Manteia

ENSMUSG00000015839

Mus musculus

Features

Gene ID:	ENSMUSG00000015839

Biological name :	Nfe2l2

Synonyms :	Nfe2l2 / Nuclear factor erythroid 2-related factor 2 / Q60795

Possible biological names infered from orthology :	nuclear factor, erythroid 2 like 2 / Q16236

Species:	Mus musculus

Chr. number:	2
Strand:	-1
Band:	C3
Gene start:	75675513
Gene end:	75704641

Corresponding Affymetrix probe sets:	10483809 (MoGene1.0st) 1416543_at (Mouse Genome 430 2.0 Array) 1457117_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000099733 NCBI entrez gene - 18024 See in Manteia. MGI - MGI:108420 RefSeq - NM_010902 RefSeq Peptide - NP_035032 swissprot - Q60795 Ensembl - ENSMUSG00000015839

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
nfe2l2a	ENSDARG00000042824	Danio rerio
NFE2L2	ENSGALG00000009240	Gallus gallus
NFE2L2	ENSG00000116044	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Nfe2l1 / Q61985 / Nuclear factor erythroid 2-related factor 1 / Q14494* / nuclear factor, erythroid 2 like 1*	ENSMUSG00000038615	30
Nfe2 / nuclear factor, erythroid 2 / Q16621*	ENSMUSG00000058794	22
Nfe2l3 / Q9WTM4 / nuclear factor, erythroid derived 2, like 3 / Q9Y4A8* / nuclear factor, erythroid 2 like 3*	ENSMUSG00000029832	22
Bach2 / P97303 / Transcription regulator protein BACH2 / Q9BYV9* / BTB domain and CNC homolog 2*	ENSMUSG00000040270	17
Bach1 / P97302 / Transcription regulator protein BACH1 / O14867* / BTB domain and CNC homolog 1*	ENSMUSG00000025612	16

Protein motifs (from Interpro)

Interpro ID	Name
IPR004826	Basic leucine zipper domain, Maf-type
IPR004827	Basic-leucine zipper domain
IPR008917	Transcription factor, Skn-1-like, DNA-binding domain superfamily
IPR029845	Nuclear factor erythroid 2-related factor 2

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IDA
biological_process	GO:0006366	transcription by RNA polymerase II	IEA
biological_process	GO:0006954	inflammatory response	IMP
biological_process	GO:0007568	aging	IEA
biological_process	GO:0010499	proteasomal ubiquitin-independent protein catabolic process	IEA
biological_process	GO:0010628	positive regulation of gene expression	IEA
biological_process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	IEA
biological_process	GO:0010976	positive regulation of neuron projection development	IEA
biological_process	GO:0016567	protein ubiquitination	IEA
biological_process	GO:0030194	positive regulation of blood coagulation	IMP
biological_process	GO:0030968	endoplasmic reticulum unfolded protein response	IDA
biological_process	GO:0034599	cellular response to oxidative stress	IDA
biological_process	GO:0034976	response to endoplasmic reticulum stress	IMP
biological_process	GO:0035690	cellular response to drug	IMP
biological_process	GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	IEA
biological_process	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress	IEA
biological_process	GO:0036499	PERK-mediated unfolded protein response	IDA
biological_process	GO:0042149	cellular response to glucose starvation	IMP
biological_process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	IEA
biological_process	GO:0043536	positive regulation of blood vessel endothelial cell migration	IEA
biological_process	GO:0045454	cell redox homeostasis	IMP
biological_process	GO:0045766	positive regulation of angiogenesis	IEA
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IGI
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0045995	regulation of embryonic development	IGI
biological_process	GO:0046223	aflatoxin catabolic process	IEA
biological_process	GO:0046326	positive regulation of glucose import	IDA
biological_process	GO:0060548	negative regulation of cell death	IEA
biological_process	GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	IEA
biological_process	GO:0070301	cellular response to hydrogen peroxide	IEA
biological_process	GO:0071356	cellular response to tumor necrosis factor	IEA
biological_process	GO:0071456	cellular response to hypoxia	IEA
biological_process	GO:0071498	cellular response to fluid shear stress	IEA
biological_process	GO:0071499	cellular response to laminar fluid shear stress	IEA
biological_process	GO:1902037	negative regulation of hematopoietic stem cell differentiation	IMP
biological_process	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IEA
biological_process	GO:1903206	negative regulation of hydrogen peroxide-induced cell death	IEA
biological_process	GO:1903788	positive regulation of glutathione biosynthetic process	IMP
biological_process	GO:1904385	cellular response to angiotensin	IEA
biological_process	GO:1904753	negative regulation of vascular associated smooth muscle cell migration	IEA
biological_process	GO:2000121	regulation of removal of superoxide radicals	IMP
biological_process	GO:2000352	negative regulation of endothelial cell apoptotic process	IEA
biological_process	GO:2000379	positive regulation of reactive oxygen species metabolic process	IMP
cellular_component	GO:0000785	chromatin	IDA
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005654	nucleoplasm	IEA
cellular_component	GO:0005737	cytoplasm	ISO
cellular_component	GO:0005794	Golgi apparatus	IEA
cellular_component	GO:0005813	centrosome	IEA
cellular_component	GO:0005829	cytosol	IDA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0032993	protein-DNA complex	IDA
molecular_function	GO:0000976	transcription regulatory region sequence-specific DNA binding	IEA
molecular_function	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	IDA
molecular_function	GO:0001102	RNA polymerase II activating transcription factor binding	IEA
molecular_function	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding	IDA
molecular_function	GO:0001221	transcription cofactor binding	IEA
molecular_function	GO:0003677	DNA binding	ISO
molecular_function	GO:0003700	DNA-binding transcription factor activity	ISO
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008134	transcription factor binding	IPI
molecular_function	GO:0019904	protein domain specific binding	IEA
molecular_function	GO:0043565	sequence-specific DNA binding	IEA
molecular_function	GO:0046982	protein heterodimerization activity	TAS

