ENSG00000150867


Homo sapiens

Features
Gene ID: ENSG00000150867
  
Biological name :PIP4K2A
  
Synonyms : P48426 / phosphatidylinositol-5-phosphate 4-kinase type 2 alpha / PIP4K2A
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: p12.2
Gene start: 22534849
Gene end: 22714555
  
Corresponding Affymetrix probe sets: 205570_at (Human Genome U133 Plus 2.0 Array)   212829_at (Human Genome U133 Plus 2.0 Array)   229713_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000326294
Ensembl peptide - ENSP00000365757
Ensembl peptide - ENSP00000442098
Ensembl peptide - ENSP00000473858
NCBI entrez gene - 5305     See in Manteia.
OMIM - 603140
RefSeq - XM_017016332
RefSeq - NM_001330062
RefSeq - NM_005028
RefSeq - XM_006717450
RefSeq - XM_011519496
RefSeq - XM_017016330
RefSeq - XM_017016331
RefSeq Peptide - NP_001316991
RefSeq Peptide - NP_005019
swissprot - H7BXS3
swissprot - P48426
swissprot - S4R320
Ensembl - ENSG00000150867
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pip4k2aaENSDARG00000003776Danio rerio
 pip4k2abENSDARG00000063544Danio rerio
 PIP4K2AENSGALG00000007877Gallus gallus
 O70172ENSMUSG00000026737Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P78356 / PIP4K2B / phosphatidylinositol-5-phosphate 4-kinase type 2 betaENSG0000027629378
Q8TBX8 / PIP4K2C / phosphatidylinositol-5-phosphate 4-kinase type 2 gammaENSG0000016690864
Q99755 / PIP5K1A / phosphatidylinositol-4-phosphate 5-kinase type 1 alphaENSG0000014339831
O14986 / PIP5K1B / phosphatidylinositol-4-phosphate 5-kinase type 1 betaENSG0000010724230
O60331 / PIP5K1C / phosphatidylinositol-4-phosphate 5-kinase type 1 gammaENSG0000018611130
Q5T9C9 / PIP5KL1 / phosphatidylinositol-4-phosphate 5-kinase like 1ENSG0000016710322


Protein motifs (from Interpro)
Interpro ID Name
 IPR002498  Phosphatidylinositol-4-phosphate 5-kinase, core
 IPR023610  Phosphatidylinositol-4-phosphate 5-kinase
 IPR027483  Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
 IPR027484  Phosphatidylinositol-4-phosphate 5-kinase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006644 phospholipid metabolic process TAS
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0010506 regulation of autophagy IMP
 biological_processGO:0014066 regulation of phosphatidylinositol 3-kinase signaling TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035855 megakaryocyte development IEA
 biological_processGO:0046488 phosphatidylinositol metabolic process IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:2000786 positive regulation of autophagosome assembly IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005776 autophagosome IMP
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016307 phosphatidylinositol phosphate kinase activity IEA
 molecular_functionGO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity NAS
 molecular_functionGO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0052811 1-phosphatidylinositol-3-phosphate 4-kinase activity TAS


Pathways (from Reactome)
Pathway description
Synthesis of PIPs at the plasma membrane
PI5P Regulates TP53 Acetylation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Synthesis of PIPs in the nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000127445 PIN1 / Q13526 / peptidylprolyl cis/trans isomerase, NIMA-interacting 1  / complex / reaction
 ENSG00000150867 P48426 / PIP4K2A / phosphatidylinositol-5-phosphate 4-kinase type 2 alpha  / complex
 ENSG00000276293 P78356 / PIP4K2B / phosphatidylinositol-5-phosphate 4-kinase type 2 beta  / complex
 ENSG00000166908 Q8TBX8 / PIP4K2C / phosphatidylinositol-5-phosphate 4-kinase type 2 gamma  / complex
 ENSG00000108984 MAP2K6 / P52564 / mitogen-activated protein kinase kinase 6  / reaction






 

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