ENSDARG00000020606


Danio rerio

Features
Gene ID: ENSDARG00000020606
  
Biological name :nfe2
  
Synonyms : nfe2 / nuclear factor, erythroid 2
  
Possible biological names infered from orthology : Q16621
  
Species: Danio rerio
  
Chr. number: 23
Strand: -1
Band:
Gene start: 36311581
Gene end: 36316352
  
Corresponding Affymetrix probe sets: Dr.20046.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000002745
Ensembl peptide - ENSDARP00000105608
NCBI entrez gene - 317765     See in Manteia.
swissprot - B3DG00
swissprot - F1QWY1
ZFIN ID - ZDB-GENE-030124-1
Ensembl - ENSDARG00000020606
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NFE2ENSG00000123405Homo sapiens
 Nfe2ENSMUSG00000058794Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
nfe2l2a / nuclear factor, erythroid 2-like 2a / NFE2L2* / Q16236* / Q60795* / nuclear factor, erythroid 2 like 2* / Nuclear factor erythroid 2-related factor 2 *ENSDARG0000004282426
nfe2l3 / nuclear factor, erythroid 2-like 3 / Q9Y4A8*ENSDARG0000001981021
nfe2l1a / nuclear factor, erythroid 2-like 1a / NFE2L1* / Q14494* / Q61985* / nuclear factor, erythroid 2 like 1* / Nuclear factor erythroid 2-related factor 1 *ENSDARG0000003061621
nfe2l2b / nuclear factor, erythroid 2-like 2bENSDARG0000008969716
bach2a / BTB and CNC homology 1, basic leucine zipper transcription factor 2a / BACH2* / P97303* / Q9BYV9* / BTB domain and CNC homolog 2* / Transcription regulator protein BACH2 *ENSDARG0000003656915
bach1b / BTB and CNC homology 1, basic leucine zipper transcription factor 1 b / BACH1* / O14867* / BTB domain and CNC homolog 1*ENSDARG0000000219614
bach2b / BTB and CNC homology 1, basic leucine zipper transcription factor 2b / BACH2* / P97303* / Q9BYV9* / BTB domain and CNC homolog 2* / Transcription regulator protein BACH2 *ENSDARG0000000407413
bach1a / BTB and CNC homology 1, basic leucine zipper transcription factor 1 a / BACH1* / O14867* / P97302* / BTB domain and CNC homolog 1* / Transcription regulator protein BACH1 *ENSDARG0000006255312


Protein motifs (from Interpro)
Interpro ID Name
 IPR004826  Basic leucine zipper domain, Maf-type
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR029847  Nuclear factor erythroid 2-related factor 1/NFE2L1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IC
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0010725 regulation of primitive erythrocyte differentiation IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IBA
 biological_processGO:0048798 swim bladder inflation IMP
 biological_processGO:0071600 otic vesicle morphogenesis IMP
 biological_processGO:1902882 regulation of response to oxidative stress IMP
 cellular_componentGO:0005634 nucleus IC
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IPI
 molecular_functionGO:0003700 DNA-binding transcription factor activity IBA
 molecular_functionGO:0043565 sequence-specific DNA binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000076 swim bladder swim bladder uninflated , abnormal
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 ZFA:0000204 esophagus esophagus muscle decreased size , abnormal
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 ZFA:0000354 gill gill morphology , abnormal
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 ZFA:0000530 lapillus lapillus mislocalised , abnormal
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 ZFA:0000676 sagitta sagitta mislocalised , abnormal
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 ZFA:0001094 whole organism whole organism increased amount , abnormal
whole organism decreased amount , abnormal
whole organism anterior-posterior axis increased curvature , abnormal
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 ZFA:0001306 pharyngeal arch pharyngeal arch morphology , abnormal
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 ZFA:0001430 pneumatic duct pneumatic duct epithelium morphology , abnormal
pneumatic duct epithelial cell disoriented , abnormal
pneumatic duct epithelial cell increased variability of size , abnormal
pneumatic duct epithelial cell decreased amount , abnormal
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 ZFA:0001499 esophageal epithelium esophageal epithelium mucus secreting cell decreased amount , abnormal
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 ZFA:0001617 otolith otolith mislocalised , abnormal
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 ZFA:0001715 otic vesicle protrusion otic vesicle protrusion absent , abnormal
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte low saturation , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000028957 maff / v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F / O54791* / Q9ULX9* / Transcription factor MafF * / MAF bZIP transcription factor F*  / complex
 ENSDARG00000018109 mafga / v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Ga / MAFG* / O15525* / O54790* / Transcription factor MafG * / MAF bZIP transcription factor G*  / complex
 ENSDARG00000100097 mafgb / v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Gb / MAFG* / O15525* / O54790* / Transcription factor MafG * / MAF bZIP transcription factor G*  / complex
 ENSDARG00000100947 mafk / v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K / O60675* / Q61827* / MAF bZIP transcription factor K* / v-maf musculoaponeurotic fibrosarcoma oncogene family, protein...  / complex






 

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