ENSMUSG00000028126


Mus musculus

Features
Gene ID: ENSMUSG00000028126
  
Biological name :Pip5k1a
  
Synonyms : P70182 / Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha / Pip5k1a
  
Possible biological names infered from orthology : Q99755
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F2.1
Gene start: 95058530
Gene end: 95106930
  
Corresponding Affymetrix probe sets: 10500069 (MoGene1.0st)   1418144_a_at (Mouse Genome 430 2.0 Array)   1426009_a_at (Mouse Genome 430 2.0 Array)   1435039_a_at (Mouse Genome 430 2.0 Array)   1455191_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102855
Ensembl peptide - ENSMUSP00000005768
Ensembl peptide - ENSMUSP00000102851
Ensembl peptide - ENSMUSP00000102852
NCBI entrez gene - 18720     See in Manteia.
MGI - MGI:107929
RefSeq - NM_008847
RefSeq - XM_017319485
RefSeq - NM_001293707
RefSeq Peptide - NP_001280636
RefSeq Peptide - NP_032873
swissprot - D3YUY3
swissprot - P70182
swissprot - F8WI18
Ensembl - ENSMUSG00000028126
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pip5k1aaENSDARG00000100396Danio rerio
 pip5k1abENSDARG00000024642Danio rerio
 PIP5K1AENSGALG00000027372Gallus gallus
 Q99755ENSG00000143398Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O70161 / Pip5k1c / Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma / O60331*ENSMUSG0000003490266
P70181 / Pip5k1b / Phosphatidylinositol 4-phosphate 5-kinase type-1 beta / O14986*ENSMUSG0000002486757
Q91XU3 / Pip4k2c / Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma / Q8TBX8*ENSMUSG0000002541724
Q80XI4 / Pip4k2b / Phosphatidylinositol 5-phosphate 4-kinase type-2 beta / P78356*ENSMUSG0000001854724
O70172 / Pip4k2a / Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha / P48426*ENSMUSG0000002673722
Q6U7H8 / Pip5kl1 / Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 / Q5T9C9* / phosphatidylinositol-4-phosphate 5-kinase like 1*ENSMUSG0000004685417


Protein motifs (from Interpro)
Interpro ID Name
 IPR002498  Phosphatidylinositol-4-phosphate 5-kinase, core
 IPR023610  Phosphatidylinositol-4-phosphate 5-kinase
 IPR027483  Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
 IPR027484  Phosphatidylinositol-4-phosphate 5-kinase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006661 phosphatidylinositol biosynthetic process IGI
 biological_processGO:0008654 phospholipid biosynthetic process IEA
 biological_processGO:0010761 fibroblast migration IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031532 actin cytoskeleton reorganization IEA
 biological_processGO:0046488 phosphatidylinositol metabolic process IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048041 focal adhesion assembly IEA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0090630 activation of GTPase activity IEA
 biological_processGO:0097178 ruffle assembly IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005847 mRNA cleavage and polyadenylation specificity factor complex IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016307 phosphatidylinositol phosphate kinase activity IEA
 molecular_functionGO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019900 kinase binding IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rab38em1Rkuhn/Rab38em1Rkuhn
Genetic Background: involves: C57BL/6JCrl * FVB/NCrl

Allelic Composition: Pip5k1atm1.1Tba/Pip5k1atm1.1Tba,Pip5k1btm1Tssk/Pip5k1btm1Tssk
Genetic Background: involves: 129P2/OlaHsd

 MP:0001919 abnormal reproductive system physiology "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rab38em1Rkuhn/Rab38em1Rkuhn
Genetic Background: involves: C57BL/6JCrl * FVB/NCrl

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Rab38em1Rkuhn/Rab38em1Rkuhn
Genetic Background: involves: C57BL/6JCrl * FVB/NCrl

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Rab38em1Rkuhn/Rab38em1Rkuhn
Genetic Background: involves: C57BL/6JCrl * FVB/NCrl

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rab38em1Rkuhn/Rab38em1Rkuhn
Genetic Background: involves: C57BL/6JCrl * FVB/NCrl

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dgat2tm1Lex/Dgat2tm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rab38em1Rkuhn/Rab38em1Rkuhn
Genetic Background: involves: C57BL/6JCrl * FVB/NCrl

Allelic Composition: Pip5k1atm1.1Tba/Pip5k1atm1.1Tba,Pip5k1btm1Tssk/Pip5k1btm1Tssk
Genetic Background: involves: 129P2/OlaHsd

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Rab38em1Rkuhn/Rab38em1Rkuhn
Genetic Background: involves: C57BL/6JCrl * FVB/NCrl

 MP:0004182 abnormal spermiation "failure of mature spermatozoa to release from supporting Sertoli cells into the lumen of seminiferous tubules" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pip5k1atm1.1Tba/Pip5k1atm1.1Tba,Pip5k1btm1Tssk/Pip5k1btm1Tssk
Genetic Background: involves: 129P2/OlaHsd

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pip5k1atm1.1Tba/Pip5k1atm1.1Tba,Pip5k1btm1Tssk/Pip5k1btm1Tssk
Genetic Background: involves: 129P2/OlaHsd

 MP:0008893 detached sperm flagellum "fragmentation of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility from the sperm head" [MESH:A05.360.490.890.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pip5k1atm1.1Tba/Pip5k1atm1.1Tba,Pip5k1btm1Tssk/Pip5k1btm1Tssk
Genetic Background: involves: 129P2/OlaHsd

 MP:0009238 coiled sperm flagellum "abnormal twisting of the sperm flagellum into coils or spirals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pip5k1atm1.1Tba/Pip5k1atm1.1Tba,Pip5k1btm1Tssk/Pip5k1btm1Tssk
Genetic Background: involves: 129P2/OlaHsd

 MP:0009647 decreased fertilization frequency "he number of secondary oocytes each penetrated by a spermatozoon followed by fusion of the male and female pronuclei are fewer than expected" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rab38em1Rkuhn/Rab38em1Rkuhn
Genetic Background: involves: C57BL/6JCrl * FVB/NCrl

Allelic Composition: Pip5k1atm1.1Tba/Pip5k1atm1.1Tba,Pip5k1btm1Tssk/Pip5k1btm1Tssk
Genetic Background: involves: 129P2/OlaHsd

 MP:0009831 abnormal sperm midpiece morphology "any structural abnormality of the highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece" [PMID:14581499]
Show

Allelic Composition: Rab38em1Rkuhn/Rab38em1Rkuhn
Genetic Background: involves: C57BL/6JCrl * FVB/NCrl

Allelic Composition: Pip5k1atm1.1Tba/Pip5k1atm1.1Tba,Pip5k1btm1Tssk/Pip5k1btm1Tssk
Genetic Background: involves: 129P2/OlaHsd

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rab38em1Rkuhn/Rab38em1Rkuhn
Genetic Background: involves: C57BL/6JCrl * FVB/NCrl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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