ENSMUSG00000058794


Mus musculus

Features
Gene ID: ENSMUSG00000058794
  
Biological name :Nfe2
  
Synonyms : Nfe2 / nuclear factor, erythroid 2
  
Possible biological names infered from orthology : Q16621
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F3
Gene start: 103248212
Gene end: 103258403
  
Corresponding Affymetrix probe sets: 10433096 (MoGene1.0st)   1452001_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116079
Ensembl peptide - ENSMUSP00000123064
Ensembl peptide - ENSMUSP00000122476
Ensembl peptide - ENSMUSP00000121817
Ensembl peptide - ENSMUSP00000120256
Ensembl peptide - ENSMUSP00000117474
Ensembl peptide - ENSMUSP00000116678
Ensembl peptide - ENSMUSP00000116158
Ensembl peptide - ENSMUSP00000074684
Ensembl peptide - ENSMUSP00000114160
NCBI entrez gene - 18022     See in Manteia.
MGI - MGI:97308
RefSeq - XM_006520573
RefSeq - NM_001302338
RefSeq - NM_001302339
RefSeq - NM_001302340
RefSeq - NM_001302341
RefSeq - NM_001302343
RefSeq - NM_008685
RefSeq - XM_006520569
RefSeq Peptide - NP_001289269
RefSeq Peptide - NP_001289270
RefSeq Peptide - NP_001289272
RefSeq Peptide - NP_032711
RefSeq Peptide - NP_001289267
RefSeq Peptide - NP_001289268
swissprot - D3Z4E8
swissprot - D3Z224
swissprot - D3Z0J1
swissprot - D3YUM3
swissprot - A0A0R4J0Y5
swissprot - D3Z706
swissprot - D3Z6L9
Ensembl - ENSMUSG00000058794
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfe2ENSDARG00000020606Danio rerio
 NFE2ENSG00000123405Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nfe2l1 / Q61985 / Nuclear factor erythroid 2-related factor 1 / Q14494* / nuclear factor, erythroid 2 like 1*ENSMUSG0000003861536
Nfe2l2 / Q60795 / Nuclear factor erythroid 2-related factor 2 / Q16236* / nuclear factor, erythroid 2 like 2*ENSMUSG0000001583935
Nfe2l3 / Q9WTM4 / nuclear factor, erythroid derived 2, like 3 / Q9Y4A8* / nuclear factor, erythroid 2 like 3*ENSMUSG0000002983230
Bach1 / P97302 / Transcription regulator protein BACH1 / O14867* / BTB domain and CNC homolog 1*ENSMUSG0000002561221
Bach2 / P97303 / Transcription regulator protein BACH2 / Q9BYV9* / BTB domain and CNC homolog 2*ENSMUSG0000004027018


Protein motifs (from Interpro)
Interpro ID Name
 IPR004826  Basic leucine zipper domain, Maf-type
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR029853  Transcription factor NF-E2, 45kDa subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0032993 protein-DNA complex IEA
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA
 molecular_functionGO:0050699 WW domain binding IEA


Pathways (from Reactome)
Pathway description
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Myo5argsc152/Myo5argsc152
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Nfe2tm1Sho/Nfe2tm1Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001545 abnormal hematopoietic system physiology "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myo5argsc152/Myo5argsc152
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Nfe2tm1Sho/Nfe2tm1Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Myo5argsc152/Myo5argsc152
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Nfe2tm1Sho/Nfe2tm1Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Nfe2tm1Sho/Nfe2tm1Sho,Nfe2l2tm1Ney/Nfe2l2tm1Ney
Genetic Background: involves: 129/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
Show

Allelic Composition: Myo5argsc152/Myo5argsc152
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Nfe2tm1Sho/Nfe2tm1Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002021 increased incidence of induced tumors "higher than normal frequency of tumor incidence induced by a carcinogen or mutagen" [J:44427]
Show

Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfe2l2tm1Ney/Nfe2l2tm1Ney,Nfe2l3tm1Vbl/Nfe2l3tm1Vbl
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myo5argsc152/Myo5argsc152
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Nfe2tm1Sho/Nfe2tm1Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae

 MP:0002813 microcytosis "the presence of unusually small erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Myo5argsc152/Myo5argsc152
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Nfe2tm1Sho/Nfe2tm1Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myo5argsc152/Myo5argsc152
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Nfe2tm1Sho/Nfe2tm1Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Myo5argsc152/Myo5argsc152
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Nfe2tm1Sho/Nfe2tm1Sho,Nfe2l2tm1Ney/Nfe2l2tm1Ney
Genetic Background: involves: 129/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0003714 absence of platelets "lack of non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myo5argsc152/Myo5argsc152
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Nfe2tm1Sho/Nfe2tm1Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Myo5argsc152/Myo5argsc152
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Nfe2tm1Sho/Nfe2tm1Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo5argsc152/Myo5argsc152
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0004988 increased osteoblast cell number "greater than average number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo5argsc152/Myo5argsc152
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
Show

Allelic Composition: Myo5argsc152/Myo5argsc152
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Nfe2tm1Sho/Nfe2tm1Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo5argsc152/Myo5argsc152
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Nfe2tm1Sho/Nfe2tm1Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gata1tm2Sho/Gata1tm2Sho
Genetic Background: involves: 129S4/SvJae

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo5argsc152/Myo5argsc152
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0010961 increased compact bone mass 
Show

Allelic Composition: Myo5argsc152/Myo5argsc152
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Myo5argsc152/Myo5argsc152
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Myo5argsc152/Myo5argsc152
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Nfe2tm1Sho/Nfe2tm1Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0020039 increased bone ossification "increase in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Myo5argsc152/Myo5argsc152
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0020399 enhanced megakaryocyte emperipolesis "an increase in the process by which a a megakaryocyte is penetrated by another living cell" [PMID:25654060, PMID:26950939]
Show

Allelic Composition: Nfe2tm1Sho/Nfe2tm1Sho
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr