005643  Jun-like transcription factor
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR029823  Transcription factor JunD


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0002076 osteoblast development IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0009314 response to radiation IBA
 biological_processGO:0009416 response to light stimulus IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0010941 regulation of cell death IBA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:0034097 response to cytokine IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042493 response to drug IBA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051591 response to cAMP IBA
 biological_processGO:0051726 regulation of cell cycle IBA
 biological_processGO:0071277 cellular response to calcium ion IDA
 cellular_componentGO:0000790 nuclear chromatin IBA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005667 transcription factor complex IBA
 cellular_componentGO:0032993 protein-DNA complex IEA
 cellular_componentGO:0035976 transcription factor AP-1 complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0016922 nuclear receptor binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Wnt1tm1Brd/Wnt1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Hsf4tm1Anak/Hsf4tm1Anak
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Hsf4tm1Anak/Hsf4tm1Anak
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Col1a1tm4(tetO-Jun/Fosl2)Wag/Col1a1+,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Wnt1tm1Brd/Wnt1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Hsf4tm1Anak/Hsf4tm1Anak
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Wnt1tm1Brd/Wnt1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Hsf4tm1Anak/Hsf4tm1Anak
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Hsf4tm1Anak/Hsf4tm1Anak
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Wnt1tm1Brd/Wnt1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Hsf4tm1Anak/Hsf4tm1Anak
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col1a1tm4(tetO-Jun/Fosl2)Wag/Col1a1+,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Hsf4tm1Anak/Hsf4tm1Anak
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Hsf4tm1Anak/Hsf4tm1Anak
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Hsf4tm1Anak/Hsf4tm1Anak
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0002790 decreased circulating follicle stimulating hormone level "less than expected blood concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Hsf4tm1Anak/Hsf4tm1Anak
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Wnt1tm1Brd/Wnt1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Hsf4tm1Anak/Hsf4tm1Anak
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1tm4(tetO-Jun/Fosl2)Wag/Col1a1+,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004486 decreased response of heart to induced stress "decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wnt1tm1Brd/Wnt1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005120 decreased circulating growth hormone level "less than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Hsf4tm1Anak/Hsf4tm1Anak
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0005136 decreased growth hormone level "less than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Hsf4tm1Anak/Hsf4tm1Anak
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Col1a1tm4(tetO-Jun/Fosl2)Wag/Col1a1+,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Wnt1tm1Brd/Wnt1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005324 ascites "accumulation or retention of fluid within the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Wnt1tm1Brd/Wnt1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Hsf4tm1Anak/Hsf4tm1Anak
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Hsf4tm1Anak/Hsf4tm1Anak
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col1a1tm4(tetO-Jun/Fosl2)Wag/Col1a1+,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Hsf4tm1Anak/Hsf4tm1Anak
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Wnt1tm1Brd/Wnt1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Wnt1tm1Brd/Wnt1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Wnt1tm1Brd/Wnt1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0008410 increased cellular sensitivity to ultraviolet irradiation "greater incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Hsf4tm1Anak/Hsf4tm1Anak
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Hsf4tm1Anak/Hsf4tm1Anak
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0008907 decreased total fat pad weight "less than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm4(tetO-Jun/Fosl2)Wag/Col1a1+,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col1a1tm4(tetO-Jun/Fosl2)Wag/Col1a1+,Tg(Cebpb-tTA)5Bjd/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * NMRI

 MP:0010017 visceral vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the internal organs enclosed within the cavity of the body, such as the thoracic, abdominal, endocrine, and pelvic organs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wnt1tm1Brd/Wnt1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0010018 lung vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wnt1tm1Brd/Wnt1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0010019 liver vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Wnt1tm1Brd/Wnt1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Wnt1tm1Brd/Wnt1tm1Brd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Hsf1tm1Anak/Hsf1tm1Anak,Hsf4tm1Anak/Hsf4tm1Anak
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Juntm6.1(Jund)Wag/Juntm6.1(Jund)Wag,Jundtm1Mya/Jundtm1Mya
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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