ENSDARG00000043531


Danio rerio

Features
Gene ID: ENSDARG00000043531
  
Biological name :jun
  
Synonyms : jun / Jun proto-oncogene, AP-1 transcription factor subunit
  
Possible biological names infered from orthology : jun proto-oncogene / P05412 / P05627
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 15552657
Gene end: 15554606
  
Corresponding Affymetrix probe sets: Dr.7608.1.A1_at (Zebrafish Array)   Dr.7608.2.S1_at (Zebrafish Array)   NM_199987_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000063911
NCBI entrez gene - 335916     See in Manteia.
RefSeq - NM_199987
RefSeq Peptide - NP_956281
swissprot - Q6NZT5
ZFIN ID - ZDB-GENE-030131-7859
Ensembl - ENSDARG00000043531
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 JUNENSGALG00000010870Gallus gallus
 JUNENSG00000177606Homo sapiens
 JunENSMUSG00000052684Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
junba / JunB proto-oncogene, AP-1 transcription factor subunit a / JUNB* / P09450* / P17275* / Transcription factor jun-B * / JunB proto-oncogene, AP-1 transcription factor subunit*ENSDARG0000007437851
junbb / JunB proto-oncogene, AP-1 transcription factor subunit b / JUNB* / P09450* / P17275* / Transcription factor jun-B * / JunB proto-oncogene, AP-1 transcription factor subunit*ENSDARG0000010477349
jund / JunD proto-oncogene, AP-1 transcription factor subunit / P15066* / P17535* / Transcription factor jun-D *ENSDARG0000006785049
june / JunE proto-oncogene, AP-1 transcription factor subunitENSDARG0000010409046


Protein motifs (from Interpro)
Interpro ID Name
 IPR002112  Transcription factor Jun
 IPR004827  Basic-leucine zipper domain
 IPR005643  Jun-like transcription factor
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR015558  Transcription Factor c-Jun/v-Jun


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007420 brain development IGI
 biological_processGO:0009314 response to radiation IBA
 biological_processGO:0009612 response to mechanical stimulus IBA
 biological_processGO:0010941 regulation of cell death IBA
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:0034097 response to cytokine IBA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042493 response to drug IBA
 biological_processGO:0045597 positive regulation of cell differentiation IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0046686 response to cadmium ion IEP
 biological_processGO:0051591 response to cAMP IBA
 biological_processGO:0051597 response to methylmercury IDA
 biological_processGO:0051726 regulation of cell cycle IBA
 biological_processGO:0060070 canonical Wnt signaling pathway IMP
 cellular_componentGO:0000790 nuclear chromatin IBA
 cellular_componentGO:0005667 transcription factor complex IMP
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IMP
 molecular_functionGO:0003713 transcription coactivator activity IBA
 molecular_functionGO:0008013 beta-catenin binding IMP
 molecular_functionGO:0008134 transcription factor binding IBA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
Activation of the AP-1 family of transcription factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000079 telencephalon telencephalon increased size , abnormal
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 ZFA:0001094 whole organism whole organism wholly anterioralized , abnormal
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 ZFA:0001114 head head increased size , abnormal
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 ZFA:0001117 post-vent region post-vent region decreased size , abnormal
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 ZFA:0009065 endothelial cell endothelial cell apoptotic process increased occurrence , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000031683 fosab / v-fos FBJ murine osteosarcoma viral oncogene homolog Ab / FOS* / P01100* / P01101* / Proto-onco c-Fos * / Fos proto-oncogene, AP-1 transcription factor subunit*  / complex / reaction
 ENSDARG00000023903 atf2 / activating transcription factor 2 / P15336* / P16951* / Cyclic AMP-dependent transcription factor ATF-2 *  / reaction / complex
 ENSDARG00000077364 mapk9 / mitogen-activated protein kinase 9 / P45984* / Q9WTU6*  / reaction






 

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