ENSMUSG00000025417


Mus musculus

Features
Gene ID: ENSMUSG00000025417
  
Biological name :Pip4k2c
  
Synonyms : Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma / Pip4k2c / Q91XU3
  
Possible biological names infered from orthology : Q8TBX8
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D3
Gene start: 127197067
Gene end: 127211585
  
Corresponding Affymetrix probe sets: 10373101 (MoGene1.0st)   1416387_at (Mouse Genome 430 2.0 Array)   1416388_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000013970
NCBI entrez gene - 117150     See in Manteia.
MGI - MGI:2152214
RefSeq - XM_017313768
RefSeq - NM_054097
RefSeq - XM_006513121
RefSeq - XM_011243288
RefSeq - XM_011243289
RefSeq - XM_006513120
RefSeq Peptide - NP_473438
RefSeq Peptide - NP_001346209
swissprot - Q91XU3
Ensembl - ENSMUSG00000025417
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pip4k2caENSDARG00000031020Danio rerio
 pip4k2cbENSDARG00000091637Danio rerio
 Q8TBX8ENSG00000166908Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q80XI4 / Pip4k2b / Phosphatidylinositol 5-phosphate 4-kinase type-2 beta / P78356*ENSMUSG0000001854764
O70172 / Pip4k2a / Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha / P48426*ENSMUSG0000002673762
P70182 / Pip5k1a / Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha / Q99755*ENSMUSG0000002812631
O70161 / Pip5k1c / Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma / O60331*ENSMUSG0000003490229
P70181 / Pip5k1b / Phosphatidylinositol 4-phosphate 5-kinase type-1 beta / O14986*ENSMUSG0000002486728
Q6U7H8 / Pip5kl1 / Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 / Q5T9C9* / phosphatidylinositol-4-phosphate 5-kinase like 1*ENSMUSG0000004685419


Protein motifs (from Interpro)
Interpro ID Name
 IPR002498  Phosphatidylinositol-4-phosphate 5-kinase, core
 IPR023610  Phosphatidylinositol-4-phosphate 5-kinase
 IPR027483  Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
 IPR027484  Phosphatidylinositol-4-phosphate 5-kinase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010506 regulation of autophagy IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0046488 phosphatidylinositol metabolic process IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:2000786 positive regulation of autophagosome assembly IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016307 phosphatidylinositol phosphate kinase activity IEA
 molecular_functionGO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
PI5P Regulates TP53 Acetylation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Synthesis of PIPs in the nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0001858 intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0001870 salivary gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0002499 chronic inflammation "persistent inflammatory response, often caused by persistent infection or during an autoimmune response" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0008593 increased circulating interleukin-10 level "increase in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0008599 increased circulating interleukin-2 level "increase in the amount in the blood of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0008602 increased circulating interleukin-4 level "increase in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0008617 increased circulating interleukin-12 level "increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0008647 increased circulating interleukin-12b level "increase in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0010209 abnormal circulating chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation" [MESH:D12.644.276.374.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

 MP:0013763 increased T-helper cell number "increase in the number of an effector T cell that provides help in the form of secreted cytokines to other immune cells" [CL:0000912]
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Allelic Composition: Slc6a19bucp-2J/Slc6a19bucp-2J
Genetic Background: FVB/NJ-Slc6a19bucp-2J/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018547 Q80XI4 / Pip4k2b / Phosphatidylinositol 5-phosphate 4-kinase type-2 beta / P78356*  / complex
 ENSMUSG00000026737 O70172 / Pip4k2a / Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha / P48426*  / complex
 ENSMUSG00000025417 Q91XU3 / Pip4k2c / Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma / Q8TBX8*  / complex






 

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