ENSMUSG00000047591


Mus musculus

Features
Gene ID: ENSMUSG00000047591
  
Biological name :Mafa
  
Synonyms : Mafa / Q8CF90 / Transcription factor MafA
  
Possible biological names infered from orthology : MAF bZIP transcription factor A / Q8NHW3
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D3
Gene start: 75745490
Gene end: 75748228
  
Corresponding Affymetrix probe sets: 10429621 (MoGene1.0st)   1436092_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000054226
NCBI entrez gene - 378435     See in Manteia.
MGI - MGI:2673307
RefSeq - NM_194350
RefSeq Peptide - NP_919331
swissprot - Q8CF90
Ensembl - ENSMUSG00000047591
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mafaaENSDARG00000044155Danio rerio
 MAFAENSGALG00000026264Gallus gallus
 MAFAENSG00000182759Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Maf / P54843 / Transcription factor Maf / O75444* / MAF bZIP transcription factor*ENSMUSG0000005543554
Mafb / P54841 / Transcription factor MafB / Q9Y5Q3* / MAF bZIP transcription factor B*ENSMUSG0000007462251
Nrl / P54846 / Neural retina-specific leucine zipper protein / P54845* / neural retina leucine zipper*ENSMUSG0000004063234
Maff / O54791 / Transcription factor MafF / Q9ULX9* / MAF bZIP transcription factor F*ENSMUSG0000004262218
Mafk / Q61827 / v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) / O60675* / MAF bZIP transcription factor K*ENSMUSG0000001814318
Mafg / O54790 / Transcription factor MafG / O15525* / MAF bZIP transcription factor G*ENSMUSG0000005151017


Protein motifs (from Interpro)
Interpro ID Name
 IPR004826  Basic leucine zipper domain, Maf-type
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR013592  Maf transcription factor, N-terminal
 IPR024874  Transcription factor Maf family
 IPR028562  Transcription factor MafA


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007263 nitric oxide mediated signal transduction IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0030073 insulin secretion IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abca5tm1Akya/Abca5tm1Akya
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * ICR

 MP:0001759 increased urine glucose level "a greater level of excretion of glucose in the urine compared to the normal state" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Abca5tm1Akya/Abca5tm1Akya
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * ICR

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dmdmdx/Dmdmdx,Dusp1tm1Brv/Dusp1tm1Brv
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/10ScSn

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abca5tm1Akya/Abca5tm1Akya
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * ICR

Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Abca5tm1Akya/Abca5tm1Akya
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * ICR

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Abca5tm1Akya/Abca5tm1Akya
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * ICR

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Abca5tm1Akya/Abca5tm1Akya
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * ICR

Allelic Composition: Mafatm1Staka/Mafa+
Genetic Background: involves: ICR

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Abca5tm1Akya/Abca5tm1Akya
Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * ICR

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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