MP:0000026 | abnormal inner ear morphology | "malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776] |
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Allelic Composition: Dlx5tm1Jlr/Dlx5+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0000035 | abnormal membranous labyrinth | "malformations in the complex arrangement of communicating canaliculi and sacs suspended within the cavity of the bony labyrinth of the inner ear" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23837] |
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Allelic Composition: Dlx5tm1Jlr/Dlx5+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0000041 | absent endolymphatic duct | "missing small membranous canal of the inner ear; connecting membranous labyrinth with the endolymphatic sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776] |
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Allelic Composition: Usp18ity9/Usp18tm1Dez Genetic Background: involves: 129 * C57BL/6 * FVB/N
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MP:0000522 | cysts in kidney cortex | "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844] |
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Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
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MP:0000527 | abnormal kidney development | "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Apptm1Ck/Apptm1Ck,Psen1tm1Mpm/Psen1tm1Mpm,Tg(MAPT)8cPdav/0 Genetic Background: B6.Cg-Psen1tm1Mpm Apptm1Ck Tg(MAPT)8cPdav
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MP:0000533 | kidney hemorrhage | "bleeding in the organ of excretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
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MP:0000933 | abnormal rhombomere morphology | "malformation of the transverse segments in the hindbrain region of the developing neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776] |
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Allelic Composition: Recktm1Ito/Recktm1Ito Genetic Background: involves: 129P2/OlaHsd
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MP:0001394 | circling | "repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295] |
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Allelic Composition: Dlx5tm1Jlr/Dlx5+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0001399 | hyperactivity | "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125] |
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Allelic Composition: Dlx5tm1Jlr/Dlx5+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0001575 | cyanosis | "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159] |
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Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+ Genetic Background: involves: 129S2/SvPas * LPT/LeJ
Allelic Composition: Mafbtm1.2Good/Mafbtm1.2Good Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
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MP:0001922 | reduced male fertility | "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340] |
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Allelic Composition: Dlx5tm1Jlr/Dlx5+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0001923 | reduced female fertility | "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409] |
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Allelic Composition: Dlx5tm1Jlr/Dlx5+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0001943 | abnormal respiration | "anomaly in the movement of gases into and out of the lung " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+ Genetic Background: involves: 129S2/SvPas * LPT/LeJ
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MP:0001951 | abnormal breathing | "irregular or atypical breathing pattern " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:17489] |
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Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+ Genetic Background: involves: 129S2/SvPas * LPT/LeJ
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MP:0001953 | respiratory failure | "cessation of or failure to commence breathing" [MGI:cls, J:60159] |
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Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+ Genetic Background: involves: 129S2/SvPas * LPT/LeJ
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MP:0001954 | respiratory distress | "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931] |
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Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+ Genetic Background: involves: 129S2/SvPas * LPT/LeJ
Allelic Composition: Mafbtm1.2Good/Mafbtm1.2Good Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
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MP:0001957 | apnea | "absence of breathing; sometimes episodic" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17384] |
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Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+ Genetic Background: involves: 129S2/SvPas * LPT/LeJ
Allelic Composition: Mafbtm1.1Good/Mafbtm1Jeng,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL
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MP:0002135 | abnormal kidney morphology | "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
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MP:0002151 | abnormal neural tube morphology/development | "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Dlx5tm1Jlr/Dlx5+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Apptm1Ck/Apptm1Ck,Psen1tm1Mpm/Psen1tm1Mpm,Tg(MAPT)8cPdav/0 Genetic Background: B6.Cg-Psen1tm1Mpm Apptm1Ck Tg(MAPT)8cPdav
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MP:0002428 | abnormal semicircular canal | "anomaly of the organ of balance composed of three long bony tubes of the labyrinth" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Usp18ity9/Usp18tm1Dez Genetic Background: involves: 129 * C57BL/6 * FVB/N
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MP:0002703 | abnormal renal tubules | "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
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MP:0002855 | abnormal cochlear ganglion morphology | "malformation, malfunction or absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Mafbtm1.1Good/Mafbtm1Jeng,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL
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MP:0003077 | abnormal cell cycle | "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266] |
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Allelic Composition: Usp18ity9/Usp18tm1Dez Genetic Background: involves: 129 * C57BL/6 * FVB/N
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MP:0003308 | abnormal cochlear sensory epithelium | |
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Allelic Composition: Dlx5tm1Jlr/Dlx5+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0003624 | anuria | "inability to form or excrete urine" [ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
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MP:0003633 | abnormal nervous system physiology | |
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Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+ Genetic Background: involves: 129S2/SvPas * LPT/LeJ
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MP:0004045 | abnormal cell cycle checkpoint function | "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Mafbkr/Mafbkr Genetic Background: CBA.Cg-Mafbkr
