ENSG00000143398


Homo sapiens

Features
Gene ID: ENSG00000143398
  
Biological name :PIP5K1A
  
Synonyms : phosphatidylinositol-4-phosphate 5-kinase type 1 alpha / PIP5K1A / Q99755
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q21.3
Gene start: 151197949
Gene end: 151249536
  
Corresponding Affymetrix probe sets: 207391_s_at (Human Genome U133 Plus 2.0 Array)   210256_s_at (Human Genome U133 Plus 2.0 Array)   211205_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000386432
Ensembl peptide - ENSP00000357885
Ensembl peptide - ENSP00000392780
Ensembl peptide - ENSP00000416196
Ensembl peptide - ENSP00000415648
Ensembl peptide - ENSP00000414632
Ensembl peptide - ENSP00000401228
Ensembl peptide - ENSP00000271663
Ensembl peptide - ENSP00000357883
NCBI entrez gene - 8394     See in Manteia.
OMIM - 603275
RefSeq - XM_017002441
RefSeq - XM_006711563
RefSeq - XM_006711564
RefSeq - XM_006711567
RefSeq - XM_006711568
RefSeq - XM_011510043
RefSeq - XM_011510045
RefSeq - XM_011510046
RefSeq - XM_011510048
RefSeq - XM_011510049
RefSeq - XM_017002439
RefSeq - XM_017002440
RefSeq - NM_001135636
RefSeq - NM_001135637
RefSeq - NM_001135638
RefSeq - NM_001330689
RefSeq - NM_003557
RefSeq - XM_005245525
RefSeq - XM_005245527
RefSeq - XM_005245528
RefSeq - XM_005245530
RefSeq - XM_005245531
RefSeq - XM_005245532
RefSeq Peptide - NP_001129109
RefSeq Peptide - NP_001129110
RefSeq Peptide - NP_001317618
RefSeq Peptide - NP_003548
RefSeq Peptide - NP_001129108
swissprot - A2A5X0
swissprot - E9PSF8
swissprot - A6PW58
swissprot - A6PW57
swissprot - A6PW56
swissprot - Q99755
Ensembl - ENSG00000143398
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pip5k1aaENSDARG00000100396Danio rerio
 pip5k1abENSDARG00000024642Danio rerio
 PIP5K1AENSGALG00000027372Gallus gallus
 P70182ENSMUSG00000028126Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O60331 / PIP5K1C / phosphatidylinositol-4-phosphate 5-kinase type 1 gammaENSG0000018611164
O14986 / PIP5K1B / phosphatidylinositol-4-phosphate 5-kinase type 1 betaENSG0000010724256
P78356 / PIP4K2B / phosphatidylinositol-5-phosphate 4-kinase type 2 betaENSG0000027629324
Q8TBX8 / PIP4K2C / phosphatidylinositol-5-phosphate 4-kinase type 2 gammaENSG0000016690823
P48426 / PIP4K2A / phosphatidylinositol-5-phosphate 4-kinase type 2 alphaENSG0000015086722
Q5T9C9 / PIP5KL1 / phosphatidylinositol-4-phosphate 5-kinase like 1ENSG0000016710317


Protein motifs (from Interpro)
Interpro ID Name
 IPR002498  Phosphatidylinositol-4-phosphate 5-kinase, core
 IPR023610  Phosphatidylinositol-4-phosphate 5-kinase
 IPR027483  Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
 IPR027484  Phosphatidylinositol-4-phosphate 5-kinase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006650 glycerophospholipid metabolic process TAS
 biological_processGO:0006661 phosphatidylinositol biosynthetic process IEA
 biological_processGO:0006909 phagocytosis TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0008654 phospholipid biosynthetic process IDA
 biological_processGO:0010761 fibroblast migration IEA
 biological_processGO:0014066 regulation of phosphatidylinositol 3-kinase signaling TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration NAS
 biological_processGO:0030216 keratinocyte differentiation TAS
 biological_processGO:0031532 actin cytoskeleton reorganization IMP
 biological_processGO:0046488 phosphatidylinositol metabolic process IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048041 focal adhesion assembly IMP
 biological_processGO:0060326 cell chemotaxis IMP
 biological_processGO:0072659 protein localization to plasma membrane IMP
 biological_processGO:0090630 activation of GTPase activity IMP
 biological_processGO:0097178 ruffle assembly IMP
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005847 mRNA cleavage and polyadenylation specificity factor complex IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016607 nuclear speck TAS
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016307 phosphatidylinositol phosphate kinase activity IEA
 molecular_functionGO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019900 kinase binding IDA
 molecular_functionGO:0052810 1-phosphatidylinositol-5-kinase activity TAS
 molecular_functionGO:0052811 1-phosphatidylinositol-3-phosphate 4-kinase activity TAS
 molecular_functionGO:0052812 phosphatidylinositol-3,4-bisphosphate 5-kinase activity TAS


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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