ENSG00000082641


Homo sapiens

Features
Gene ID: ENSG00000082641
  
Biological name :NFE2L1
  
Synonyms : NFE2L1 / nuclear factor, erythroid 2 like 1 / Q14494
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q21.32
Gene start: 48048329
Gene end: 48061487
  
Corresponding Affymetrix probe sets: 200758_s_at (Human Genome U133 Plus 2.0 Array)   200759_x_at (Human Genome U133 Plus 2.0 Array)   214179_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000464018
Ensembl peptide - ENSP00000463960
Ensembl peptide - ENSP00000464203
Ensembl peptide - ENSP00000464446
Ensembl peptide - ENSP00000350072
Ensembl peptide - ENSP00000354855
Ensembl peptide - ENSP00000355190
Ensembl peptide - ENSP00000445811
Ensembl peptide - ENSP00000461960
Ensembl peptide - ENSP00000461971
Ensembl peptide - ENSP00000462003
Ensembl peptide - ENSP00000462253
Ensembl peptide - ENSP00000462444
Ensembl peptide - ENSP00000462610
Ensembl peptide - ENSP00000462971
Ensembl peptide - ENSP00000463291
Ensembl peptide - ENSP00000463657
Ensembl peptide - ENSP00000463744
Ensembl peptide - ENSP00000463836
NCBI entrez gene - 4779     See in Manteia.
OMIM - 163260
RefSeq - NM_001330261
RefSeq - NM_001330262
RefSeq - NM_003204
RefSeq - XM_005257410
RefSeq - XM_005257411
RefSeq - XM_005257412
RefSeq - XM_005257413
RefSeq - XM_005257415
RefSeq - XM_017024691
RefSeq Peptide - NP_001317191
RefSeq Peptide - NP_003195
RefSeq Peptide - NP_001317190
swissprot - J3QR31
swissprot - J3QRG7
swissprot - J9JIE5
swissprot - A0A0G2JLG9
swissprot - Q14494
swissprot - B4DYE1
swissprot - F5H1B7
swissprot - J3KRF3
swissprot - J3KSE0
swissprot - J3KSR3
swissprot - J3KTG6
swissprot - J3QKY3
swissprot - J3QQH8
swissprot - J3QLQ1
swissprot - J3QQQ1
swissprot - J3QQY8
Ensembl - ENSG00000082641
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfe2l1aENSDARG00000030616Danio rerio
 NFE2L1ENSGALG00000011937Gallus gallus
 Nfe2l1ENSMUSG00000038615Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NFE2L3 / Q9Y4A8 / nuclear factor, erythroid 2 like 3ENSG0000005034433
NFE2L2 / Q16236 / nuclear factor, erythroid 2 like 2ENSG0000011604424
NFE2 / Q16621 / nuclear factor, erythroid 2ENSG0000012340518
BACH1 / O14867 / BTB domain and CNC homolog 1ENSG0000015627315
BACH2 / Q9BYV9 / BTB domain and CNC homolog 2ENSG0000011218213


Protein motifs (from Interpro)
Interpro ID Name
 IPR004826  Basic leucine zipper domain, Maf-type
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR029847  Nuclear factor erythroid 2-related factor 1/NFE2L1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006783 heme biosynthetic process TAS
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0009653 anatomical structure morphogenesis TAS
 biological_processGO:0030218 erythrocyte differentiation IEA
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003712 transcription coregulator activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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