ENSMUSG00000051510


Mus musculus

Features
Gene ID: ENSMUSG00000051510
  
Biological name :Mafg
  
Synonyms : Mafg / O54790 / Transcription factor MafG
  
Possible biological names infered from orthology : MAF bZIP transcription factor G / O15525
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 120625117
Gene end: 120633600
  
Corresponding Affymetrix probe sets: 10393877 (MoGene1.0st)   10393879 (MoGene1.0st)   10393881 (MoGene1.0st)   1434054_at (Mouse Genome 430 2.0 Array)   1448916_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000053899
Ensembl peptide - ENSMUSP00000101786
Ensembl peptide - ENSMUSP00000101787
Ensembl peptide - ENSMUSP00000101788
NCBI entrez gene - 17134     See in Manteia.
MGI - MGI:96911
RefSeq - XM_017314311
RefSeq - NM_010756
RefSeq - XM_017314309
RefSeq - XM_017314310
RefSeq - XM_017314307
RefSeq - XM_017314308
RefSeq Peptide - NP_034886
swissprot - O54790
Ensembl - ENSMUSG00000051510
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mafgaENSDARG00000018109Danio rerio
 mafgbENSDARG00000100097Danio rerio
 MAFGENSGALG00000031475Gallus gallus
 MAFGENSG00000197063Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mafk / Q61827 / v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) / O60675* / MAF bZIP transcription factor K*ENSMUSG0000001814372
Maff / O54791 / Transcription factor MafF / Q9ULX9* / MAF bZIP transcription factor F*ENSMUSG0000004262260
Maf / P54843 / Transcription factor Maf / O75444* / MAF bZIP transcription factor*ENSMUSG0000005543541
Mafb / P54841 / Transcription factor MafB / Q9Y5Q3* / MAF bZIP transcription factor B*ENSMUSG0000007462241
Mafa / Q8CF90 / Transcription factor MafA / Q8NHW3* / MAF bZIP transcription factor A*ENSMUSG0000004759138
Nrl / P54846 / Neural retina-specific leucine zipper protein / P54845* / neural retina leucine zipper*ENSMUSG0000004063233


Protein motifs (from Interpro)
Interpro ID Name
 IPR004826  Basic leucine zipper domain, Maf-type
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR024874  Transcription factor Maf family
 IPR028551  Transcription factor MafG


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0010628 positive regulation of gene expression IGI
 biological_processGO:0030534 adult behavior IMP
 biological_processGO:0030641 regulation of cellular pH IEA
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0045604 regulation of epidermal cell differentiation IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IPI
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity TAS


Pathways (from Reactome)
Pathway description
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000229 abnormal megakaryocyte differentiation "atypical process of formation and development these very large bone marrow cells which release mature platelets" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sod2tm1.1Kskk/Sod2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafk+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafktm1Jeng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000243 myoclonus "involuntary shock-like contractions, variable in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles; generally due to a central nervous system lesion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafk+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafktm1Jeng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Sod2tm1.1Kskk/Sod2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafktm1Jeng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafktm1Jeng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafk+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sod2tm1.1Kskk/Sod2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sod2tm1.1Kskk/Sod2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafktm1Jeng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafk+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafktm1Jeng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafktm1Jeng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafktm1Jeng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafk+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Sod2tm1.1Kskk/Sod2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafktm1Jeng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafk+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003657 abnormal erythrocyte lysis "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafktm1Jeng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafktm1Jeng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafktm1Jeng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Sod2tm1.1Kskk/Sod2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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