ENSG00000115966


Homo sapiens

Features
Gene ID: ENSG00000115966
  
Biological name :ATF2
  
Synonyms : activating transcription factor 2 / ATF2 / P15336
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q31.1
Gene start: 175072250
Gene end: 175168382
  
Corresponding Affymetrix probe sets: 1555146_at (Human Genome U133 Plus 2.0 Array)   205446_s_at (Human Genome U133 Plus 2.0 Array)   212984_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000410086
Ensembl peptide - ENSP00000410224
Ensembl peptide - ENSP00000437952
Ensembl peptide - ENSP00000416854
Ensembl peptide - ENSP00000414171
Ensembl peptide - ENSP00000412293
Ensembl peptide - ENSP00000264110
Ensembl peptide - ENSP00000340576
Ensembl peptide - ENSP00000376327
Ensembl peptide - ENSP00000386282
Ensembl peptide - ENSP00000386326
Ensembl peptide - ENSP00000386526
Ensembl peptide - ENSP00000387093
Ensembl peptide - ENSP00000389504
Ensembl peptide - ENSP00000402190
Ensembl peptide - ENSP00000402229
Ensembl peptide - ENSP00000406995
Ensembl peptide - ENSP00000407911
NCBI entrez gene - 1386     See in Manteia.
OMIM - 123811
RefSeq - NM_001880
RefSeq - NM_001256090
RefSeq - NM_001256091
RefSeq - NM_001256092
RefSeq - NM_001256093
RefSeq - NM_001256094
RefSeq Peptide - NP_001871
RefSeq Peptide - NP_001243019
RefSeq Peptide - NP_001243020
RefSeq Peptide - NP_001243021
RefSeq Peptide - NP_001243022
RefSeq Peptide - NP_001243023
swissprot - P15336
swissprot - E9PBF9
swissprot - C9JCI8
swissprot - B8ZZU6
swissprot - F2Z2K2
swissprot - F5H629
swissprot - H7C2N6
swissprot - E9PEK8
Ensembl - ENSG00000115966
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atf2ENSDARG00000023903Danio rerio
 ATF2ENSGALG00000009287Gallus gallus
 Atf2ENSMUSG00000027104Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ATF7 / P17544 / activating transcription factor 7ENSG0000017065354
AC023509.3ENSG0000026728148
CREB5 / Q02930 / cAMP responsive element binding protein 5ENSG0000014659243


Protein motifs (from Interpro)
Interpro ID Name
 IPR004827  Basic-leucine zipper domain
 IPR013087  Zinc finger C2H2-type
 IPR016378  Transcription factor cyclic AMP-dependent, CRE-BP1-type
 IPR029836  cAMP-dependent transcription factor ATF-2
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0003151 outflow tract morphogenesis IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006970 response to osmotic stress IDA
 biological_processGO:0006974 cellular response to DNA damage stimulus IMP
 biological_processGO:0009414 response to water deprivation IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0016525 negative regulation of angiogenesis IMP
 biological_processGO:0016573 histone acetylation IEA
 biological_processGO:0031573 intra-S DNA damage checkpoint IMP
 biological_processGO:0032915 positive regulation of transforming growth factor beta2 production IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0045444 fat cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IEA
 biological_processGO:0051090 regulation of DNA-binding transcription factor activity TAS
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IMP
 biological_processGO:0060612 adipose tissue development IEA
 biological_processGO:0097186 amelogenesis IEA
 biological_processGO:0110024 positive regulation of cardiac muscle myoblast proliferation IDA
 biological_processGO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0035861 site of double-strand break IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001076 transcription factor activity, RNA polymerase II transcription factor binding IC
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001102 RNA polymerase II activating transcription factor binding IPI
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IC
 molecular_functionGO:0003713 transcription coactivator activity TAS
 molecular_functionGO:0004402 histone acetyltransferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008140 cAMP response element binding protein binding IDA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0035497 cAMP response element binding IDA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Transcriptional activation of mitochondrial biogenesis
HATs acetylate histones
Circadian Clock
Activation of the AP-1 family of transcription factors
TP53 Regulates Transcription of DNA Repair Genes
Regulation of PTEN gene transcription
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000112062 MAPK14 / Q16539 / mitogen-activated protein kinase 14  / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction
 ENSG00000091831 ESR1 / P03372 / estrogen receptor 1  / complex
 ENSG00000196890 Q8N257 / HIST3H2BB / histone cluster 3 H2B family member b  / reaction
 ENSG00000203814 Q5QNW6 / HIST2H2BF / histone cluster 2 H2B family member f  / reaction
 ENSG00000184678 Q16778 / HIST2H2BE / histone cluster 2 H2B family member e  / reaction
 ENSG00000109339 MAPK10 / P53779 / mitogen-activated protein kinase 10  / reaction
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction / complex
 ENSG00000050748 MAPK9 / P45984 / mitogen-activated protein kinase 9  / reaction
 ENSG00000185386 MAPK11 / Q15759 / mitogen-activated protein kinase 11  / reaction
 ENSG00000107643 MAPK8 / P45983 / mitogen-activated protein kinase 8  / reaction
 ENSG00000177606 JUN / P05412 / Jun proto-oncogene, AP-1 transcription factor subunit  / reaction / complex






 

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