ENSMUSG00000052837


Mus musculus

Features
Gene ID: ENSMUSG00000052837
  
Biological name :Junb
  
Synonyms : Junb / P09450 / Transcription factor jun-B
  
Possible biological names infered from orthology : JunB proto-oncogene, AP-1 transcription factor subunit / P17275
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: C3
Gene start: 84974484
Gene end: 84978718
  
Corresponding Affymetrix probe sets: 10580282 (MoGene1.0st)   1415899_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000064680
NCBI entrez gene - 16477     See in Manteia.
MGI - MGI:96647
RefSeq - NM_008416
RefSeq Peptide - NP_032442
swissprot - P09450
swissprot - Q569U6
Ensembl - ENSMUSG00000052837
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 junbaENSDARG00000074378Danio rerio
 junbbENSDARG00000104773Danio rerio
 ENSGALG00000041930Gallus gallus
 JUNBENSG00000171223Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Jun / P05627 / jun proto-oncogene / P05412* / Jun proto-oncogene, AP-1 transcription factor subunit*ENSMUSG0000005268447
Jund / P15066 / Transcription factor jun-D / P17535* / JunD proto-oncogene, AP-1 transcription factor subunit*ENSMUSG0000007107640


Protein motifs (from Interpro)
Interpro ID Name
 IPR002112  Transcription factor Jun
 IPR004827  Basic-leucine zipper domain
 IPR005643  Jun-like transcription factor
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR029822  Transcription factor JunB


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0001649 osteoblast differentiation IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001829 trophectodermal cell differentiation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0009314 response to radiation IBA
 biological_processGO:0009612 response to mechanical stimulus IBA
 biological_processGO:0009987 cellular process IDA
 biological_processGO:0010941 regulation of cell death IBA
 biological_processGO:0030316 osteoclast differentiation IMP
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:0033687 osteoblast proliferation IMP
 biological_processGO:0034097 response to cytokine IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042493 response to drug IBA
 biological_processGO:0045597 positive regulation of cell differentiation IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046697 decidualization IMP
 biological_processGO:0051591 response to cAMP IBA
 biological_processGO:0051726 regulation of cell cycle IDA
 biological_processGO:0060136 embryonic process involved in female pregnancy IMP
 biological_processGO:0060716 labyrinthine layer blood vessel development IMP
 biological_processGO:0071277 cellular response to calcium ion IDA
 cellular_componentGO:0000790 nuclear chromatin IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005667 transcription factor complex IBA
 cellular_componentGO:0035976 transcription factor AP-1 complex IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
Show

Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0001193 psoriasis "chronic skin lesions characterized by inflammation and silvery-scaly patches" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
Show

Allelic Composition: Col7a1tm1Uit/Col7a1tm1Uit,Tg(KRT14-COL7A1*)1Shzu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

 MP:0001200 thick skin "greater depth of skin " [J:47225]
Show

Allelic Composition: Col7a1tm1Uit/Col7a1tm1Uit,Tg(KRT14-COL7A1*)1Shzu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

Allelic Composition: Il6tm1Kopf/Il6tm1Kopf,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6

 MP:0001209 spontaneous skin ulceration "unpredictable appearance of skin lesions, usually with inflammation" [J:65302]
Show

Allelic Composition: Col7a1tm1Uit/Col7a1tm1Uit,Tg(KRT14-COL7A1*)1Shzu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Il6tm1Kopf/Il6tm1Kopf,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6

 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: Il6tm1Kopf/Il6tm1Kopf,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6

Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001533 abnormal skeleton physiology "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col7a1tm1Uit/Col7a1tm1Uit,Tg(KRT14-COL7A1*)1Shzu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Tet1Gt(RRG140)Byg/Tet1Gt(RRG140)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col7a1tm1Uit/Col7a1tm1Uit,Tg(KRT14-COL7A1*)1Shzu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il6tm1Kopf/Il6tm1Kopf,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col7a1tm1Uit/Col7a1tm1Uit,Tg(KRT14-COL7A1*)1Shzu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col7a1tm1Uit/Col7a1tm1Uit,Tg(KRT14-COL7A1*)1Shzu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Col7a1tm1Uit/Col7a1tm1Uit,Tg(KRT14-COL7A1*)1Shzu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col7a1tm1Uit/Col7a1tm1Uit,Tg(KRT14-COL7A1*)1Shzu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

 MP:0002993 arthritis "joint inflammation, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003427 parakeratosis "abnormal retention of the nuclei of the keratinocytes in the stratum corneum of the epidermis" [smb:Susan M Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0004796 increased anti-histone antibody level "elevated level of antibodies to histones present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col7a1tm1Uit/Col7a1tm1Uit,Tg(KRT14-COL7A1*)1Shzu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col7a1tm1Uit/Col7a1tm1Uit,Tg(KRT14-COL7A1*)1Shzu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

Allelic Composition: Csf3tm1Ard/Csf3tm1Ard,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C3H * C57BL/6

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il6tm1Kopf/Il6tm1Kopf,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6

Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0004970 kidney atrophy "wasting of the kidney due to injury or disease, resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col7a1tm1Uit/Col7a1tm1Uit,Tg(KRT14-COL7A1*)1Shzu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0004989 decreased osteoblast cell number "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0004991 decreased bone strength "reduced ability of bone to endure the application of force without yielding or breaking" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0004993 decreased bone resorption "reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0005481 chronic myelocytic leukemia "a heterogeneous group of myeloproliferative disorders that may evolve into acute leukemia in late stages " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col7a1tm1Uit/Col7a1tm1Uit,Tg(KRT14-COL7A1*)1Shzu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

 MP:0008140 podocyte foot process effacement "thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Col7a1tm1Uit/Col7a1tm1Uit,Tg(KRT14-COL7A1*)1Shzu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
Show

Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

Allelic Composition: Junbtm3Wag/Junbtm3Wag,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ednratm1Ywa/Ednratm1Ywa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Col7a1tm1Uit/Col7a1tm1Uit,Tg(KRT14-COL7A1*)1Shzu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Col7a1tm1Uit/Col7a1tm1Uit,Tg(KRT14-COL7A1*)1Shzu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

 MP:0010971 abnormal periosteum morphology "any structural anomaly of the thick fibrous membrane that closely invests the entire surface of a bone except the articular cartilage at synovial joints" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Juntm4Wag/Juntm4Wag,Junbtm3Wag/Junbtm3Wag,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

 MP:0011159 abnormal epidermal-dermal junction morphology "any structural anomaly of the multi-layer basement membrane between the dermis and epidermis that serves to adhere the dermis and epidermis, provide mechanical support for the epidermis, and forms a barrier to cells and large molecules across the junction" [PMID:1097542]
Show

Allelic Composition: Col7a1tm1Uit/Col7a1tm1Uit,Tg(KRT14-COL7A1*)1Shzu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

 MP:0011320 abnormal glomerular capillary morphology "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith]
Show

Allelic Composition: Col7a1tm1Uit/Col7a1tm1Uit,Tg(KRT14-COL7A1*)1Shzu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

 MP:0011405 tubulointerstitial nephritis "diffuse or local inflammation and edema of the interstitial tissue of the kidney, including the renal tubules; usually secondary to drug sensitization, systemic infection, graft rejection, or autoimmune disease" [MGI:anna]
Show

Allelic Composition: Col7a1tm1Uit/Col7a1tm1Uit,Tg(KRT14-COL7A1*)1Shzu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

 MP:0011409 increased renal glomerulus basement membrane thickness "increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]
Show

Allelic Composition: Col7a1tm1Uit/Col7a1tm1Uit,Tg(KRT14-COL7A1*)1Shzu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

 MP:0011427 mesangial cell hyperplasia "increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]
Show

Allelic Composition: Col7a1tm1Uit/Col7a1tm1Uit,Tg(KRT14-COL7A1*)1Shzu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

 MP:0011567 increased renal glomerulus lobularity "distortion of the renal glomerular architecture usually accompanied by increased mesangial cell proliferation and following crowding of the proliferated cells towards the axis of the capillary loops and peripheral recanalization, giving the glomerular tuft a lobular or hypersegmented appearance" [MGI:anna]
Show

Allelic Composition: Col7a1tm1Uit/Col7a1tm1Uit,Tg(KRT14-COL7A1*)1Shzu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
Show

Allelic Composition: Col7a1tm1Uit/Col7a1tm1Uit,Tg(KRT14-COL7A1*)1Shzu/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr