ENSMUSG00000055435


Mus musculus

Features
Gene ID: ENSMUSG00000055435
  
Biological name :Maf
  
Synonyms : Maf / P54843 / Transcription factor Maf
  
Possible biological names infered from orthology : MAF bZIP transcription factor / O75444
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: E1
Gene start: 115682942
Gene end: 115707794
  
Corresponding Affymetrix probe sets: 10581992 (MoGene1.0st)   1435828_at (Mouse Genome 430 2.0 Array)   1437473_at (Mouse Genome 430 2.0 Array)   1444073_at (Mouse Genome 430 2.0 Array)   1447849_s_at (Mouse Genome 430 2.0 Array)   1447945_at (Mouse Genome 430 2.0 Array)   1456060_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000067704
Ensembl peptide - ENSMUSP00000104732
NCBI entrez gene - 17132     See in Manteia.
MGI - MGI:96909
RefSeq - NM_001025577
RefSeq Peptide - NP_001020748
swissprot - P54843
Ensembl - ENSMUSG00000055435
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mafaENSDARG00000015890Danio rerio
 mafbENSDARG00000076520Danio rerio
 MAFENSGALG00000026258Gallus gallus
 MAFENSG00000178573Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mafb / P54841 / Transcription factor MafB / Q9Y5Q3* / MAF bZIP transcription factor B*ENSMUSG0000007462252
Mafa / Q8CF90 / Transcription factor MafA / Q8NHW3* / MAF bZIP transcription factor A*ENSMUSG0000004759152
Nrl / P54846 / Neural retina-specific leucine zipper protein / P54845* / neural retina leucine zipper*ENSMUSG0000004063233
Maff / O54791 / Transcription factor MafF / Q9ULX9* / MAF bZIP transcription factor F*ENSMUSG0000004262218
Mafg / O54790 / Transcription factor MafG / O15525* / MAF bZIP transcription factor G*ENSMUSG0000005151018
Mafk / Q61827 / v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) / O60675* / MAF bZIP transcription factor K*ENSMUSG0000001814318


Protein motifs (from Interpro)
Interpro ID Name
 IPR004826  Basic leucine zipper domain, Maf-type
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR013592  Maf transcription factor, N-terminal
 IPR024874  Transcription factor Maf family
 IPR028573  Transcription factor Maf


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001816 cytokine production IDA
 biological_processGO:0002088 lens development in camera-type eye IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IMP
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0032330 regulation of chondrocyte differentiation IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048468 cell development IMP
 biological_processGO:0048839 inner ear development IDA
 biological_processGO:0070306 lens fiber cell differentiation IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mitftm3.1Arnh/Mitftm3.1Arnh,Pax6Sey-Neu/Pax6+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0000435 shortened head "reduced anterior-posterior length of the head" [J:42035]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0000982 abnormal Meissner s corpuscle morphology "structural anomaly of any of the numerous oval bodies found in the dermal papillae of thick skin; believed to be mechanorecptors for tactile sensation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mitftm3.1Arnh/Mitftm3.1Arnh,Pax6Sey-Neu/Pax6+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0000988 abnormal pacinian corpuscle morphology "anomalous structure of any of the rapidly adapting mechanoreceptors found in subcutaneous tissue beneath both hairy and glabrous skin, and which normally contain an afferent nerve fiber surrounded by a capsule with multiple concentric layers" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mitftm3.1Arnh/Mitftm3.1Arnh,Pax6Sey-Neu/Pax6+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Mitftm3.1Arnh/Mitftm3.1Arnh,Pax6Sey-Neu/Pax6+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0001288 abnormal lens induction "malformation of or failure to form the transparent, biconvex structure of the eye which is situated behind the iris and in front of the vitreous humor" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0001292 abnormal lens vesicle development "malformation or abnormal patterning of the lens vesicle of the eye" [J:49424]
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Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Hand2tm1Dsr/Hand2tm1Dsr
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001320 small pupils "smaller than normal size of the central circular aperture of the iris through which light rays enter the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mitftm3.1Arnh/Mitftm3.1Arnh,Pax6Sey-Neu/Pax6+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001759 increased urine glucose level "a greater level of excretion of glucose in the urine compared to the normal state" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ntan1tm1Avar/Ntan1tm1Avar,Ubr1tm1Avar/Ubr1tm1Avar
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mitftm3.1Arnh/Mitftm3.1Arnh,Pax6Sey-Neu/Pax6+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0002638 abnormal pupillary reflex "alterations or failure of the pupil to change in diamater as a reflex response to any stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0002704 tubular nephritis "inflammation of the renal tubules" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0002840 abnormal lens fibers morphology "structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pdx1tm1Cvw/Pdx1tm4Cvw,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6 * DBA

 MP:0005301 abnormal corneal endothelium morphology "anomalous structure of the single layer of large flattened cells that cover the surface of the cornea" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mitftm3.1Arnh/Mitftm3.1Arnh,Pax6Sey-Neu/Pax6+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mitftm3.1Arnh/Mitftm3.1Arnh,Pax6Sey-Neu/Pax6+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

 MP:0005545 abnormal lens development "aberrant formation of the transparent structure of the eye responsible for focusing light rays" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

Allelic Composition: Maftm1Mym/Maftm1Mym
Genetic Background: either: (involves: 129/Sv * C57BL/6J) or (involves: 129/Sv * ICR)

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Maftm1.1Cbm/Maftm2.1Cbm,Isl1tm1(cre)Tmj/Isl1+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL

 MP:0010254 nuclear cataracts "a lens opacity located in the dense, central part of the lens" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
Show

Allelic Composition: Pygo2tm1.2Xdai/Pygo2tm1.2Xdai
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: MafENU424/Maf+
Genetic Background: involves: 102/El * C3H/El * C57BL/6El

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

Allelic Composition: Maftm1Mym/Maftm1Mym
Genetic Background: either: (involves: 129/Sv * C57BL/6J) or (involves: 129/Sv * ICR)

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Maftm1Mym/Maftm1Mym
Genetic Background: either: (involves: 129/Sv * C57BL/6J) or (involves: 129/Sv * ICR)

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0011962 increased cornea thickness "increased width of the cornea in the center plane" [MGI:csmith]
Show

Allelic Composition: Otx2tm1Sia/Otx2+
Genetic Background: involves: C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039153 Runx2 / Q08775 / runt related transcription factor 2 / Q13950*  / reaction / complex






 

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