ENSG00000107242


Homo sapiens

Features
Gene ID: ENSG00000107242
  
Biological name :PIP5K1B
  
Synonyms : O14986 / phosphatidylinositol-4-phosphate 5-kinase type 1 beta / PIP5K1B
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q21.11
Gene start: 68705414
Gene end: 69009176
  
Corresponding Affymetrix probe sets: 205632_s_at (Human Genome U133 Plus 2.0 Array)   217477_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000398587
Ensembl peptide - ENSP00000366498
Ensembl peptide - ENSP00000411477
Ensembl peptide - ENSP00000438082
Ensembl peptide - ENSP00000435778
Ensembl peptide - ENSP00000265382
NCBI entrez gene - 8395     See in Manteia.
OMIM - 602745
RefSeq - XM_017015191
RefSeq - XM_011519082
RefSeq - XM_011519083
RefSeq - XM_011519084
RefSeq - XM_017015188
RefSeq - XM_017015189
RefSeq - XM_017015190
RefSeq - NM_001278253
RefSeq - NM_003558
RefSeq - XM_005252261
RefSeq - XM_005252262
RefSeq - XM_006717300
RefSeq - XM_006717301
RefSeq Peptide - NP_001265182
RefSeq Peptide - NP_003549
swissprot - A0A0A0MT25
swissprot - A0A0A0MSP5
swissprot - O14986
swissprot - A0A0A0MRU3
Ensembl - ENSG00000107242
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pip5k1baENSDARG00000044295Danio rerio
 pip5k1bbENSDARG00000006508Danio rerio
 si:dkey-3h23.3ENSDARG00000104849Danio rerio
 PIP5K1BENSGALG00000015107Gallus gallus
 P70181ENSMUSG00000024867Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O60331 / PIP5K1C / phosphatidylinositol-4-phosphate 5-kinase type 1 gammaENSG0000018611163
Q99755 / PIP5K1A / phosphatidylinositol-4-phosphate 5-kinase type 1 alphaENSG0000014339859
P78356 / PIP4K2B / phosphatidylinositol-5-phosphate 4-kinase type 2 betaENSG0000027629324
P48426 / PIP4K2A / phosphatidylinositol-5-phosphate 4-kinase type 2 alphaENSG0000015086722
Q8TBX8 / PIP4K2C / phosphatidylinositol-5-phosphate 4-kinase type 2 gammaENSG0000016690822
Q5T9C9 / PIP5KL1 / phosphatidylinositol-4-phosphate 5-kinase like 1ENSG0000016710316


Protein motifs (from Interpro)
Interpro ID Name
 IPR002498  Phosphatidylinositol-4-phosphate 5-kinase, core
 IPR023610  Phosphatidylinositol-4-phosphate 5-kinase
 IPR027483  Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
 IPR027484  Phosphatidylinositol-4-phosphate 5-kinase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0014066 regulation of phosphatidylinositol 3-kinase signaling TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0046488 phosphatidylinositol metabolic process IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 cellular_componentGO:0001931 uropod IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016307 phosphatidylinositol phosphate kinase activity IEA
 molecular_functionGO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0052810 1-phosphatidylinositol-5-kinase activity TAS
 molecular_functionGO:0052811 1-phosphatidylinositol-3-phosphate 4-kinase activity TAS
 molecular_functionGO:0052812 phosphatidylinositol-3,4-bisphosphate 5-kinase activity TAS


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
WNT mediated activation of DVL
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000004975 DVL2 / O14641 / dishevelled segment polarity protein 2  / complex / reaction
 ENSG00000161202 DVL3 / Q92997 / dishevelled segment polarity protein 3  / reaction / complex
 ENSG00000107404 DVL1 / O14640 / dishevelled segment polarity protein 1  / reaction / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr