ENSMUSG00000024867


Mus musculus

Features
Gene ID: ENSMUSG00000024867
  
Biological name :Pip5k1b
  
Synonyms : P70181 / Phosphatidylinositol 4-phosphate 5-kinase type-1 beta / Pip5k1b
  
Possible biological names infered from orthology : O14986
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: B
Gene start: 24294794
Gene end: 24555872
  
Corresponding Affymetrix probe sets: 10466779 (MoGene1.0st)   1421833_at (Mouse Genome 430 2.0 Array)   1421834_at (Mouse Genome 430 2.0 Array)   1450389_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025800
Ensembl peptide - ENSMUSP00000108292
NCBI entrez gene - 18719     See in Manteia.
MGI - MGI:107930
RefSeq - XM_006526763
RefSeq - NM_008846
RefSeq Peptide - NP_032872
swissprot - P70181
Ensembl - ENSMUSG00000024867
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pip5k1baENSDARG00000044295Danio rerio
 pip5k1bbENSDARG00000006508Danio rerio
 si:dkey-3h23.3ENSDARG00000104849Danio rerio
 PIP5K1BENSGALG00000015107Gallus gallus
 O14986ENSG00000107242Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O70161 / Pip5k1c / Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma / O60331*ENSMUSG0000003490263
P70182 / Pip5k1a / Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha / Q99755*ENSMUSG0000002812658
Q80XI4 / Pip4k2b / Phosphatidylinositol 5-phosphate 4-kinase type-2 beta / P78356*ENSMUSG0000001854724
Q91XU3 / Pip4k2c / Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma / Q8TBX8*ENSMUSG0000002541722
O70172 / Pip4k2a / Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha / P48426*ENSMUSG0000002673722
Q6U7H8 / Pip5kl1 / Phosphatidylinositol 4-phosphate 5-kinase-like protein 1 / Q5T9C9* / phosphatidylinositol-4-phosphate 5-kinase like 1*ENSMUSG0000004685417


Protein motifs (from Interpro)
Interpro ID Name
 IPR002498  Phosphatidylinositol-4-phosphate 5-kinase, core
 IPR023610  Phosphatidylinositol-4-phosphate 5-kinase
 IPR027483  Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
 IPR027484  Phosphatidylinositol-4-phosphate 5-kinase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006661 phosphatidylinositol biosynthetic process IGI
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0046488 phosphatidylinositol metabolic process IDA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 cellular_componentGO:0001931 uropod ISO
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016307 phosphatidylinositol phosphate kinase activity IEA
 molecular_functionGO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity IGI
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
WNT mediated activation of DVL
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Trp63tm2Brd/Trp63+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Pip5k1atm1.1Tba/Pip5k1atm1.1Tba,Pip5k1btm1Tssk/Pip5k1btm1Tssk
Genetic Background: involves: 129P2/OlaHsd

 MP:0001919 abnormal reproductive system physiology "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rab38em1Rkuhn/Rab38em1Rkuhn
Genetic Background: involves: C57BL/6JCrl * FVB/NCrl

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Trp63tm2Brd/Trp63+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Rab38em1Rkuhn/Rab38em1Rkuhn
Genetic Background: involves: C57BL/6JCrl * FVB/NCrl

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rab38em1Rkuhn/Rab38em1Rkuhn
Genetic Background: involves: C57BL/6JCrl * FVB/NCrl

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hist1h1ttm1Drab/Hist1h1ttm1Drab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rab38em1Rkuhn/Rab38em1Rkuhn
Genetic Background: involves: C57BL/6JCrl * FVB/NCrl

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Rab38em1Rkuhn/Rab38em1Rkuhn
Genetic Background: involves: C57BL/6JCrl * FVB/NCrl

 MP:0004182 abnormal spermiation "failure of mature spermatozoa to release from supporting Sertoli cells into the lumen of seminiferous tubules" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Pip5k1atm1.1Tba/Pip5k1atm1.1Tba,Pip5k1btm1Tssk/Pip5k1btm1Tssk
Genetic Background: involves: 129P2/OlaHsd

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pip5k1atm1.1Tba/Pip5k1atm1.1Tba,Pip5k1btm1Tssk/Pip5k1btm1Tssk
Genetic Background: involves: 129P2/OlaHsd

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hist1h1ttm1Drab/Hist1h1ttm1Drab
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008893 detached sperm flagellum "fragmentation of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility from the sperm head" [MESH:A05.360.490.890.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pip5k1atm1.1Tba/Pip5k1atm1.1Tba,Pip5k1btm1Tssk/Pip5k1btm1Tssk
Genetic Background: involves: 129P2/OlaHsd

 MP:0009238 coiled sperm flagellum "abnormal twisting of the sperm flagellum into coils or spirals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pip5k1atm1.1Tba/Pip5k1atm1.1Tba,Pip5k1btm1Tssk/Pip5k1btm1Tssk
Genetic Background: involves: 129P2/OlaHsd

 MP:0009647 decreased fertilization frequency "he number of secondary oocytes each penetrated by a spermatozoon followed by fusion of the male and female pronuclei are fewer than expected" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp63tm2Brd/Trp63+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Pip5k1atm1.1Tba/Pip5k1atm1.1Tba,Pip5k1btm1Tssk/Pip5k1btm1Tssk
Genetic Background: involves: 129P2/OlaHsd

 MP:0009831 abnormal sperm midpiece morphology "any structural abnormality of the highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece" [PMID:14581499]
Show

Allelic Composition: Pip5k1atm1.1Tba/Pip5k1atm1.1Tba,Pip5k1btm1Tssk/Pip5k1btm1Tssk
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020888 Dvl2 / Q60838 / Segment polarity DVL-2 / O14641* / dishevelled segment polarity protein 2*  / complex / reaction
 ENSMUSG00000029071 Dvl1 / P51141 / Segment polarity DVL-1 / O14640* / dishevelled segment polarity protein 1*  / complex / reaction
 ENSMUSG00000003233 Dvl3 / Q61062 / Segment polarity DVL-3 / Q92997* / dishevelled segment polarity protein 3*  / complex / reaction






 

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