ENSG00000123405


Homo sapiens

Features
Gene ID: ENSG00000123405
  
Biological name :NFE2
  
Synonyms : NFE2 / nuclear factor, erythroid 2 / Q16621
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q13.13
Gene start: 54292111
Gene end: 54301121
  
Corresponding Affymetrix probe sets: 209930_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000312436
Ensembl peptide - ENSP00000439120
Ensembl peptide - ENSP00000446929
Ensembl peptide - ENSP00000447558
Ensembl peptide - ENSP00000397185
NCBI entrez gene - 4778     See in Manteia.
OMIM - 601490
RefSeq - XM_005268906
RefSeq - NM_001136023
RefSeq - NM_001261461
RefSeq - NM_006163
RefSeq Peptide - NP_001129495
RefSeq Peptide - NP_001248390
RefSeq Peptide - NP_006154
swissprot - A8K3E0
swissprot - F8W1N9
swissprot - Q16621
Ensembl - ENSG00000123405
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfe2ENSDARG00000020606Danio rerio
 Nfe2ENSMUSG00000058794Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NFE2L1 / Q14494 / nuclear factor, erythroid 2 like 1ENSG0000008264137
NFE2L2 / Q16236 / nuclear factor, erythroid 2 like 2ENSG0000011604434
NFE2L3 / Q9Y4A8 / nuclear factor, erythroid 2 like 3ENSG0000005034432
BACH1 / O14867 / BTB domain and CNC homolog 1ENSG0000015627321
BACH2 / Q9BYV9 / BTB domain and CNC homolog 2ENSG0000011218218


Protein motifs (from Interpro)
Interpro ID Name
 IPR004826  Basic leucine zipper domain, Maf-type
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR029853  Transcription factor NF-E2, 45kDa subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006337 nucleosome disassembly TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0007599 hemostasis TAS
 biological_processGO:0008015 blood circulation TAS
 biological_processGO:0045652 regulation of megakaryocyte differentiation TAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0032993 protein-DNA complex IDA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding TAS
 molecular_functionGO:0047485 protein N-terminus binding IPI
 molecular_functionGO:0050699 WW domain binding IDA


Pathways (from Reactome)
Pathway description
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000197063 MAFG / O15525 / MAF bZIP transcription factor G  / reaction / complex
 ENSG00000185022 MAFF / Q9ULX9 / MAF bZIP transcription factor F  / reaction / complex
 ENSG00000198517 MAFK / O60675 / MAF bZIP transcription factor K  / reaction / complex






 

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