ENSG00000166908


Homo sapiens

Features
Gene ID: ENSG00000166908
  
Biological name :PIP4K2C
  
Synonyms : phosphatidylinositol-5-phosphate 4-kinase type 2 gamma / PIP4K2C / Q8TBX8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q13.3
Gene start: 57591174
Gene end: 57603418
  
Corresponding Affymetrix probe sets: 218942_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000450197
Ensembl peptide - ENSP00000449335
Ensembl peptide - ENSP00000449538
Ensembl peptide - ENSP00000347032
Ensembl peptide - ENSP00000412035
Ensembl peptide - ENSP00000439878
Ensembl peptide - ENSP00000447390
Ensembl peptide - ENSP00000448042
NCBI entrez gene - 79837     See in Manteia.
OMIM - 617104
RefSeq - XM_017019973
RefSeq - NM_001146258
RefSeq - NM_001146259
RefSeq - NM_001146260
RefSeq - NM_024779
RefSeq - XM_005269152
RefSeq Peptide - NP_001139731
RefSeq Peptide - NP_001139730
RefSeq Peptide - NP_001139732
RefSeq Peptide - NP_079055
swissprot - H0YIJ6
swissprot - F8VU68
swissprot - F8VNT5
swissprot - Q8TBX8
swissprot - F8VVB2
Ensembl - ENSG00000166908
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pip4k2caENSDARG00000031020Danio rerio
 pip4k2cbENSDARG00000091637Danio rerio
 Q91XU3ENSMUSG00000025417Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P78356 / PIP4K2B / phosphatidylinositol-5-phosphate 4-kinase type 2 betaENSG0000027629364
P48426 / PIP4K2A / phosphatidylinositol-5-phosphate 4-kinase type 2 alphaENSG0000015086762
Q99755 / PIP5K1A / phosphatidylinositol-4-phosphate 5-kinase type 1 alphaENSG0000014339831
O60331 / PIP5K1C / phosphatidylinositol-4-phosphate 5-kinase type 1 gammaENSG0000018611129
O14986 / PIP5K1B / phosphatidylinositol-4-phosphate 5-kinase type 1 betaENSG0000010724229
Q5T9C9 / PIP5KL1 / phosphatidylinositol-4-phosphate 5-kinase like 1ENSG0000016710319


Protein motifs (from Interpro)
Interpro ID Name
 IPR002498  Phosphatidylinositol-4-phosphate 5-kinase, core
 IPR023610  Phosphatidylinositol-4-phosphate 5-kinase
 IPR027483  Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
 IPR027484  Phosphatidylinositol-4-phosphate 5-kinase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0010506 regulation of autophagy IMP
 biological_processGO:0014066 regulation of phosphatidylinositol 3-kinase signaling TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0046488 phosphatidylinositol metabolic process IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:2000786 positive regulation of autophagosome assembly IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005776 autophagosome IMP
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016307 phosphatidylinositol phosphate kinase activity IEA
 molecular_functionGO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity EXP
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
PI5P Regulates TP53 Acetylation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Synthesis of PIPs in the nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000150867 P48426 / PIP4K2A / phosphatidylinositol-5-phosphate 4-kinase type 2 alpha  / complex
 ENSG00000276293 P78356 / PIP4K2B / phosphatidylinositol-5-phosphate 4-kinase type 2 beta  / complex
 ENSG00000166908 Q8TBX8 / PIP4K2C / phosphatidylinositol-5-phosphate 4-kinase type 2 gamma  / complex






 

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