ENSG00000112062


Homo sapiens

Features
Gene ID: ENSG00000112062
  
Biological name :MAPK14
  
Synonyms : MAPK14 / mitogen-activated protein kinase 14 / Q16539
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p21.31
Gene start: 36027677
Gene end: 36111236
  
Corresponding Affymetrix probe sets: 202530_at (Human Genome U133 Plus 2.0 Array)   210449_x_at (Human Genome U133 Plus 2.0 Array)   211087_x_at (Human Genome U133 Plus 2.0 Array)   211561_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000417065
Ensembl peptide - ENSP00000308669
Ensembl peptide - ENSP00000417531
Ensembl peptide - ENSP00000478079
Ensembl peptide - ENSP00000419837
Ensembl peptide - ENSP00000419141
Ensembl peptide - ENSP00000229794
Ensembl peptide - ENSP00000229795
NCBI entrez gene - 1432     See in Manteia.
OMIM - 600289
RefSeq - XM_017010304
RefSeq - NM_001315
RefSeq - NM_139012
RefSeq - NM_139013
RefSeq - NM_139014
RefSeq - XM_006714998
RefSeq - XM_011514310
RefSeq - XM_017010299
RefSeq - XM_017010300
RefSeq - XM_017010301
RefSeq - XM_017010302
RefSeq - XM_017010303
RefSeq Peptide - NP_620581
RefSeq Peptide - NP_620582
RefSeq Peptide - NP_620583
RefSeq Peptide - NP_001306
swissprot - L7RSM2
swissprot - A0A024RD15
swissprot - E7EX54
swissprot - Q16539
swissprot - B5TY33
swissprot - B4E0K5
swissprot - H7C4E2
Ensembl - ENSG00000112062
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapk14bENSDARG00000028721Danio rerio
 Q9DGE2ENSDARG00000000857Danio rerio
 MAPK14ENSGALG00000042833Gallus gallus
 Mapk14ENSMUSG00000053436Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAPK11 / Q15759 / mitogen-activated protein kinase 11ENSG0000018538672
MAPK12 / P53778 / mitogen-activated protein kinase 12ENSG0000018813063
MAPK13 / O15264 / mitogen-activated protein kinase 13ENSG0000015671159
MAPK9 / P45984 / mitogen-activated protein kinase 9ENSG0000005074850
MAPK8 / P45983 / mitogen-activated protein kinase 8ENSG0000010764348
MAPK10 / P53779 / mitogen-activated protein kinase 10ENSG0000010933948


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR003527  Mitogen-activated protein (MAP) kinase, conserved site
 IPR008352  Mitogen-activated protein (MAP) kinase p38-like
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000077 DNA damage checkpoint IEA
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000187 activation of MAPK activity TAS
 biological_processGO:0000902 cell morphogenesis IEA
 biological_processGO:0001502 cartilage condensation IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001890 placenta development IEA
 biological_processGO:0002062 chondrocyte differentiation IEA
 biological_processGO:0002741 positive regulation of cytokine secretion involved in immune response IEA
 biological_processGO:0006006 glucose metabolic process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II ISS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway IEA
 biological_processGO:0007265 Ras protein signal transduction TAS
 biological_processGO:0007519 skeletal muscle tissue development IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010759 positive regulation of macrophage chemotaxis IEA
 biological_processGO:0010831 positive regulation of myotube differentiation ISS
 biological_processGO:0014835 myoblast differentiation involved in skeletal muscle regeneration IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation ISS
 biological_processGO:0019395 fatty acid oxidation IEA
 biological_processGO:0030278 regulation of ossification IEA
 biological_processGO:0030316 osteoclast differentiation ISS
 biological_processGO:0031281 positive regulation of cyclase activity IMP
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032495 response to muramyl dipeptide IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IMP
 biological_processGO:0035994 response to muscle stretch IEA
 biological_processGO:0038066 p38MAPK cascade ISS
 biological_processGO:0042307 positive regulation of protein import into nucleus IEA
 biological_processGO:0042770 signal transduction in response to DNA damage IMP
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IMP
 biological_processGO:0045663 positive regulation of myoblast differentiation ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046326 positive regulation of glucose import IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IMP
 biological_processGO:0051090 regulation of DNA-binding transcription factor activity TAS
 biological_processGO:0051146 striated muscle cell differentiation IEA
 biological_processGO:0051149 positive regulation of muscle cell differentiation TAS
 biological_processGO:0060045 positive regulation of cardiac muscle cell proliferation IEA
 biological_processGO:0070935 3"-UTR-mediated mRNA stabilization TAS
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:0071223 cellular response to lipoteichoic acid IMP
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071479 cellular response to ionizing radiation IMP
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0090336 positive regulation of brown fat cell differentiation IEA
 biological_processGO:0090400 stress-induced premature senescence IMP
 biological_processGO:0098586 cellular response to virus IMP
 biological_processGO:1900015 regulation of cytokine production involved in inflammatory response IDA
 biological_processGO:1901741 positive regulation of myoblast fusion ISS
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 biological_processGO:1905050 positive regulation of metallopeptidase activity IEA
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IMP
 biological_processGO:2001184 positive regulation of interleukin-12 secretion IMP
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016607 nuclear speck IDA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1904813 ficolin-1-rich granule lumen TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004707 MAP kinase activity IEA
 molecular_functionGO:0004708 MAP kinase kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019903 protein phosphatase binding IPI
 molecular_functionGO:0048273 mitogen-activated protein kinase p38 binding IPI
 molecular_functionGO:0051525 NFAT protein binding ISS


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
p38MAPK events
ERK/MAPK targets
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Oxidative Stress Induced Senescence
CDO in myogenesis
DSCAM interactions
ADP signalling through P2Y purinoceptor 1
Platelet sensitization by LDL
VEGFA-VEGFR2 Pathway
activated TAK1 mediates p38 MAPK activation
Activation of the AP-1 family of transcription factors
KSRP (KHSRP) binds and destabilizes mRNA
Neutrophil degranulation
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000170558 CDH2 / P19022 / cadherin 2  / reaction / complex
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / complex / reaction
 ENSG00000008294 SPAG9 / O60271 / sperm associated antigen 9  / reaction / complex
 ENSG00000129910 CDH15 / P55291 / cadherin 15  / reaction / complex
 ENSG00000064309 CDON / Q4KMG0 / cell adhesion associated, oncogene regulated  / complex / reaction
 ENSG00000081189 MEF2C / Q06413 / myocyte enhancer factor 2C  / complex / reaction
 ENSG00000116711 P47712 / PLA2G4A / phospholipase A2 group IVA  / reaction
 ENSG00000114738 Q16644 / MAPKAPK3 / mitogen-activated protein kinase-activated protein kinase 3  / reaction / complex
 ENSG00000100784 O75582 / RPS6KA5 / ribosomal protein S6 kinase A5  / reaction
 ENSG00000140299 BNIP2 / Q12982 / BCL2 interacting protein 2  / reaction / complex
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / complex / reaction
 ENSG00000066032 CTNNA2 / P26232 / catenin alpha 2  / reaction / complex
 ENSG00000183598 Q71DI3 / HIST2H3D / histone cluster 2 H3 family member d  / reaction
 ENSG00000071564 TCF3 / P15923 / transcription factor 3  / reaction
 ENSG00000097007 ABL1 / P00519 / ABL proto-oncogene 1, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000144857 BOC / Q9BWV1 / BOC cell adhesion associated, oncogene regulated  / complex / reaction
 ENSG00000276180 P62805 / HIST1H4I / histone cluster 1 H4 family member i  / reaction
 ENSG00000109819 Q9UBK2 / PPARGC1A / PPARG coactivator 1 alpha  / reaction
 ENSG00000275714 P68431 / HIST1H3A / histone cluster 1 H3 family member a  / reaction
 ENSG00000044115 CTNNA1 / P35221 / catenin alpha 1  / reaction / complex
 ENSG00000162889 P49137 / MAPKAPK2 / mitogen-activated protein kinase-activated protein kinase 2  / complex / reaction
 ENSG00000088247 KHSRP / Q92945 / KH-type splicing regulatory protein  / reaction
 ENSG00000132475 H3F3B / P84243 / H3 histone family member 3B  / reaction
 ENSG00000068305 MEF2A / Q02078 / myocyte enhancer factor 2A  / reaction / complex
 ENSG00000115966 ATF2 / P15336 / activating transcription factor 2  / reaction
 ENSG00000034152 MAP2K3 / P46734 / mitogen-activated protein kinase kinase 3  / reaction
 ENSG00000108984 MAP2K6 / P52564 / mitogen-activated protein kinase kinase 6  / reaction
 ENSG00000089022 Q8IW41 / MAPKAPK5 / mitogen-activated protein kinase-activated protein kinase 5  / complex






 

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