ENSMUSG00000025612


Mus musculus

Features
Gene ID: ENSMUSG00000025612
  
Biological name :Bach1
  
Synonyms : Bach1 / P97302 / Transcription regulator protein BACH1
  
Possible biological names infered from orthology : BTB domain and CNC homolog 1 / O14867
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: C3.3
Gene start: 87698945
Gene end: 87733346
  
Corresponding Affymetrix probe sets: 10436734 (MoGene1.0st)   1440831_at (Mouse Genome 430 2.0 Array)   1449311_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026703
NCBI entrez gene - 12013     See in Manteia.
MGI - MGI:894680
RefSeq - XM_006522879
RefSeq - NM_007520
RefSeq Peptide - NP_031546
swissprot - P97302
swissprot - Q3URL4
Ensembl - ENSMUSG00000025612
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bach1aENSDARG00000062553Danio rerio
 bach1bENSDARG00000002196Danio rerio
 BACH1ENSGALG00000015828Gallus gallus
 BACH1ENSG00000156273Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bach2 / P97303 / Transcription regulator protein BACH2 / Q9BYV9* / BTB domain and CNC homolog 2*ENSMUSG0000004027036
Nfe2l1 / Q61985 / Nuclear factor erythroid 2-related factor 1 / Q14494* / nuclear factor, erythroid 2 like 1*ENSMUSG0000003861515
Nfe2l2 / Q60795 / Nuclear factor erythroid 2-related factor 2 / Q16236* / nuclear factor, erythroid 2 like 2*ENSMUSG0000001583913
Nfe2l3 / Q9WTM4 / nuclear factor, erythroid derived 2, like 3 / Q9Y4A8* / nuclear factor, erythroid 2 like 3*ENSMUSG0000002983213
Nfe2 / nuclear factor, erythroid 2 / Q16621*ENSMUSG0000005879410


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR004826  Basic leucine zipper domain, Maf-type
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR011333  SKP1/BTB/POZ domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle IEA
 biological_processGO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle IEA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0031463 Cul3-RING ubiquitin ligase complex IBA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fn1tm2Bwg/Fn1tm2Bwg
Genetic Background: involves: 129S4/SvJae

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lhx8tm1Awan/Lhx8tm1Awan
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003223 decreased cardiomyocyte apoptosis "decrease in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Fn1tm2Bwg/Fn1tm2Bwg
Genetic Background: involves: 129S4/SvJae

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fn1tm2Bwg/Fn1tm2Bwg
Genetic Background: involves: 129S4/SvJae

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fn1tm2Bwg/Fn1tm2Bwg
Genetic Background: involves: 129S4/SvJae

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ahrrtm1b(KOMP)Wtsi/Ahrrtm1b(KOMP)Wtsi
Genetic Background: B6N(Cg)-Ahrrtm1b(KOMP)Wtsi/J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ahrrtm1b(KOMP)Wtsi/Ahrrtm1b(KOMP)Wtsi
Genetic Background: B6N(Cg)-Ahrrtm1b(KOMP)Wtsi/J

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Ahrrtm1b(KOMP)Wtsi/Ahrrtm1b(KOMP)Wtsi
Genetic Background: B6N(Cg)-Ahrrtm1b(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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