ENSG00000276293


Homo sapiens

Features
Gene ID: ENSG00000276293
  
Biological name :PIP4K2B
  
Synonyms : P78356 / phosphatidylinositol-5-phosphate 4-kinase type 2 beta / PIP4K2B
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q12
Gene start: 38765689
Gene end: 38800126
  
Corresponding Affymetrix probe sets: 1553047_at (Human Genome U133 Plus 2.0 Array)   1553048_a_at (Human Genome U133 Plus 2.0 Array)   201080_at (Human Genome U133 Plus 2.0 Array)   201081_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000482548
Ensembl peptide - ENSP00000477549
NCBI entrez gene - 8396     See in Manteia.
OMIM - 603261
RefSeq - XM_017025199
RefSeq - NM_003559
RefSeq - XM_017025196
RefSeq - XM_017025197
RefSeq - XM_017025198
RefSeq - XM_011525326
RefSeq - XM_011525327
RefSeq - XM_011525330
RefSeq Peptide - NP_003550
swissprot - P78356
swissprot - A0A087WT35
Ensembl - ENSG00000276293
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PIP4K2BENSGALG00000001610Gallus gallus
 Q80XI4ENSMUSG00000018547Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P48426 / PIP4K2A / phosphatidylinositol-5-phosphate 4-kinase type 2 alphaENSG0000015086776
Q8TBX8 / PIP4K2C / phosphatidylinositol-5-phosphate 4-kinase type 2 gammaENSG0000016690864
Q99755 / PIP5K1A / phosphatidylinositol-4-phosphate 5-kinase type 1 alphaENSG0000014339833
O14986 / PIP5K1B / phosphatidylinositol-4-phosphate 5-kinase type 1 betaENSG0000010724231
O60331 / PIP5K1C / phosphatidylinositol-4-phosphate 5-kinase type 1 gammaENSG0000018611131
Q5T9C9 / PIP5KL1 / phosphatidylinositol-4-phosphate 5-kinase like 1ENSG0000016710321


Protein motifs (from Interpro)
Interpro ID Name
 IPR002498  Phosphatidylinositol-4-phosphate 5-kinase, core
 IPR023610  Phosphatidylinositol-4-phosphate 5-kinase
 IPR027483  Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
 IPR027484  Phosphatidylinositol-4-phosphate 5-kinase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006644 phospholipid metabolic process TAS
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0010506 regulation of autophagy IMP
 biological_processGO:0014066 regulation of phosphatidylinositol 3-kinase signaling TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0046488 phosphatidylinositol metabolic process IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:2000786 positive regulation of autophagosome assembly IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005776 autophagosome IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016307 phosphatidylinositol phosphate kinase activity IEA
 molecular_functionGO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity IDA
 molecular_functionGO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0052811 1-phosphatidylinositol-3-phosphate 4-kinase activity TAS


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
PI5P Regulates TP53 Acetylation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Synthesis of PIPs in the nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000127445 PIN1 / Q13526 / peptidylprolyl cis/trans isomerase, NIMA-interacting 1  / complex / reaction
 ENSG00000150867 P48426 / PIP4K2A / phosphatidylinositol-5-phosphate 4-kinase type 2 alpha  / complex
 ENSG00000108984 MAP2K6 / P52564 / mitogen-activated protein kinase kinase 6  / reaction
 ENSG00000166908 Q8TBX8 / PIP4K2C / phosphatidylinositol-5-phosphate 4-kinase type 2 gamma  / complex
 ENSG00000276293 P78356 / PIP4K2B / phosphatidylinositol-5-phosphate 4-kinase type 2 beta  / complex






 

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