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MP:0004153 | increased renal tubule apoptosis | "increase in the number of renal tubule cells undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
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MP:0004289 | abnormal bony labyrinth | "any structural abnormality in the series of cavities (cochlea, vestibule, and semicircular canals) contained within the otic capsule of the petrous portion of the temporal bone; the bony labyrinth is filled with perilymph, in which the delicate, endolymph-filled membranous labyrinth is suspended" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dlx5tm1Jlr/Dlx5+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0004505 | decreased renal glomerulus number | "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mafbtm1Jeng/Mafbtm1Jeng Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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MP:0004562 | abnormal inner hair cell synaptic ribbon morphology | "any structural abnormality in the presynaptic active zone of mature cochlear IHCs which usually contain a single synaptic ribbon, i.e. a submicrometer, electron-dense structure tethering synaptic vesicles; each spiral ganglion neuron receives input from only one IHC synapse" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mafbtm1.1Good/Mafbtm1Jeng,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL
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MP:0005277 | abnormal brainstem morphology | "anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670] |
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Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+ Genetic Background: involves: 129S2/SvPas * LPT/LeJ
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MP:0005307 | head tossing | "compulsive flailing of the head in multiple directions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Dlx5tm1Jlr/Dlx5+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0005553 | increased circulating creatinine level | "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: S1pr2tm1Ajml/S1pr2tm1Ajml Genetic Background: involves: 129S5/SvEvBrd * C57BL/6
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MP:0006011 | abnormal endolymphatic duct morphology | "any structural alteration in the small membranous canal, connecting with both saccule and utricle of the membranous labyrinth, passing through the aqueduct of vestibule, and terminating in the endolymphatic sac." [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Usp18ity9/Usp18tm1Dez Genetic Background: involves: 129 * C57BL/6 * FVB/N
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MP:0006030 | abnormal otic vesicle formation | "anomalous formation of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:] |
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Allelic Composition: Dlx5tm1Jlr/Dlx5+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Mafbkr/Mafbkr Genetic Background: CBA.Cg-Mafbkr
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MP:0006108 | abnormal hindbrain development | "anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573] |
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Allelic Composition: Dlx5tm1Jlr/Dlx5+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0006287 | inner ear cysts | "abnormal membranous sacs in any component of the labyrinth, including the semicircular canals, vestibule and cochlea" [J:111415, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dlx5tm1Jlr/Dlx5+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Mafbtm1Jeng/Mafbtm1Jeng Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Mafbkr/Mafbkr Genetic Background: CBA.Cg-Mafbkr
Allelic Composition: Mafbtm1.2Good/Mafbtm1.2Good Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
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MP:0008139 | fused podocyte foot processes | "coalescence of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries " [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Mafbtm1Jeng/Mafbtm1Jeng Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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MP:0009913 | abnormal hyoid bone greater horn morphology | "any structural anomaly of the larger and more lateral of the paired processes on either side of the hyoid bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Recktm1Ito/Recktm1Ito Genetic Background: involves: 129P2/OlaHsd
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MP:0010395 | abnormal branchial arch development | "abnormal formation of the of the transient structures of the embryo that develop into regions of the head, neck and ears" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Recktm1Ito/Recktm1Ito Genetic Background: involves: 129P2/OlaHsd
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MP:0010396 | ectopic branchial arch | "abnormal location of any of the transient structures of the embryo resulting in misplaced regions of the head, neck and/or ears" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Recktm1Ito/Recktm1Ito Genetic Background: involves: 129P2/OlaHsd
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MP:0010397 | abnormal otic capsule development | "any anomaly in the embryonic cartilage covering that surrounds the inner ear mechanism and develops into bone" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dlx5tm1Jlr/Dlx5+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0011087 | complete neonatal lethality | "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Mafbtm1Jeng/Mafbtm1Jeng Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Mafbtm1.2Good/Mafbtm1.2Good Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL
Allelic Composition: Mafbtm1.1Good/Mafbtm1Jeng,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL
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MP:0011089 | complete perinatal lethality | "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+ Genetic Background: involves: 129S2/SvPas * LPT/LeJ
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MP:0011932 | abnormal endocrine pancreas development | |
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Allelic Composition: X/SryAKR/J,Tht/Tht+ Genetic Background: involves: AKR/J * C57BL/6J
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MP:0011967 | increased or absent threshold for auditory brainstem response | "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith] |
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Allelic Composition: Mafbtm1.1Good/Mafbtm1Jeng,Foxg1tm1(cre)Skm/Foxg1+ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL
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MP:0012796 | abnormal rhombomere 4 morphology | "any structural anomaly of the fourth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [MGI:anna, MGI:csmith, UBERON:0005511] |
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Allelic Composition: Dlx5tm1Jlr/Dlx5+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0012800 | abnormal rhombomere 5 morphology | "any structural anomaly of the fifth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order" [MGI:anna, MGI:csmith, UBERON:0005515] |
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Allelic Composition: Dlx5tm1Jlr/Dlx5+ Genetic Background: involves: 129X1/SvJ * C57BL/6J
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MP:0014167 | ectopic bone | "the appearance of an extra bone structure at an atypical location" [MGI:csmith] |
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Allelic Composition: Recktm1Ito/Recktm1Ito Genetic Background: involves: 129P2/OlaHsd
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