ENSMUSG00000038615


Mus musculus

Features
Gene ID: ENSMUSG00000038615
  
Biological name :Nfe2l1
  
Synonyms : Nfe2l1 / Nuclear factor erythroid 2-related factor 1 / Q61985
  
Possible biological names infered from orthology : nuclear factor, erythroid 2 like 1 / Q14494
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 96817414
Gene end: 96829968
  
Corresponding Affymetrix probe sets: 10390271 (MoGene1.0st)   1416331_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127804
Ensembl peptide - ENSMUSP00000121423
Ensembl peptide - ENSMUSP00000128527
Ensembl peptide - ENSMUSP00000131585
Ensembl peptide - ENSMUSP00000080467
Ensembl peptide - ENSMUSP00000103284
Ensembl peptide - ENSMUSP00000103285
Ensembl peptide - ENSMUSP00000103286
Ensembl peptide - ENSMUSP00000120512
NCBI entrez gene - 18023     See in Manteia.
MGI - MGI:99421
RefSeq - XM_011248790
RefSeq - NM_001130450
RefSeq - NM_001130451
RefSeq - NM_001130452
RefSeq - NM_001130453
RefSeq - NM_001130454
RefSeq - NM_008686
RefSeq Peptide - NP_001123922
RefSeq Peptide - NP_001123923
RefSeq Peptide - NP_001123926
RefSeq Peptide - NP_032712
RefSeq Peptide - NP_001123924
RefSeq Peptide - NP_001123925
swissprot - Q61985
swissprot - A2A6D0
swissprot - A2A6D2
swissprot - A2A6D1
swissprot - Q3V3M1
swissprot - Q6GTN8
Ensembl - ENSMUSG00000038615
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfe2l1aENSDARG00000030616Danio rerio
 NFE2L1ENSGALG00000011937Gallus gallus
 NFE2L1ENSG00000082641Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nfe2l3 / Q9WTM4 / nuclear factor, erythroid derived 2, like 3 / Q9Y4A8* / nuclear factor, erythroid 2 like 3*ENSMUSG0000002983230
Nfe2l2 / Q60795 / Nuclear factor erythroid 2-related factor 2 / Q16236* / nuclear factor, erythroid 2 like 2*ENSMUSG0000001583924
Nfe2 / nuclear factor, erythroid 2 / Q16621*ENSMUSG0000005879418
Bach1 / P97302 / Transcription regulator protein BACH1 / O14867* / BTB domain and CNC homolog 1*ENSMUSG0000002561215
Bach2 / P97303 / Transcription regulator protein BACH2 / Q9BYV9* / BTB domain and CNC homolog 2*ENSMUSG0000004027012


Protein motifs (from Interpro)
Interpro ID Name
 IPR004826  Basic leucine zipper domain, Maf-type
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR029847  Nuclear factor erythroid 2-related factor 1/NFE2L1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0030218 erythrocyte differentiation IMP
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IDA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0044877 protein-containing complex binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000601 small liver "reduced size of the liver" [J:23170]
Show

Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
Show

Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Scarb1Hlb398/?
Genetic Background: C57BL/6J-Scarb1Hlb398

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001693 failure of primitive streak formation "inability to form the epiblast ridge from which arises the germ layers of the embryo" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
Show

Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Nfe2l1tm1Ywk/Nfe2l1tm1Ywk,Nfe2l2tm1Ywk/Nfe2l2tm1Ywk
Genetic Background: involves: 129X1/SvJ

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Nfe2l1tm1Jefc/Nfe2l1tm1Ywk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfe2l1tm1Jefc/Nfe2l1tm1Ywk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Nfe2l1tm1Mym/Nfe2l1tm1Mym,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccar2tm1Dac/Ccar2tm1Dac,Lepob/Lepob
Genetic Background: involves: 129 * C57BL/6J

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nfe2l1tm1Jefc/Nfe2l1tm1Ywk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Nfe2l1tm1Mym/Nfe2l1tm1Mym,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0003324 liver adenoma "benign epithelial neoplasm of the liver" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Nfe2l1tm1Jefc/Nfe2l1tm1Ywk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Nfe2l1tm1Jefc/Nfe2l1tm1Ywk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Nfe2l1tm1Jefc/Nfe2l1tm1Ywk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nfe2l2tm1Ywk/Nfe2l2tm1Ywk
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Nfe2l1tm1Ywk/Nfe2l1tm1Ywk,Nfe2l2tm1Ywk/Nfe2l2tm1Ywk
Genetic Background: involves: 129X1/SvJ

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Nfe2l1tm1Ywk/Nfe2l1tm1Ywk,Nfe2l2tm1Ywk/Nfe2l2tm1Ywk
Genetic Background: involves: 129X1/SvJ

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Nfe2l1tm1Mym/Nfe2l1tm1Mym,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ccar2tm1Dac/Ccar2tm1Dac,Lepob/Lepob
Genetic Background: involves: 129 * C57BL/6J

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfe2l1tm1Ywk/Nfe2l1tm1Ywk,Nfe2l2tm1Ywk/Nfe2l2tm1Ywk
Genetic Background: involves: 129X1/SvJ

 MP:0008412 increased cellular sensitivity to oxidative stress "greater incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfe2l1tm1Ywk/Nfe2l1tm1Ywk,Nfe2l2tm1Ywk/Nfe2l2tm1Ywk
Genetic Background: involves: 129X1/SvJ

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Nfe2l1tm1Ywk/Nfe2l1tm1Ywk,Nfe2l2tm1Ywk/Nfe2l2tm1Ywk
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Nfe2l1tm1.1Mym/Nfe2l1tm1.1Mym
Genetic Background: involves: C57BL/6J

 MP:0011106 partial embryonic lethality before somite formation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Nfe2l1tm1Ywk/Nfe2l1tm1Ywk,Nfe2l2tm1Ywk/Nfe2l2tm1Ywk
Genetic Background: involves: 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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