ENSG00000185022


Homo sapiens

Features
Gene ID: ENSG00000185022
  
Biological name :MAFF
  
Synonyms : MAF bZIP transcription factor F / MAFF / Q9ULX9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q13.1
Gene start: 38200767
Gene end: 38216511
  
Corresponding Affymetrix probe sets: 205193_at (Human Genome U133 Plus 2.0 Array)   36711_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000391589
Ensembl peptide - ENSP00000442060
Ensembl peptide - ENSP00000441482
Ensembl peptide - ENSP00000416493
Ensembl peptide - ENSP00000345393
Ensembl peptide - ENSP00000384094
Ensembl peptide - ENSP00000388882
NCBI entrez gene - 23764     See in Manteia.
OMIM - 604877
RefSeq - NM_001161574
RefSeq - NM_012323
RefSeq - NM_001161572
RefSeq - NM_001161573
RefSeq Peptide - NP_001155045
RefSeq Peptide - NP_036455
RefSeq Peptide - NP_001155044
RefSeq Peptide - NP_001155046
swissprot - Q9ULX9
swissprot - B0QY70
swissprot - B0QY71
Ensembl - ENSG00000185022
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 maffENSDARG00000028957Danio rerio
 MAFFENSGALG00000012277Gallus gallus
 MaffENSMUSG00000042622Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAFK / O60675 / MAF bZIP transcription factor KENSG0000019851762
MAFG / O15525 / MAF bZIP transcription factor GENSG0000019706360
MAF / O75444 / MAF bZIP transcription factorENSG0000017857339
MAFB / Q9Y5Q3 / MAF bZIP transcription factor BENSG0000020410339
MAFA / Q8NHW3 / MAF bZIP transcription factor AENSG0000018275937
NRL / P54845 / neural retina leucine zipperENSG0000012953534


Protein motifs (from Interpro)
Interpro ID Name
 IPR004826  Basic leucine zipper domain, Maf-type
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR024874  Transcription factor Maf family
 IPR033531  Transcription factor MafF


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0007567 parturition TAS
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0035914 skeletal muscle cell differentiation IEA
 biological_processGO:0045604 regulation of epidermal cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005739 mitochondrion IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000123405 NFE2 / Q16621 / nuclear factor, erythroid 2  / reaction / complex






 

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