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000129	ameloblast degeneration	"a retrogressive impairment of function or destruction of the epithelial cells of the inner later of the enamel organ of the developing tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61509]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd
MP:0000189	hypoglycemia	"low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Scn4a^tm1.1Ljh/Scn4a⁺ Genetic Background: B6.129S4-Scn4a^tm1.1Ljh
MP:0000208	decreased hematocrit	"less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Slc5a3^tm1Gtb/Slc5a3⁺ Genetic Background: involves: 129X1/SvJ
MP:0000272	abnormal aorta morphology	"structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0000313	abnormal cell death	"anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Atm^tm1Fwa/Atm^tm1Fwa Genetic Background: involves: 129S4/SvJae
MP:0000314	schistocytosis	"the appearance of poikilocytes in the blood that owe their abnormal shape to fragmentation occurring as the cells flow through damaged small vessels" [J:82330, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Slc5a3^tm1Gtb/Slc5a3⁺ Genetic Background: involves: 129X1/SvJ
MP:0000603	pale liver	"liver lacking normal coloration, often refers to bloodless condition" [J:18048]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym,n-TUtca2^tm2Mym/n-TUtca2^tm2.1Mym,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0000607	abnormal hepatocyte morphology	"malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym,n-TUtca2^tm2Mym/n-TUtca2^tm2.1Mym,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0000609	abnormal liver physiology	"aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Slc5a3^tm1Gtb/Slc5a3⁺ Genetic Background: involves: 129X1/SvJ
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Slc5a3^tm1Gtb/Slc5a3⁺ Genetic Background: involves: 129X1/SvJ
MP:0000702	enlarged lymph nodes	"lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0001182	lung hemorrhage	"bleeding in the respiratory organs" [J:66345]	Show Allelic Composition: Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: involves: 129X1/SvJ
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Lep^ob/Lep^ob,Nfe2l2^tm1.1Jgpi/Nfe2l2^tm1.1Jgpi,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: C57BL/6 Allelic Composition: Lep^ob/Lep^ob,Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: B6.Cg-Nfe2l2^tm1Mym Lep^ob
MP:0001263	weight loss	"progressive reduction of body weight below normal average for age" [J:45400]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0001394	circling	"repeated, compulsive movement in a circle; often associated with inner ear defects" [MGI:CLS, J:61295]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0001552	increased circulating triglyceride level	"higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Lep^ob/Lep^ob,Nfe2l2^tm1.1Jgpi/Nfe2l2^tm1.1Jgpi,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: C57BL/6 Allelic Composition: Lep^ob/Lep^ob,Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: B6.Cg-Nfe2l2^tm1Mym Lep^ob
MP:0001559	hyperglycemia	"abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Lep^ob/Lep^ob,Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: B6.Cg-Nfe2l2^tm1Mym Lep^ob
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Nfe2^tm1Sho/Nfe2^tm1Sho,Nfe2l2^tm1Ney/Nfe2l2^tm1Ney Genetic Background: involves: 129/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
MP:0001585	hemolytic anemia	"an anemic condition resulting from an increased rate of erythrocyte destruction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Slc5a3^tm1Gtb/Slc5a3⁺ Genetic Background: involves: 129X1/SvJ
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: involves: 129X1/SvJ
MP:0001770	abnormal iron level	"anomalous concentrations of this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0001783	decreased white fat amount	"reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gla^tm1Kul/Y,Tg(A4GALT)#Sais/0 Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms Allelic Composition: Lep^ob/Lep^ob,Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: B6.Cg-Nfe2l2^tm1Mym Lep^ob
MP:0001860	liver inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Scn4a^tm1.1Ljh/Scn4a⁺ Genetic Background: B6.129S4-Scn4a^tm1.1Ljh
MP:0001861	lung inflammation	"local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym,n-TUtca2^tm2Mym/n-TUtca2^tm2.1Mym,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * ICR Allelic Composition: Lep^ob/Lep^ob,Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: B6.Cg-Nfe2l2^tm1Mym Lep^ob
