ENSG00000108984


Homo sapiens

Features
Gene ID: ENSG00000108984
  
Biological name :MAP2K6
  
Synonyms : MAP2K6 / mitogen-activated protein kinase kinase 6 / P52564
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q24.3
Gene start: 69414698
Gene end: 69553861
  
Corresponding Affymetrix probe sets: 205698_s_at (Human Genome U133 Plus 2.0 Array)   205699_at (Human Genome U133 Plus 2.0 Array)   229569_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000466143
Ensembl peptide - ENSP00000464916
Ensembl peptide - ENSP00000467213
Ensembl peptide - ENSP00000477701
Ensembl peptide - ENSP00000468348
Ensembl peptide - ENSP00000351997
NCBI entrez gene - 5608     See in Manteia.
OMIM - 601254
RefSeq - XM_011525027
RefSeq - NM_001330450
RefSeq - NM_002758
RefSeq - XM_005257515
RefSeq - XM_005257516
RefSeq - XM_006721975
RefSeq - XM_011525025
RefSeq - XM_011525026
RefSeq Peptide - NP_002749
RefSeq Peptide - NP_001317379
swissprot - A0A0A0MRF7
swissprot - K7EIW3
swissprot - K7ELM6
swissprot - P52564
swissprot - A0A024R8K3
swissprot - A8K3Y2
Ensembl - ENSG00000108984
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map2k6ENSDARG00000099184Danio rerio
 MAP2K6ENSGALG00000004370Gallus gallus
 Map2k6ENSMUSG00000020623Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAP2K3 / P46734 / mitogen-activated protein kinase kinase 3ENSG0000003415280
MAP2K4 / P45985 / mitogen-activated protein kinase kinase 4ENSG0000006555955
MAP2K7 / O14733 / mitogen-activated protein kinase kinase 7ENSG0000007698445
MAP2K5 / Q13163 / mitogen-activated protein kinase kinase 5ENSG0000013776439
MAP2K2 / P36507 / mitogen-activated protein kinase kinase 2ENSG0000012693437
MAP2K1 / Q02750 / mitogen-activated protein kinase kinase 1ENSG0000016903237
AC011005.1ENSG0000023062635


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000187 activation of MAPK activity TAS
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0002931 response to ischemia IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006975 DNA damage induced protein phosphorylation TAS
 biological_processGO:0007050 cell cycle arrest TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0022602 ovulation cycle process IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0032308 positive regulation of prostaglandin secretion IEA
 biological_processGO:0035897 proteolysis in other organism TAS
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0051770 positive regulation of nitric-oxide synthase biosynthetic process IEA
 biological_processGO:0060048 cardiac muscle contraction IEA
 biological_processGO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS
 biological_processGO:0070498 interleukin-1-mediated signaling pathway TAS
 biological_processGO:0072709 cellular response to sorbitol IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004708 MAP kinase kinase activity TAS
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
Oxidative Stress Induced Senescence
CDO in myogenesis
activated TAK1 mediates p38 MAPK activation
PI5P Regulates TP53 Acetylation
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000185386 MAPK11 / Q15759 / mitogen-activated protein kinase 11  / reaction
 ENSG00000150867 P48426 / PIP4K2A / phosphatidylinositol-5-phosphate 4-kinase type 2 alpha  / reaction
 ENSG00000162889 P49137 / MAPKAPK2 / mitogen-activated protein kinase-activated protein kinase 2  / reaction
 ENSG00000112062 MAPK14 / Q16539 / mitogen-activated protein kinase 14  / reaction
 ENSG00000114738 Q16644 / MAPKAPK3 / mitogen-activated protein kinase-activated protein kinase 3  / reaction
 ENSG00000089022 Q8IW41 / MAPKAPK5 / mitogen-activated protein kinase-activated protein kinase 5  / reaction
 ENSG00000276293 P78356 / PIP4K2B / phosphatidylinositol-5-phosphate 4-kinase type 2 beta  / reaction
 ENSG00000197442 MAP3K5 / Q99683 / mitogen-activated protein kinase kinase kinase 5  / reaction
 ENSG00000135341 MAP3K7 / O43318 / mitogen-activated protein kinase kinase kinase 7  / reaction






 

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