ENSG00000198517


Homo sapiens

Features
Gene ID: ENSG00000198517
  
Biological name :MAFK
  
Synonyms : MAF bZIP transcription factor K / MAFK / O60675
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: p22.3
Gene start: 1530714
Gene end: 1543043
  
Corresponding Affymetrix probe sets: 206750_at (Human Genome U133 Plus 2.0 Array)   226206_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000385437
Ensembl peptide - ENSP00000386009
Ensembl peptide - ENSP00000344903
NCBI entrez gene - 7975     See in Manteia.
OMIM - 600197
RefSeq - NM_002360
RefSeq - XM_005249851
RefSeq - XM_006715773
RefSeq Peptide - NP_002351
swissprot - A0A024R804
swissprot - O60675
Ensembl - ENSG00000198517
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mafkENSDARG00000100947Danio rerio
 MAFKENSGALG00000004189Gallus gallus
 MafkENSMUSG00000018143Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAFG / O15525 / MAF bZIP transcription factor GENSG0000019706375
MAFF / Q9ULX9 / MAF bZIP transcription factor FENSG0000018502265
MAFB / Q9Y5Q3 / MAF bZIP transcription factor BENSG0000020410347
MAF / O75444 / MAF bZIP transcription factorENSG0000017857343
MAFA / Q8NHW3 / MAF bZIP transcription factor AENSG0000018275942
NRL / P54845 / neural retina leucine zipperENSG0000012953536


Protein motifs (from Interpro)
Interpro ID Name
 IPR004826  Basic leucine zipper domain, Maf-type
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR024874  Transcription factor Maf family
 IPR028574  Transcription factor MafK


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007596 blood coagulation TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001221 transcription cofactor binding IEA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0071535 RING-like zinc finger domain binding IEA


Pathways (from Reactome)
Pathway description
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000123405 NFE2 / Q16621 / nuclear factor, erythroid 2  / complex / reaction






 

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