MP:0002100	abnormal tooth morphology	"atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Slc5a3^tm1Gtb/Slc5a3⁺ Genetic Background: involves: 129X1/SvJ Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd
MP:0002133	abnormal respiratory system physiology	"anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Prnp^c/Prnp^c Genetic Background: MAI/Pas
MP:0002451	abnormal macrophage physiology	"abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * ICR Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0002463	abnormal neutrophil physiology	"abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Faf2^tm1Tfji/Faf2^tm1Tfji,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * DBA
MP:0002493	increased IgG	"greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0002494	increased IgM	"greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0002576	abnormal enamel morphology	"malformation of the hard outer coating of the exposed portion of the tooth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:71126, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0002628	fatty liver	"an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺,Ikbkb^tm2Mka/Ikbkb^tm2Mka Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6 Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Lep^ob/Lep^ob,Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: B6.Cg-Nfe2l2^tm1Mym Lep^ob
MP:0002640	reticulocytosis	"an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Slc5a3^tm1Gtb/Slc5a3⁺ Genetic Background: involves: 129X1/SvJ
MP:0002642	anisocytosis	"blood cells of variable size on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Slc5a3^tm1Gtb/Slc5a3⁺ Genetic Background: involves: 129X1/SvJ
MP:0002643	poikilocytosis	"blood cells of variable shape on smear" [J:7209, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]	Show Allelic Composition: Slc5a3^tm1Gtb/Slc5a3⁺ Genetic Background: involves: 129X1/SvJ
MP:0002654	spongiform encephalopathy	"a neurodegenerative state characterized by the appearance of large vacuolated areas in the brain cells, resembling a sponge" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Slc5a3^tm1Gtb/Slc5a3⁺ Genetic Background: involves: 129X1/SvJ
MP:0002743	glomerulonephritis	"glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0002874	decreased hemoglobin content	"decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Slc5a3^tm1Gtb/Slc5a3⁺ Genetic Background: involves: 129X1/SvJ
MP:0002875	decreased erythrocyte count	"reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Slc5a3^tm1Gtb/Slc5a3⁺ Genetic Background: involves: 129X1/SvJ
MP:0002941	increased circulating alanine transaminase level	"increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym,n-TUtca2^tm2Mym/n-TUtca2^tm2.1Mym,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002944	increased lactate dehydrogenase level	"greater than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87714]	Show Allelic Composition: Slc5a3^tm1Gtb/Slc5a3⁺ Genetic Background: involves: 129X1/SvJ
MP:0002962	increased protein excretion	"greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0003076	increased susceptibility to ischemic brain injury	"increased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [J:90111, smb:Susan M. Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0003103	liver degeneration	"deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym,n-TUtca2^tm2Mym/n-TUtca2^tm2.1Mym,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0003179	decreased platelet count	"fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]	Show Allelic Composition: Nfe2^tm1Sho/Nfe2^tm1Sho,Nfe2l2^tm1Ney/Nfe2l2^tm1Ney Genetic Background: involves: 129/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 Allelic Composition: Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: involves: 129X1/SvJ
MP:0003354	astrocytosis	"a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: involves: 129X1/SvJ
MP:0003402	decreased liver weight	"reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: involves: 129X1/SvJ
MP:0003619	abnormal urine color	"any alteration from the usual straw-coloration of the urine" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Lep^ob/Lep^ob,Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: B6.Cg-Nfe2l2^tm1Mym Lep^ob
MP:0003628	abnormal lymphocyte adhesion	"anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003656	abnormal erythrocyte physiology	"functional anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: involves: 129X1/SvJ
MP:0003668	abnormal periodontal ligament morphology	"any structural anomaly in the fibrous connective tissue that surrounds the root of a tooth, separating it from and attaching it to the alveolar bone; normally extends from the base of the gingival mucosa to the fundus of the bony socket, and its main function is to hold the tooth in its socket" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:66512]	Show Allelic Composition: Faf2^tm1Tfji/Faf2^tm1Tfji,Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * DBA
MP:0003674	oxidative stress	"condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: involves: 129X1/SvJ Allelic Composition: Nfe2l1^tm1Ywk/Nfe2l1^tm1Ywk,Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: involves: 129X1/SvJ Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * ICR Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: B6.129X1-Nfe2l2^tm1Ywk/J
MP:0003871	abnormal myelin sheath morphology	"malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: involves: 129X1/SvJ
MP:0003887	increased hepatocyte apoptosis	"increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym,n-TUtca2^tm2Mym/n-TUtca2^tm2.1Mym,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003984	embryonic growth retardation	"slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nfe2l1^tm1Ywk/Nfe2l1^tm1Ywk,Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: involves: 129X1/SvJ
MP:0004001	decreased hepatocyte proliferation	"reduced growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: involves: 129X1/SvJ
MP:0004499	increased incidence of chemically-induced tumors	"higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0004762	increased anti-double stranded DNA antibody level	"increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0004794	increased anti-nuclear antigen antibody level	"elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0004821	increased susceptibility to experimental autoimmune uveoretinitis	"greater likelihood that an organism will develop disease symptoms similar to human sight-threatening inflammatory eye diseases upon induction by peripheral immunization with one of several uveitogenic retinal proteins (or with peptides derived from them), or by the adoptive transfer of lymphocytes specific to these antigens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004882	enlarged lung	"increased size of the lung compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: involves: 129X1/SvJ
MP:0004924	abnormal behavior	"anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0004952	increased spleen weight	"greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: involves: 129X1/SvJ Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0005018	decreased T cell number	"fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0005088	increased acute inflammation	"greater than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0005150	cachexia	"general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005165	increased susceptibility to injury	"greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Atm^tm1Fwa/Atm^tm1Fwa Genetic Background: involves: 129S4/SvJae
MP:0005264	glomerulosclerosis	"hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0005325	abnormal glomerulus	"anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0005331	insulin resistance	"diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Lep^ob/Lep^ob,Nfe2l2^tm1.1Jgpi/Nfe2l2^tm1.1Jgpi,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: C57BL/6 Allelic Composition: Lep^ob/Lep^ob,Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: B6.Cg-Nfe2l2^tm1Mym Lep^ob
MP:0005341	decreased susceptibility to atherosclerosis	"less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
MP:0005344	increased circulating bilirubin level	"greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]	Show Allelic Composition: Slc5a3^tm1Gtb/Slc5a3⁺ Genetic Background: involves: 129X1/SvJ
MP:0005425	increased macrophage count	"greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]	Show Allelic Composition: Slc5a3^tm1Gtb/Slc5a3⁺ Genetic Background: involves: 129X1/SvJ
MP:0005517	decreased liver regeneration	"less than the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Slc5a3^tm1Gtb/Slc5a3⁺ Genetic Background: involves: 129X1/SvJ
MP:0005559	increased circulating glucose level	"greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * C57BL/6J Allelic Composition: Lep^ob/Lep^ob,Nfe2l2^tm1.1Jgpi/Nfe2l2^tm1.1Jgpi,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: C57BL/6
MP:0005630	increased lung weight	"greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0005637	abnormal iron homeostasis	"anomaly in the state of equilibrium in the body with respect to this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64456]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd
MP:0006042	increased apoptosis	"greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym,n-TUtca2^tm2Mym/n-TUtca2^tm2.1Mym,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Nfe2l1^tm1Ywk/Nfe2l1^tm1Ywk,Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: involves: 129X1/SvJ
MP:0006050	pulmonary fibrosis	"formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0006060	increased cerebral infarction size	"increased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0008075	decreased CD4-positive T cell number	"reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0008406	increased cellular sensitivity to hydrogen peroxide	"greater incidence of cell death following exposure to hydrogen peroxide" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym,n-TUtca2^tm2Mym/n-TUtca2^tm2.1Mym,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: involves: 129X1/SvJ
MP:0008412	increased cellular sensitivity to oxidative stress	"greater incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym,n-TUtca2^tm2Mym/n-TUtca2^tm2.1Mym,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2 Allelic Composition: Nfe2l1^tm1Ywk/Nfe2l1^tm1Ywk,Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: involves: 129X1/SvJ
MP:0008537	increased susceptibility to induced colitis	"increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2⁺ Genetic Background: involves: 129P2/OlaHsd
MP:0008553	increased circulating tumor necrosis factor level	"greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008561	decreased tumor necrosis factor secretion	"reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Atm^tm1Fwa/Atm^tm1Fwa Genetic Background: involves: 129S4/SvJae
MP:0008596	increased circulating interleukin-6 level	"increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008641	increased circulating interleukin-1 beta level	"increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]	Show Allelic Composition: Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: involves: 129X1/SvJ
MP:0008642	decreased circulating interleukin-1 beta level	"reduction in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]	Show Allelic Composition: Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: involves: 129X1/SvJ
MP:0008658	decreased interleukin-1 beta secretion	"reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]	Show Allelic Composition: Atm^tm1Fwa/Atm^tm1Fwa Genetic Background: involves: 129S4/SvJae
MP:0008737	abnormal spleen physiology	"any anomaly in the function of the organ that filters blood and stores red corpuscles and platelets" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: involves: 129X1/SvJ
MP:0008770	decreased survivor rate	"a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺,Ikbkb^tm2Mka/Ikbkb^tm2Mka Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
MP:0008807	increased liver iron level	"increase in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd
MP:0008872	abnormal response to xenobiotics	"any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * ICR Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008873	increased sensitivity to xenobiotics	"decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: involves: 129X1/SvJ
MP:0008875	abnormal pharmacokinetics of xenobiotics	"any anomaly in the absorbtion, distribution, metabolism or elimination of a foreign compound" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺,Ikbkb^tm2Mka/Ikbkb^tm2Mka Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6
MP:0009117	abnormal white fat cell morphology	"any structural anomaly of fat cells with light coloration and few mitochondria; these contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole" [MESH:A11.329.114.500]	Show Allelic Composition: Lep^ob/Lep^ob,Nfe2l2^tm1.1Jgpi/Nfe2l2^tm1.1Jgpi,Tg(Fabp4-cre)1Rev/0 Genetic Background: involves: C57BL/6 Allelic Composition: Lep^ob/Lep^ob,Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: B6.Cg-Nfe2l2^tm1Mym Lep^ob
MP:0009322	increased splenocyte apoptosis	"increase in the number of spleen cells undergoing programmed cell death" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: involves: 129X1/SvJ
MP:0009333	abnormal splenocyte physiology	"any functional anomaly of a cell of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: involves: 129X1/SvJ
MP:0009356	decreased liver triglyceride level	"lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lep^ob/Lep^ob,Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: B6.Cg-Nfe2l2^tm1Mym Lep^ob
MP:0009766	increased sensitivity to xenobiotic induced morbidity/mortality	"decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: involves: 129X1/SvJ Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010096	abnormal incisor color	"anomaly in the color and shading of the incisor, which normally presents in shades of white" [PMID:12407097]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd
