ENSG00000127445


Homo sapiens

Features
Gene ID: ENSG00000127445
  
Biological name :PIN1
  
Synonyms : peptidylprolyl cis/trans isomerase, NIMA-interacting 1 / PIN1 / Q13526
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.2
Gene start: 9835257
Gene end: 9849682
  
Corresponding Affymetrix probe sets: 202927_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000466656
Ensembl peptide - ENSP00000466962
Ensembl peptide - ENSP00000467197
Ensembl peptide - ENSP00000247970
Ensembl peptide - ENSP00000466780
NCBI entrez gene - 5300     See in Manteia.
OMIM - 601052
RefSeq - XM_011528068
RefSeq - NM_006221
RefSeq Peptide - NP_006212
swissprot - K7EP26
swissprot - K7EMU7
swissprot - Q13526
swissprot - K7EN45
Ensembl - ENSG00000127445
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pin1ENSDARG00000101915Danio rerio
 Pin1ENSMUSG00000032171Mus musculus
 Pin1rt1ENSMUSG00000074997Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000297  Peptidyl-prolyl cis-trans isomerase, PpiC-type
 IPR001202  WW domain
 IPR023058  Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site
 IPR036020  WW domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000413 protein peptidyl-prolyl isomerization IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IGI
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007088 regulation of mitotic nuclear division TAS
 biological_processGO:0030182 neuron differentiation ISS
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IDA
 biological_processGO:0032091 negative regulation of protein binding IDA
 biological_processGO:0032465 regulation of cytokinesis IMP
 biological_processGO:0032480 negative regulation of type I interferon production TAS
 biological_processGO:0035307 positive regulation of protein dephosphorylation TAS
 biological_processGO:0042177 negative regulation of protein catabolic process IDA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0043547 positive regulation of GTPase activity IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0050808 synapse organization ISS
 biological_processGO:0050821 protein stabilization ISS
 biological_processGO:0051443 positive regulation of ubiquitin-protein transferase activity IDA
 biological_processGO:0060393 regulation of pathway-restricted SMAD protein phosphorylation IDA
 biological_processGO:0061051 positive regulation of cell growth involved in cardiac muscle cell development IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IDA
 biological_processGO:1900180 regulation of protein localization to nucleus IDA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 biological_processGO:2000146 negative regulation of cell motility IDA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0030496 midbody IDA
 cellular_componentGO:0043005 neuron projection IEA
 molecular_functionGO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA
 molecular_functionGO:0003774 motor activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding ISS
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IPI
 molecular_functionGO:0032794 GTPase activating protein binding IPI
 molecular_functionGO:0050815 phosphoserine residue binding IDA
 molecular_functionGO:0050816 phosphothreonine residue binding IPI
 molecular_functionGO:0051219 phosphoprotein binding ISS


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
Regulation of TP53 Activity through Phosphorylation
PI5P Regulates TP53 Acetylation
Negative regulators of DDX58/IFIH1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000276293 P78356 / PIP4K2B / phosphatidylinositol-5-phosphate 4-kinase type 2 beta  / complex / reaction
 ENSG00000164938 Q96A56 / TP53INP1 / tumor protein p53 inducible nuclear protein 1  / reaction / complex
 ENSG00000150867 P48426 / PIP4K2A / phosphatidylinositol-5-phosphate 4-kinase type 2 alpha  / complex / reaction
 ENSG00000126456 IRF3 / Q14653 / interferon regulatory factor 3  / complex / reaction
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / complex / reaction
 ENSG00000064393 HIPK2 / Q9H2X6 / homeodomain interacting protein kinase 2  / complex






 

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