ENSMUSG00000018143


Mus musculus

Features
Gene ID: ENSMUSG00000018143
  
Biological name :Mafk
  
Synonyms : Mafk / Q61827 / v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)
  
Possible biological names infered from orthology : MAF bZIP transcription factor K / O60675
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G2
Gene start: 139791513
Gene end: 139802653
  
Corresponding Affymetrix probe sets: 10526961 (MoGene1.0st)   1418616_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018287
Ensembl peptide - ENSMUSP00000106460
NCBI entrez gene - 17135     See in Manteia.
MGI - MGI:99951
RefSeq - XM_006504653
RefSeq - NM_010757
RefSeq Peptide - NP_034887
swissprot - Q3UP84
swissprot - Q61827
Ensembl - ENSMUSG00000018143
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mafkENSDARG00000100947Danio rerio
 MAFKENSGALG00000004189Gallus gallus
 MAFKENSG00000198517Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mafg / O54790 / Transcription factor MafG / O15525* / MAF bZIP transcription factor G*ENSMUSG0000005151074
Maff / O54791 / Transcription factor MafF / Q9ULX9* / MAF bZIP transcription factor F*ENSMUSG0000004262265
Mafb / P54841 / Transcription factor MafB / Q9Y5Q3* / MAF bZIP transcription factor B*ENSMUSG0000007462247
Maf / P54843 / Transcription factor Maf / O75444* / MAF bZIP transcription factor*ENSMUSG0000005543543
Mafa / Q8CF90 / Transcription factor MafA / Q8NHW3* / MAF bZIP transcription factor A*ENSMUSG0000004759142
Nrl / P54846 / Neural retina-specific leucine zipper protein / P54845* / neural retina leucine zipper*ENSMUSG0000004063235


Protein motifs (from Interpro)
Interpro ID Name
 IPR004826  Basic leucine zipper domain, Maf-type
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR024874  Transcription factor Maf family
 IPR028574  Transcription factor MafK


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0007399 nervous system development IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0001221 transcription cofactor binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0071535 RING-like zinc finger domain binding IEA


Pathways (from Reactome)
Pathway description
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000229 abnormal megakaryocyte differentiation "atypical process of formation and development these very large bone marrow cells which release mature platelets" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafk+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafktm1Jeng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000243 myoclonus "involuntary shock-like contractions, variable in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles; generally due to a central nervous system lesion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafk+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafktm1Jeng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafktm1Jeng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafktm1Jeng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafk+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafktm1Jeng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafk+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafktm1Jeng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002447 abnormal erythrocyte morphology "structural anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafktm1Jeng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafktm1Jeng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafk+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafktm1Jeng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafk+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003657 abnormal erythrocyte lysis "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafktm1Jeng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafktm1Jeng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Mafgtm1Jeng/Mafgtm1Jeng,Mafktm1Jeng/Mafktm1Jeng
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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