MP:0010177	acanthocytosis	"presence of erythrocytes characterized by multiple spiny (thorn-like) cytoplasmic projections" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: involves: 129X1/SvJ
MP:0010178	increased number of Howell-Jolly bodies	"abnormal presence of basophilic nuclear remnants of condensed DNA (1 to 2 um in diameter) in circulating erythrocytes, typically seen in severe hemolytic anemias or after splenectomy; these inclusions are normally removed by the spleen but will persist in individuals with functional hyposplenia or asplenia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: involves: 129X1/SvJ
MP:0010182	decreased susceptibility to weight gain	"smaller increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lep^ob/Lep^ob,Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: B6.Cg-Nfe2l2^tm1Mym Lep^ob
MP:0010301	increased stomach tumor incidence	"greater than the expected number of neoplasms in the gastric tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0011084	partial lethality at weaning	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at weaning age" [MGI:csmith]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym,n-TUtca2^tm2Mym/n-TUtca2^tm2.1Mym,Lyz2^tm1(cre)Ifo/Lyz2⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Ahr^tm1Yfk/Ahr^tm1Yfk,Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J * ICR
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Nfe2l1^tm1Ywk/Nfe2l1^tm1Ywk,Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: involves: 129X1/SvJ
MP:0011167	abnormal adipose tissue development	"anomaly in the process of the formation of the connective tissue composed of fat cells enmeshed in areolar tissue" [MESH:A10.165.114, MGI:csmith]	Show Allelic Composition: Lep^ob/Lep^ob,Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: B6.Cg-Nfe2l2^tm1Mym Lep^ob
MP:0011320	abnormal glomerular capillary morphology	"any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0011339	abnormal glomerular mesangium morphology	"any structural anomaly of the inner layer of the glomerulus within the basement membrane surrounding the glomerular capillaries that contain the intraglomerular mesangial cells" [MGI:csmith]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0011427	mesangial cell hyperplasia	"increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft" [MGI:anna]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0011440	increased kidney cell proliferation	"increase in the expansion rate of any kidney cell population by cell division" [MGI:anna]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0011471	decreased urine creatinine level	"a reduced amount of creatinine in the urine compared to the normal state" [MGI:csmith]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0011506	glomerular crescent	"formation of a crescent-shaped (semi-lunar) glomerular lesion corresponding to extracapillary proliferation of Bowman s capsular epithelium and acquiring a fibroblast-like spindled morphology, possibly stimulated by release of fibrinogen from a ruptured glomerular basement membrane; epithelial crescents occur in aggressive forms of glomerulonephritis, may be accompanied by collagen and fibrin deposition and/or monocyte and macrophage proliferation, may protrude into Bowman s space, and ultimately compress and destroy the glomerular tuft" [MGI:anna]	Show Allelic Composition: Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: involves: 129P2/OlaHsd * ICR
MP:0011940	decreased food intake	"reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Lep^ob/Lep^ob,Nfe2l2^tm1Mym/Nfe2l2^tm1Mym Genetic Background: B6.Cg-Nfe2l2^tm1Mym Lep^ob
MP:0012652	decreased catalase level		Show Allelic Composition: Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: B6.129X1-Nfe2l2^tm1Ywk/J
MP:0013501	increased fibroblast apoptosis	"increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]	Show Allelic Composition: Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: involves: 129X1/SvJ Allelic Composition: Nfe2l1^tm1Ywk/Nfe2l1^tm1Ywk,Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: involves: 129X1/SvJ
MP:0030466	alveolar process atrophy	"acquired diminution of the size of the alveolar process associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]	Show Allelic Composition: Nfe2l2^tm1Ywk/Nfe2l2^tm1Ywk Genetic Background: B6.129X1-Nfe2l2^tm1Ywk/J

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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