ENSMUSG00000032171


Mus musculus

Features
Gene ID: ENSMUSG00000032171
  
Biological name :Pin1
  
Synonyms : Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 / Pin1 / Q9QUR7
  
Possible biological names infered from orthology : peptidylprolyl cis/trans isomerase, NIMA-interacting 1 / Q13526
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A3
Gene start: 20652095
Gene end: 20666584
  
Corresponding Affymetrix probe sets: 10583472 (MoGene1.0st)   1416228_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034689
NCBI entrez gene - 23988     See in Manteia.
MGI - MGI:1346036
RefSeq - NM_023371
RefSeq Peptide - NP_075860
swissprot - Q9QUR7
Ensembl - ENSMUSG00000032171
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pin1ENSDARG00000101915Danio rerio
 PIN1ENSG00000127445Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pin1rt1 / PIN1* / Q13526* / peptidylprolyl cis/trans isomerase, NIMA-interacting 1*ENSMUSG0000007499790


Protein motifs (from Interpro)
Interpro ID Name
 IPR000297  Peptidyl-prolyl cis-trans isomerase, PpiC-type
 IPR001202  WW domain
 IPR023058  Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site
 IPR036020  WW domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000413 protein peptidyl-prolyl isomerization IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0030182 neuron differentiation IMP
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway ISO
 biological_processGO:0032091 negative regulation of protein binding ISO
 biological_processGO:0032465 regulation of cytokinesis ISO
 biological_processGO:0035307 positive regulation of protein dephosphorylation IEA
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0042177 negative regulation of protein catabolic process ISO
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0043525 positive regulation of neuron apoptotic process IEA
 biological_processGO:0043547 positive regulation of GTPase activity ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0050808 synapse organization IMP
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0051443 positive regulation of ubiquitin-protein transferase activity ISO
 biological_processGO:0060393 regulation of pathway-restricted SMAD protein phosphorylation ISO
 biological_processGO:0061051 positive regulation of cell growth involved in cardiac muscle cell development IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade ISO
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IC
 biological_processGO:1900180 regulation of protein localization to nucleus ISO
 biological_processGO:2000146 negative regulation of cell motility ISO
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0030496 midbody ISO
 cellular_componentGO:0043005 neuron projection IEA
 molecular_functionGO:0003755 peptidyl-prolyl cis-trans isomerase activity ISO
 molecular_functionGO:0003774 motor activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IPI
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding ISO
 molecular_functionGO:0032794 GTPase activating protein binding ISO
 molecular_functionGO:0050815 phosphoserine residue binding ISO
 molecular_functionGO:0050816 phosphothreonine residue binding ISO
 molecular_functionGO:0051219 phosphoprotein binding IPI


Pathways (from Reactome)
Pathway description
Regulation of TP53 Activity through Phosphorylation
PI5P Regulates TP53 Acetylation
Negative regulators of DDX58/IFIH1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0003329 amyloid beta deposits 
Show

Allelic Composition: Mtss1Gt(CSC156)Byg/Mtss1+
Genetic Background: B6.129P2-Mtss1Gt(CSC156)Byg

Allelic Composition: Pin1tm1Tuc/Pin1tm1Tuc,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * SJL

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008390 abnormal primordial germ cell proliferation "anomaly in the ability of the primordial germ cell population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0008392 decreased primordial germ cell number "reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

 MP:0008871 abnormal ovarian follicle number "abnormal numbers of spheroid cell aggregations in the ovary" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Esr1tm1Ksk/Esr1tm1Ksk,Esr2tm1Unc/Esr2tm1Unc
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003184 Irf3 / P70671 / interferon regulatory factor 3 / Q14653*  / reaction / complex
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / reaction / complex
 ENSMUSG00000026737 O70172 / Pip4k2a / Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha / P48426*  / complex / reaction
 ENSMUSG00000018547 Q80XI4 / Pip4k2b / Phosphatidylinositol 5-phosphate 4-kinase type-2 beta / P78356*  / reaction / complex
 ENSMUSG00000028211 Q9QXE4 / Trp53inp1 / transformation related protein 53 inducible nuclear protein 1 / Q96A56* / TP53INP1* / tumor protein p53 inducible nuclear protein 1*  / reaction / complex
 ENSMUSG00000061436 Hipk2 / Q9QZR5 / homeodomain interacting protein kinase 2 / Q9H2X6*  / complex






 

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